ISMARA results: Yy1

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GSE58827: Dynamics of the Mouse Liver

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Results for Yy1_Yy2

Z-value: 2.91

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Transcription factors associated with Yy1_Yy2

Gene Symbol	Gene ID	Gene Info
Yy1 Ensembl NCBI MGI UniProt	ENSMUSG00000021264.11	YY1 transcription factor
Yy2 Ensembl NCBI MGI UniProt	ENSMUSG00000091736.2	Yy2 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Yy2	mm10_v2_chrX_-_157598642_157598655	-0.41	1.2e-02	Click!
Yy1	mm10_v2_chr12_+_108792946_108792988	-0.26	1.3e-01	Click!

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_69284982 Show fit	9.10	ENSMUST00000183882.1 ENSMUST00000037064.4	Slc25a37 Ensembl NCBI MGI UniProt Show fit	solute carrier family 25, member 37
chr5_-_134915512 Show fit	8.03	ENSMUST00000008987.4	Cldn13 Ensembl NCBI MGI UniProt Show fit	claudin 13
chr13_-_21753851 Show fit	7.22	ENSMUST00000074752.2	Hist1h2ak Ensembl NCBI MGI UniProt Show fit	histone cluster 1, H2ak
chr13_-_23551648 Show fit	6.74	ENSMUST00000102971.1	Hist1h4f Ensembl NCBI MGI UniProt Show fit	histone cluster 1, H4f
chr8_-_121907678 Show fit	6.42	ENSMUST00000045557.9	Slc7a5 Ensembl NCBI MGI UniProt Show fit	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr4_-_46404224 Show fit	5.97	ENSMUST00000107764.2	Hemgn Ensembl NCBI MGI UniProt Show fit	hemogen
chr11_+_117849286 Show fit	5.55	ENSMUST00000093906.4	Birc5 Ensembl NCBI MGI UniProt Show fit	baculoviral IAP repeat-containing 5
chr15_-_103252810 Show fit	5.52	ENSMUST00000154510.1	Nfe2 Ensembl NCBI MGI UniProt Show fit	nuclear factor, erythroid derived 2
chr10_+_43579161 Show fit	5.51	ENSMUST00000058714.8	Cd24a Ensembl NCBI MGI UniProt Show fit	CD24a antigen
chr7_-_103843154 Show fit	5.49	ENSMUST00000063957.4	Hbb-bh1 Ensembl NCBI MGI UniProt Show fit	hemoglobin Z, beta-like embryonic chain

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	46.1	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5	32.9	GO:0002181	cytoplasmic translation(GO:0002181)
0.2	23.0	GO:0045814	negative regulation of gene expression, epigenetic(GO:0045814)
0.8	19.4	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.1	17.6	GO:0016072	rRNA metabolic process(GO:0016072)
0.4	14.6	GO:0000027	ribosomal large subunit assembly(GO:0000027)
2.2	13.4	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.2	12.0	GO:0070527	platelet aggregation(GO:0070527)
0.8	11.9	GO:0015816	glycine transport(GO:0015816)
0.9	11.3	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)

Showing 1 to 10 of 905 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	75.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.9	45.8	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.2	45.4	GO:0000788	nuclear nucleosome(GO:0000788)
0.6	27.6	GO:0000786	nucleosome(GO:0000786)
2.7	21.8	GO:0005833	hemoglobin complex(GO:0005833)
0.2	15.9	GO:0032993	protein-DNA complex(GO:0032993)
0.2	13.6	GO:0044391	ribosomal subunit(GO:0044391)
2.3	13.5	GO:0032133	chromosome passenger complex(GO:0032133)
0.4	10.0	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	9.9	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)

Showing 1 to 10 of 363 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	117.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.6	32.4	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	20.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.4	17.8	GO:0050699	WW domain binding(GO:0050699)
3.4	13.4	GO:0031721	hemoglobin alpha binding(GO:0031721)
0.3	11.9	GO:0008536	Ran GTPase binding(GO:0008536)
1.5	11.8	GO:0050786	RAGE receptor binding(GO:0050786)
0.8	11.7	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.1	11.6	GO:0004519	endonuclease activity(GO:0004519)
1.9	11.4	GO:0004852	uroporphyrinogen-III synthase activity(GO:0004852)

Showing 1 to 10 of 546 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	26.6	PID AURORA A PATHWAY	Aurora A signaling
0.3	20.1	PID PLK1 PATHWAY	PLK1 signaling events
0.2	18.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.4	14.5	PID ATR PATHWAY	ATR signaling pathway
0.2	13.9	PID P53 REGULATION PATHWAY	p53 pathway
0.2	10.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	9.7	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	9.0	PID ARF6 PATHWAY	Arf6 signaling events
0.2	8.4	PID AURORA B PATHWAY	Aurora B signaling
0.1	7.6	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	126.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.2	64.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	21.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.4	20.8	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.5	16.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.6	14.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.2	13.6	REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.3	12.4	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.6	11.6	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2	10.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling

Showing 1 to 10 of 172 entries

Results for Yy1_Yy2

Z-value: 2.91

Motif logo

Transcription factors associated with Yy1_Yy2

Activity-expression correlation:

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: