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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Elf5
Z-value: 3.54
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Transcription factors associated with Elf5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf5 | mm10_v2_chr2_+_103424820_103424829 | -0.49 | 2.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.3 | GO:0019395 | fatty acid oxidation(GO:0019395) |
| 1.1 | 19.4 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 3.8 | 19.0 | GO:0031438 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.3 | 18.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 4.4 | 17.8 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.8 | 15.1 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.6 | 12.9 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.3 | 12.7 | GO:1901998 | toxin transport(GO:1901998) |
| 0.7 | 12.6 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.1 | 12.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 51.7 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 33.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 28.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 19.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 2.4 | 19.4 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.6 | 19.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.3 | 17.4 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 17.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 15.4 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.5 | 14.3 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 19.0 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 17.3 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 1.6 | 16.1 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.4 | 14.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 2.1 | 12.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.2 | 11.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.9 | 10.9 | GO:0031543 | peptidyl-proline dioxygenase activity(GO:0031543) |
| 0.3 | 10.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.9 | 10.3 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 9.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 11.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 11.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.4 | 10.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 8.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.3 | 7.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 7.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 7.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 6.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 15.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 14.6 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.2 | 13.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 13.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 12.6 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.2 | 10.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.5 | 7.7 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.2 | 7.6 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.5 | 7.3 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |