Project
GSE58827: Dynamics of the Mouse Liver
Navigation
Downloads
Results for Tfdp1_Wt1_Egr2
Z-value: 3.03
Motif logo
Transcription factors associated with Tfdp1_Wt1_Egr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfdp1 | mm10_v2_chr8_+_13339656_13339674 | 0.89 | 5.3e-13 | Click! |
| Wt1 | mm10_v2_chr2_+_105126505_105126529 | 0.76 | 9.7e-08 | Click! |
| Egr2 | mm10_v2_chr10_+_67535493_67535583 | 0.56 | 3.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfdp1_Wt1_Egr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 98.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 10.2 | 81.9 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 1.2 | 54.8 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 4.7 | 51.5 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
| 1.1 | 44.8 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
| 10.0 | 40.1 | GO:1904799 | regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) |
| 2.7 | 35.6 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.9 | 35.6 | GO:0006284 | base-excision repair(GO:0006284) |
| 4.1 | 32.9 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 1.2 | 32.0 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 93.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.7 | 64.8 | GO:0005814 | centriole(GO:0005814) |
| 0.5 | 56.5 | GO:0000776 | kinetochore(GO:0000776) |
| 1.0 | 55.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.6 | 55.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 1.0 | 53.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.7 | 53.7 | GO:0005844 | polysome(GO:0005844) |
| 0.5 | 38.4 | GO:0016605 | PML body(GO:0016605) |
| 0.4 | 35.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 1.6 | 33.9 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 154.2 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.4 | 90.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.8 | 79.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.9 | 69.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.5 | 51.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 49.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.8 | 46.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.7 | 46.3 | GO:0019209 | kinase activator activity(GO:0019209) |
| 0.3 | 46.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.3 | 36.5 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 95.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 4.2 | 66.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.2 | 60.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.7 | 60.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 54.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 1.3 | 54.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.1 | 50.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 1.2 | 49.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 1.3 | 47.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.0 | 45.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 103.5 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 3.2 | 67.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.9 | 63.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.4 | 60.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 2.9 | 59.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.6 | 52.2 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 1.3 | 51.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.9 | 41.7 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 1.5 | 40.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 40.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |