ISMARA results: Crem

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Crem_Jdp2

Z-value: 1.01

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Transcription factors associated with Crem_Jdp2

Gene Symbol	Gene ID	Gene Info
Crem Ensembl NCBI MGI UniProt	ENSMUSG00000063889.10	cAMP responsive element modulator
Jdp2 Ensembl NCBI MGI UniProt	ENSMUSG00000034271.9	Jun dimerization protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Crem	mm10_v2_chr18_-_3281036_3281132	0.67	7.4e-06	Click!
Jdp2	mm10_v2_chr12_+_85599047_85599105	-0.23	1.8e-01	Click!

Activity profile of Crem_Jdp2 motif

Sorted Z-values of Crem_Jdp2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_155276297 Show fit	4.83	ENSMUST00000029128.3	Map1lc3a Ensembl NCBI MGI UniProt Show fit	microtubule-associated protein 1 light chain 3 alpha
chr18_-_3281036 Show fit	3.60	ENSMUST00000049942.6 ENSMUST00000139537.1 ENSMUST00000124747.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr18_-_3281712 Show fit	2.81	ENSMUST00000182204.1 ENSMUST00000154705.1 ENSMUST00000182833.1 ENSMUST00000151084.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr3_-_20275659 Show fit	2.79	ENSMUST00000011607.5	Cpb1 Ensembl NCBI MGI UniProt Show fit	carboxypeptidase B1 (tissue)
chr1_+_71652837 Show fit	2.76	ENSMUST00000097699.2	Apol7d Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 7d
chr2_+_143546144 Show fit	2.70	ENSMUST00000028905.9	Pcsk2 Ensembl NCBI MGI UniProt Show fit	proprotein convertase subtilisin/kexin type 2
chr1_-_79440039 Show fit	2.62	ENSMUST00000049972.4	Scg2 Ensembl NCBI MGI UniProt Show fit	secretogranin II
chr18_-_3281752 Show fit	2.61	ENSMUST00000140332.1 ENSMUST00000147138.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr4_+_141301228 Show fit	2.04	ENSMUST00000006614.2	Epha2 Ensembl NCBI MGI UniProt Show fit	Eph receptor A2
chr16_-_23890805 Show fit	1.97	ENSMUST00000004480.3	Sst Ensembl NCBI MGI UniProt Show fit	somatostatin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Crem_Jdp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.8	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.6	6.2	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1	4.8	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.2	2.9	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
0.2	2.9	GO:0014883	transition between fast and slow fiber(GO:0014883)
0.7	2.7	GO:0030070	insulin processing(GO:0030070)
0.2	2.6	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.5	2.5	GO:1904720	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3	2.2	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.7	2.1	GO:0035973	aggrephagy(GO:0035973)

Showing 1 to 10 of 181 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.4	GO:0005667	transcription factor complex(GO:0005667)
0.3	4.8	GO:0044754	autolysosome(GO:0044754)
0.8	3.9	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.1	2.9	GO:0055038	recycling endosome membrane(GO:0055038)
0.7	2.8	GO:0071148	TEAD-1-YAP complex(GO:0071148)
0.0	2.2	GO:0030027	lamellipodium(GO:0030027)
0.1	2.1	GO:0072546	ER membrane protein complex(GO:0072546)
0.0	2.0	GO:0016460	myosin II complex(GO:0016460)
0.0	1.9	GO:0005776	autophagosome(GO:0005776)
0.6	1.8	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)

Showing 1 to 10 of 73 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.6	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)
0.5	5.4	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.1	3.3	GO:0070412	R-SMAD binding(GO:0070412)
0.1	3.2	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	3.0	GO:0031489	myosin V binding(GO:0031489)
0.5	2.9	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2	2.8	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.1	2.8	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.1	2.6	GO:0042056	chemoattractant activity(GO:0042056)
0.1	2.5	GO:0008327	methyl-CpG binding(GO:0008327)

Showing 1 to 10 of 114 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	13.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	3.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	2.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	2.2	PID LKB1 PATHWAY	LKB1 signaling events
0.1	2.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	1.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.4	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	2.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	2.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	2.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	2.0	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	2.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.9	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	1.8	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	1.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1	1.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling

Showing 1 to 10 of 48 entries

Results for Crem_Jdp2

Z-value: 1.01

Motif logo

Transcription factors associated with Crem_Jdp2

Activity-expression correlation:

Activity profile of Crem_Jdp2 motif

Sorted Z-values of Crem_Jdp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Crem_Jdp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: