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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Ddit3
Z-value: 0.91
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Transcription factors associated with Ddit3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ddit3 | mm10_v2_chr10_+_127290774_127290803 | -0.75 | 1.2e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_105131800 Show fit | 4.91 |
ENSMUST00000161289.1
|
carboxylesterase 4A |
|
| chr9_-_48605147 Show fit | 4.77 |
ENSMUST00000034808.5
ENSMUST00000119426.1 |
nicotinamide N-methyltransferase |
|
| chr2_+_119351222 Show fit | 2.95 |
ENSMUST00000028780.3
|
ChaC, cation transport regulator 1 |
|
| chr14_+_65971164 Show fit | 1.86 |
ENSMUST00000144619.1
|
clusterin |
|
| chr9_-_70141484 Show fit | 1.85 |
ENSMUST00000034749.8
|
family with sequence similarity 81, member A |
|
| chr19_-_59076069 Show fit | 1.63 |
ENSMUST00000047511.7
ENSMUST00000163821.1 |
RIKEN cDNA 4930506M07 gene |
|
| chr14_-_66868572 Show fit | 1.58 |
ENSMUST00000022629.8
|
dihydropyrimidinase-like 2 |
|
| chr14_+_65970804 Show fit | 1.58 |
ENSMUST00000138191.1
|
clusterin |
|
| chr8_+_45627709 Show fit | 1.53 |
ENSMUST00000134321.1
ENSMUST00000135336.1 |
sorbin and SH3 domain containing 2 |
|
| chr8_+_45627946 Show fit | 1.49 |
ENSMUST00000145458.1
|
sorbin and SH3 domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ddit3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.9 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.2 | 2.9 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.9 | 2.7 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.0 | 2.7 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 2.1 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.1 | 1.8 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 1.7 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.0 | 1.7 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.5 | 1.4 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.5 | 1.4 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.9 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 3.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 1.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 1.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 1.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.2 | 1.2 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.3 | 1.0 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.2 | 4.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.6 | 2.9 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.5 | 2.7 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.0 | 2.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 2.0 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.1 | 1.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 1.6 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.5 | 1.4 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.2 | 1.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 2.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.7 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.7 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 5.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 3.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.8 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.4 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 1.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 1.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |