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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for GUAACAG
Z-value: 0.53
Motif logo
miRNA associated with seed GUAACAG
| Name | miRBASE accession |
|---|---|
|
mmu-miR-194-5p
|
MIMAT0000224 |
Activity profile of GUAACAG motif
Sorted Z-values of GUAACAG motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GUAACAG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.2 | 0.5 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 0.2 | 0.2 | GO:0019072 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.2 | 0.6 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.1 | 0.5 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.1 | 0.4 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) |
| 0.1 | 0.5 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 0.3 | GO:0060061 | Spemann organizer formation(GO:0060061) |
| 0.1 | 0.4 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) |
| 0.1 | 0.3 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 0.3 | GO:0021649 | vestibulocochlear nerve structural organization(GO:0021649) cell migration involved in vasculogenesis(GO:0035441) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) |
| 0.1 | 0.3 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 0.2 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.1 | 0.2 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
| 0.1 | 0.2 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.1 | 0.2 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 0.2 | GO:0051977 | lysophospholipid transport(GO:0051977) |
| 0.1 | 0.2 | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.1 | 0.2 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.1 | 0.3 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 0.4 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.1 | 0.3 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.0 | 0.1 | GO:0002946 | tRNA C5-cytosine methylation(GO:0002946) |
| 0.0 | 0.1 | GO:0009826 | unidimensional cell growth(GO:0009826) |
| 0.0 | 0.1 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.0 | 0.1 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.0 | 0.2 | GO:0021553 | olfactory nerve development(GO:0021553) |
| 0.0 | 0.3 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.4 | GO:0072393 | microtubule anchoring at microtubule organizing center(GO:0072393) |
| 0.0 | 0.6 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.4 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.0 | 0.1 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.0 | 0.3 | GO:2000232 | regulation of rRNA processing(GO:2000232) |
| 0.0 | 0.2 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.0 | 0.3 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.0 | 0.4 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 0.1 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.0 | 0.3 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.0 | 0.2 | GO:0001923 | B-1 B cell differentiation(GO:0001923) |
| 0.0 | 0.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.0 | 0.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.2 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.0 | 0.1 | GO:1900045 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.0 | 0.1 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.0 | 0.2 | GO:0015871 | choline transport(GO:0015871) |
| 0.0 | 0.1 | GO:0051030 | snRNA transport(GO:0051030) |
| 0.0 | 0.2 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.0 | 0.3 | GO:0033129 | positive regulation of histone phosphorylation(GO:0033129) |
| 0.0 | 0.4 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.2 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.0 | 0.1 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.0 | 0.2 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.0 | 0.1 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.0 | 0.1 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 0.0 | 0.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.4 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.1 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.0 | 0.2 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.0 | 0.1 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.0 | 0.1 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.0 | 0.3 | GO:0042119 | neutrophil activation(GO:0042119) |
| 0.0 | 0.4 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.0 | 0.1 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.0 | 0.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.0 | 0.1 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.0 | 0.2 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.0 | 0.0 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.0 | 0.4 | GO:2000352 | negative regulation of endothelial cell apoptotic process(GO:2000352) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.1 | 0.5 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.6 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.3 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.1 | 0.3 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.0 | 0.3 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.0 | 0.3 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.3 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 0.4 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 0.1 | GO:1902737 | viral replication complex(GO:0019034) dendritic filopodium(GO:1902737) |
| 0.0 | 0.1 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.0 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.2 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.0 | 0.2 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.2 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.2 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.0 | 0.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.2 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.1 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.6 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.2 | GO:0000145 | exocyst(GO:0000145) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 0.4 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.1 | 0.2 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.1 | 0.3 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.1 | 0.3 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.1 | 0.2 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.1 | 0.2 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.0 | 0.3 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 0.2 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.0 | 0.2 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.0 | 0.2 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.0 | 1.6 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 0.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 0.4 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.2 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.1 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.0 | 0.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.2 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.2 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.0 | 0.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.1 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.0 | 0.2 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.4 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |