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GSE58827: Dynamics of the Mouse Liver
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Results for Tcf4_Mesp1
Z-value: 1.08
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Transcription factors associated with Tcf4_Mesp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf4 | mm10_v2_chr18_+_69346143_69346203 | 0.36 | 3.0e-02 | Click! |
| Mesp1 | mm10_v2_chr7_-_79793788_79793788 | 0.34 | 4.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_20269162 Show fit | 9.98 |
ENSMUST00000024155.7
|
potassium channel, subfamily K, member 16 |
|
| chr2_-_28563362 Show fit | 7.31 |
ENSMUST00000028161.5
|
carboxyl ester lipase |
|
| chr17_-_26201328 Show fit | 7.24 |
ENSMUST00000025019.2
|
Rho GDP dissociation inhibitor (GDI) gamma |
|
| chr6_+_41458923 Show fit | 6.65 |
ENSMUST00000031910.7
|
protease, serine, 1 (trypsin 1) |
|
| chr14_-_70635946 Show fit | 6.55 |
ENSMUST00000022695.9
|
dematin actin binding protein |
|
| chr6_+_41392356 Show fit | 5.84 |
ENSMUST00000049079.7
|
predicted gene 5771 |
|
| chr12_-_76709997 Show fit | 5.55 |
ENSMUST00000166101.1
|
spectrin beta, erythrocytic |
|
| chr3_-_20275659 Show fit | 5.47 |
ENSMUST00000011607.5
|
carboxypeptidase B1 (tissue) |
|
| chr17_-_26201363 Show fit | 5.03 |
ENSMUST00000121959.1
|
Rho GDP dissociation inhibitor (GDI) gamma |
|
| chrX_-_73659724 Show fit | 4.86 |
ENSMUST00000114473.1
ENSMUST00000002087.7 |
pregnancy upregulated non-ubiquitously expressed CaM kinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tcf4_Mesp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 12.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 11.7 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.1 | 11.1 | GO:0007586 | digestion(GO:0007586) |
| 0.3 | 7.7 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.4 | 7.5 | GO:0046514 | ceramide catabolic process(GO:0046514) |
| 0.5 | 7.0 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 2.2 | 6.6 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.9 | 6.6 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
| 0.1 | 6.0 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.7 | 5.9 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 9.2 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 7.2 | GO:0005844 | polysome(GO:0005844) |
| 1.6 | 6.6 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.4 | 6.1 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.2 | 6.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.8 | 5.6 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 5.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 4.7 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 4.6 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.7 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 1.5 | 12.3 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.8 | 12.0 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 9.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 9.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.3 | 8.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 8.3 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.2 | 7.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 2.6 | 7.7 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
| 0.2 | 6.5 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 16.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 7.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 3.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 3.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 3.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 3.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 11.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.9 | 10.5 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 5.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 5.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 5.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 4.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 4.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 4.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 4.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |