ISMARA results: Tbx5

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GSE58827: Dynamics of the Mouse Liver

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Results for Tbx5

Z-value: 1.37

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Transcription factors associated with Tbx5

Gene Symbol	Gene ID	Gene Info
Tbx5 Ensembl NCBI MGI UniProt	ENSMUSG00000018263.8	T-box 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbx5	mm10_v2_chr5_+_119834663_119834663	0.28	9.8e-02	Click!

Activity profile of Tbx5 motif

Sorted Z-values of Tbx5 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_80000292 Show fit	10.98	ENSMUST00000088735.3	Olfm4 Ensembl NCBI MGI UniProt Show fit	olfactomedin 4
chr10_+_75566257 Show fit	10.95	ENSMUST00000129232.1 ENSMUST00000143792.1	Ggt1 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 1
chr8_+_23035116 Show fit	9.84	ENSMUST00000117296.1 ENSMUST00000141784.2	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr4_-_134018829 Show fit	9.18	ENSMUST00000051674.2	Lin28a Ensembl NCBI MGI UniProt Show fit	lin-28 homolog A (C. elegans)
chr11_-_87875524 Show fit	8.30	ENSMUST00000049768.3	Epx Ensembl NCBI MGI UniProt Show fit	eosinophil peroxidase
chr7_-_142666816 Show fit	8.04	ENSMUST00000105935.1	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr15_-_89425856 Show fit	7.81	ENSMUST00000109313.2	Cpt1b Ensembl NCBI MGI UniProt Show fit	carnitine palmitoyltransferase 1b, muscle
chr15_-_103255433 Show fit	7.69	ENSMUST00000075192.6	Nfe2 Ensembl NCBI MGI UniProt Show fit	nuclear factor, erythroid derived 2
chr1_-_132390301 Show fit	6.98	ENSMUST00000132435.1	Tmcc2 Ensembl NCBI MGI UniProt Show fit	transmembrane and coiled-coil domains 2
chr3_-_20275659 Show fit	6.92	ENSMUST00000011607.5	Cpb1 Ensembl NCBI MGI UniProt Show fit	carboxypeptidase B1 (tissue)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	13.2	GO:0015909	long-chain fatty acid transport(GO:0015909)
0.3	11.1	GO:0048821	erythrocyte development(GO:0048821)
0.2	11.0	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.4	10.9	GO:1901748	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.1	10.1	GO:0010587	miRNA catabolic process(GO:0010587)
0.4	9.9	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.9	9.5	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.6	9.2	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.7	8.4	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
2.8	8.3	GO:0002215	defense response to nematode(GO:0002215)

Showing 1 to 10 of 146 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	20.4	GO:0005615	extracellular space(GO:0005615)
0.9	12.4	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.7	11.0	GO:0042581	specific granule(GO:0042581)
0.1	11.0	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.4	9.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	9.8	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.2	9.7	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3	8.0	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	7.4	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.7	7.2	GO:0033093	Weibel-Palade body(GO:0033093)

Showing 1 to 10 of 79 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	16.8	GO:0070888	E-box binding(GO:0070888)
0.4	13.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
2.6	12.9	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.9	10.9	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	9.9	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
1.0	9.8	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.8	9.5	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.2	8.6	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.1	8.4	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
1.6	8.0	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)

Showing 1 to 10 of 119 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	8.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	6.2	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	4.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	4.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	3.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	3.9	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	3.8	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	3.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	3.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.9	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.4	10.8	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2	9.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.2	9.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	8.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	8.0	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	7.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	6.2	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.1	3.9	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.1	3.8	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Showing 1 to 10 of 44 entries

Results for Tbx5

Z-value: 1.37

Motif logo

Transcription factors associated with Tbx5

Activity-expression correlation:

Activity profile of Tbx5 motif

Sorted Z-values of Tbx5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: