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GSE58827: Dynamics of the Mouse Liver

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Results for Tbx2

Z-value: 1.35

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Transcription factors associated with Tbx2

Gene Symbol Gene ID Gene Info
Tbx2
ENSMUSG00000000093.6 T-box 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.633.9e-05Click!

Activity profile of Tbx2 motif

Sorted Z-values of Tbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_130826676 18.75 ENSMUST00000027675.7
Pigr
polymeric immunoglobulin receptor
chr1_+_130826762 17.86 ENSMUST00000133792.1
Pigr
polymeric immunoglobulin receptor
chr6_-_141856171 13.53 ENSMUST00000165990.1
ENSMUST00000163678.1
Slco1a4
solute carrier organic anion transporter family, member 1a4
chr6_+_122006798 12.95 ENSMUST00000081777.6
Mug2
murinoglobulin 2
chr19_+_37697792 10.45 ENSMUST00000025946.5
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
chr15_+_6445320 9.32 ENSMUST00000022749.9
C9
complement component 9
chr10_+_79890853 7.88 ENSMUST00000061653.7
Cfd
complement factor D (adipsin)
chr16_+_23107413 5.50 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2
eukaryotic translation initiation factor 4A2
chrX_-_139782353 5.47 ENSMUST00000101217.3
Ripply1
ripply1 homolog (zebrafish)
chr9_-_43239816 5.10 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr5_-_151190154 5.02 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13
StAR-related lipid transfer (START) domain containing 13
chr1_-_105356658 4.98 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152
ring finger protein 152
chr1_-_51915968 4.85 ENSMUST00000046390.7
Myo1b
myosin IB
chr10_-_24101951 4.63 ENSMUST00000170267.1
Taar8c
trace amine-associated receptor 8C
chr14_-_30943275 4.34 ENSMUST00000006704.8
ENSMUST00000163118.1
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr2_-_148045891 4.24 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr19_-_42202150 4.13 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr3_-_107943705 3.98 ENSMUST00000106680.1
ENSMUST00000106684.1
ENSMUST00000106685.2
Gstm6
glutathione S-transferase, mu 6
chr6_+_116264186 3.86 ENSMUST00000036503.7
ENSMUST00000112900.3
Zfand4
zinc finger, AN1-type domain 4
chr2_+_160880642 3.74 ENSMUST00000109456.2
Lpin3
lipin 3
chr1_+_88138364 3.71 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr4_-_103214791 3.69 ENSMUST00000094947.2
ENSMUST00000036195.6
Slc35d1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr10_-_120899067 3.58 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_-_175703646 3.39 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245
predicted gene 4245
chr7_+_79810727 3.31 ENSMUST00000107394.1
Mesp2
mesoderm posterior 2
chr2_+_175372436 3.25 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723
predicted gene 4723
chrX_+_101383726 3.20 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr1_+_131970589 3.17 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr7_+_45259031 3.15 ENSMUST00000179310.1
Slc6a16
solute carrier family 6, member 16
chr5_-_5514730 3.06 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
Cldn12
claudin 12
chr11_+_103101682 3.05 ENSMUST00000107040.3
ENSMUST00000140372.1
ENSMUST00000024492.8
ENSMUST00000134884.1
Acbd4
acyl-Coenzyme A binding domain containing 4
chr17_+_3397189 3.02 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr9_-_45204083 3.02 ENSMUST00000034599.8
Tmprss4
transmembrane protease, serine 4
chr5_-_108132513 2.96 ENSMUST00000119784.1
ENSMUST00000117759.1
Tmed5
transmembrane emp24 protein transport domain containing 5
chr1_-_52500679 2.92 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr5_-_5514873 2.88 ENSMUST00000060947.7
Cldn12
claudin 12
chr19_-_28963863 2.85 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr3_-_115715031 2.80 ENSMUST00000055676.2
S1pr1
sphingosine-1-phosphate receptor 1
chr15_-_81360739 2.72 ENSMUST00000023040.7
Slc25a17
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr4_-_49549523 2.61 ENSMUST00000029987.9
Aldob
aldolase B, fructose-bisphosphate
chr1_-_138847579 2.60 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9
LIM homeobox protein 9
chrX_+_42502533 2.38 ENSMUST00000005839.4
Sh2d1a
SH2 domain protein 1A
chr2_+_175469985 2.32 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923
predicted gene 8923
chr4_+_41465134 2.28 ENSMUST00000030154.6
Nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr4_+_53440516 2.16 ENSMUST00000107651.2
ENSMUST00000107647.1
Slc44a1
solute carrier family 44, member 1
chr5_+_120513102 2.14 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr6_-_94700137 2.13 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
chr13_-_113180897 2.11 ENSMUST00000038212.7
Gzmk
granzyme K
chr14_+_51893610 2.10 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr1_+_164115264 2.10 ENSMUST00000162746.1
Selp
selectin, platelet
chr14_-_55643251 2.04 ENSMUST00000120041.1
ENSMUST00000121937.1
ENSMUST00000133707.1
ENSMUST00000002391.8
ENSMUST00000121791.1
Tm9sf1
transmembrane 9 superfamily member 1
chr7_+_105404568 2.04 ENSMUST00000033187.4
Cnga4
cyclic nucleotide gated channel alpha 4
chr10_+_106470281 2.04 ENSMUST00000029404.9
ENSMUST00000169303.1
Ppfia2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr7_+_27607997 2.03 ENSMUST00000142365.1
Akt2
thymoma viral proto-oncogene 2
chr6_+_50110837 2.03 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr18_+_84088077 2.02 ENSMUST00000060223.2
Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr3_+_60031754 2.01 ENSMUST00000029325.3
Aadac
arylacetamide deacetylase (esterase)
chr3_-_84220853 1.97 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
Trim2
tripartite motif-containing 2
chr12_+_84642896 1.95 ENSMUST00000095551.4
Vrtn
vertebrae development associated
chr13_+_112464070 1.91 ENSMUST00000183663.1
ENSMUST00000184311.1
ENSMUST00000183886.1
Il6st
interleukin 6 signal transducer
chr2_-_103797617 1.91 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr7_-_28302238 1.90 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr1_+_131599239 1.89 ENSMUST00000027690.6
Avpr1b
arginine vasopressin receptor 1B
chr5_-_108132541 1.87 ENSMUST00000119437.1
ENSMUST00000118036.1
Tmed5
transmembrane emp24 protein transport domain containing 5
chr13_+_80886095 1.86 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr1_-_157108632 1.86 ENSMUST00000118207.1
ENSMUST00000027884.6
ENSMUST00000121911.1
Tex35
testis expressed 35
chr10_+_97693053 1.85 ENSMUST00000060703.4
Ccer1
coiled coil glutamate rich protein 1
chr14_-_11162008 1.82 ENSMUST00000162278.1
ENSMUST00000160340.1
ENSMUST00000160956.1
Fhit
fragile histidine triad gene
chr9_-_48495321 1.81 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr4_+_125490688 1.80 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr11_-_84068766 1.76 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr13_+_54503779 1.73 ENSMUST00000121401.1
ENSMUST00000118072.1
ENSMUST00000159721.1
Simc1
SUMO-interacting motifs containing 1
chr1_-_87089928 1.69 ENSMUST00000027455.6
Alppl2
alkaline phosphatase, placental-like 2
chr5_+_96209463 1.68 ENSMUST00000117766.1
Mrpl1
mitochondrial ribosomal protein L1
chr16_-_38713235 1.66 ENSMUST00000023487.4
Arhgap31
Rho GTPase activating protein 31
chr9_-_22131801 1.66 ENSMUST00000069330.6
Acp5
acid phosphatase 5, tartrate resistant
chr9_+_48495345 1.63 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr7_+_27607748 1.55 ENSMUST00000136962.1
Akt2
thymoma viral proto-oncogene 2
chr4_+_53440388 1.52 ENSMUST00000102911.3
ENSMUST00000107646.2
Slc44a1
solute carrier family 44, member 1
chr15_-_10470490 1.52 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr1_+_132316112 1.51 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2
NUAK family, SNF1-like kinase, 2
chr6_+_83054653 1.46 ENSMUST00000092618.6
Aup1
ancient ubiquitous protein 1
chr3_-_145649970 1.41 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr5_-_108132577 1.37 ENSMUST00000061203.6
ENSMUST00000002837.4
Tmed5
transmembrane emp24 protein transport domain containing 5
chr19_+_8840519 1.36 ENSMUST00000086058.6
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr4_+_94614483 1.35 ENSMUST00000030311.4
ENSMUST00000107104.2
Ift74
intraflagellar transport 74
chr4_+_116221590 1.31 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_-_91182848 1.28 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd
MAP-kinase activating death domain
chr2_+_54436317 1.26 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr9_-_85749308 1.24 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr1_-_172082757 1.23 ENSMUST00000003550.4
Ncstn
nicastrin
chr3_+_32436376 1.20 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr11_+_23306884 1.18 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr2_+_52857844 1.17 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2
formin-like 2
chr1_-_172329261 1.16 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr4_-_58785722 1.16 ENSMUST00000059608.2
Olfr267
olfactory receptor 267
chr2_+_10047838 1.15 ENSMUST00000181588.1
C630004M23Rik
RIKEN cDNA C630004M23 gene
chr7_-_137314394 1.15 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3
early B cell factor 3
chr7_-_108930151 1.12 ENSMUST00000055745.3
Nlrp10
NLR family, pyrin domain containing 10
chr1_+_170214826 1.12 ENSMUST00000159201.1
ENSMUST00000055830.1
4930500M09Rik
RIKEN cDNA 4930500M09 gene
chr4_+_116221633 1.11 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr9_+_54980880 1.10 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr10_+_90576252 1.08 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_+_54436432 1.07 ENSMUST00000136642.1
Galnt13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr11_+_58104229 1.05 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8
CCR4-NOT transcription complex, subunit 8
chr17_+_36145018 1.05 ENSMUST00000173025.1
ENSMUST00000056774.9
2410017I17Rik
RIKEN cDNA 2410017I17 gene
chr18_-_60591783 1.04 ENSMUST00000056533.7
Myoz3
myozenin 3
chr7_+_133637686 1.01 ENSMUST00000128901.2
2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr19_+_4003334 1.01 ENSMUST00000025806.3
Doc2g
double C2, gamma
chr4_+_84884366 0.99 ENSMUST00000102819.3
Cntln
centlein, centrosomal protein
chr11_-_84068357 0.95 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chrX_+_152001845 0.95 ENSMUST00000026289.3
ENSMUST00000112617.3
Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
chr17_+_46681038 0.94 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr11_-_23895208 0.93 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg
poly(A) polymerase gamma
chr13_+_40704005 0.92 ENSMUST00000069457.1
Gm9979
predicted gene 9979
chr2_-_164828529 0.88 ENSMUST00000017911.3
Spata25
spermatogenesis associated 25
chrX_+_42502596 0.85 ENSMUST00000115070.1
ENSMUST00000153948.1
Sh2d1a
SH2 domain protein 1A
chr6_-_142008745 0.84 ENSMUST00000111832.1
Gm6614
predicted gene 6614
chr10_+_96136603 0.84 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr9_+_19641224 0.81 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr4_+_42950369 0.80 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_-_31634592 0.79 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29
B cell receptor associated protein 29
chr1_+_172082509 0.78 ENSMUST00000135192.1
Copa
coatomer protein complex subunit alpha
chr15_-_99967067 0.77 ENSMUST00000100209.4
Fam186a
family with sequence similarity 186, member A
chr7_+_45486360 0.74 ENSMUST00000107758.1
Tulp2
tubby-like protein 2
chr15_+_79229140 0.73 ENSMUST00000163571.1
Pick1
protein interacting with C kinase 1
chr1_+_152954966 0.73 ENSMUST00000043313.8
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr7_-_30563184 0.71 ENSMUST00000043898.6
Psenen
presenilin enhancer 2 homolog (C. elegans)
chr1_+_172082796 0.69 ENSMUST00000027833.5
Copa
coatomer protein complex subunit alpha
chr6_+_15196949 0.67 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2
forkhead box P2
chr8_+_107119110 0.64 ENSMUST00000046116.1
C630050I24Rik
RIKEN cDNA C630050I24 gene
chr13_+_13590402 0.59 ENSMUST00000110559.1
Lyst
lysosomal trafficking regulator
chr2_+_164823001 0.56 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr6_+_42286676 0.56 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr4_+_42035113 0.55 ENSMUST00000098127.1
Gm10597
predicted gene 10597
chr11_+_23306910 0.55 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr6_+_42286709 0.54 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr16_+_19028232 0.44 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr4_+_148000722 0.41 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr4_+_116221689 0.37 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_+_68861564 0.35 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr7_-_79793788 0.34 ENSMUST00000032760.5
Mesp1
mesoderm posterior 1
chr1_-_71414881 0.33 ENSMUST00000087268.5
Abca12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_-_158562199 0.31 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr17_+_71552031 0.30 ENSMUST00000124001.1
ENSMUST00000167641.1
ENSMUST00000064420.5
Spdya
speedy homolog A (Xenopus laevis)
chr5_+_32136458 0.26 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr7_+_3645267 0.24 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr2_+_152081529 0.22 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr14_+_53616315 0.20 ENSMUST00000180972.1
ENSMUST00000185023.1
Trav12-2
T cell receptor alpha variable 12-2
chr9_-_54647199 0.18 ENSMUST00000128163.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr4_+_84884276 0.17 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr3_+_96104498 0.16 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
Otud7b
OTU domain containing 7B
chr16_-_32868325 0.15 ENSMUST00000089684.3
ENSMUST00000040986.8
ENSMUST00000115105.2
1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr7_+_105425817 0.15 ENSMUST00000181339.1
ENSMUST00000033189.4
Cckbr
cholecystokinin B receptor
chr13_-_103096818 0.14 ENSMUST00000166336.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_+_28071230 0.13 ENSMUST00000138392.1
ENSMUST00000076648.7
Fcgbp
Fc fragment of IgG binding protein
chr2_+_68861433 0.12 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr8_-_93535707 0.09 ENSMUST00000077816.6
Ces5a
carboxylesterase 5A
chr4_-_141874879 0.09 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr2_-_60673654 0.08 ENSMUST00000059888.8
ENSMUST00000154764.1
Itgb6
integrin beta 6
chr1_-_173741717 0.07 ENSMUST00000127730.1
AI607873
expressed sequence AI607873
chr10_-_128211788 0.05 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4
chrX_-_134474986 0.03 ENSMUST00000113223.2
Taf7l
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_+_101681487 0.03 ENSMUST00000179929.1
ENSMUST00000127504.1
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_-_108154871 0.02 ENSMUST00000062028.1
Gpr61
G protein-coupled receptor 61
chr4_+_114680769 0.02 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr4_+_84884418 0.02 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chrX_+_169685191 0.01 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1
midline 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 36.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
2.6 10.4 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.4 4.2 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
1.4 4.1 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
1.3 5.0 GO:0097498 endothelial tube lumen extension(GO:0097498)
1.1 17.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.9 2.8 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.9 3.6 GO:0030091 protein repair(GO:0030091)
0.8 3.2 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.7 2.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.7 2.6 GO:0061625 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.6 1.9 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.6 1.9 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.6 3.6 GO:0071486 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.5 5.9 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.5 3.7 GO:0008078 mesodermal cell migration(GO:0008078)
0.5 2.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.5 1.9 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.5 3.7 GO:0015871 choline transport(GO:0015871)
0.4 1.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 1.9 GO:0007386 compartment pattern specification(GO:0007386)
0.4 3.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.4 14.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 6.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.3 3.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 1.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.3 1.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 0.8 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.4 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2 1.8 GO:0015961 diadenosine polyphosphate catabolic process(GO:0015961)
0.2 1.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.2 2.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 3.2 GO:0006968 cellular defense response(GO:0006968)
0.2 2.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 0.2 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 0.7 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 2.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.9 GO:0007220 Notch receptor processing(GO:0007220)
0.1 2.0 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 1.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.6 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 1.1 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 5.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.7 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 3.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 1.5 GO:0030157 pancreatic juice secretion(GO:0030157)
0.1 1.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.3 GO:0035627 ceramide transport(GO:0035627)
0.1 3.7 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 2.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 1.4 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.4 GO:1903764 positive regulation of delayed rectifier potassium channel activity(GO:1902261) regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.7 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 8.4 GO:0060349 bone morphogenesis(GO:0060349)
0.1 1.5 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 2.1 GO:0006829 zinc II ion transport(GO:0006829)
0.0 4.9 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 2.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.9 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 2.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 9.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 2.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 1.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 2.8 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 1.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.9 36.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.6 1.9 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.5 2.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.5 2.6 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 1.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.3 1.5 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 2.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.7 GO:0098842 postsynaptic early endosome(GO:0098842)
0.2 1.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 1.7 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 3.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 6.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 1.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 4.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.2 GO:0005922 connexon complex(GO:0005922)
0.1 2.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 2.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 5.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 5.0 GO:0005811 lipid particle(GO:0005811)
0.0 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.9 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 6.3 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)
0.0 17.3 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 36.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
3.5 10.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.9 2.7 GO:0080122 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.8 3.2 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.7 2.0 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.6 13.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.6 1.9 GO:0019981 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.6 3.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.6 3.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 2.1 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.5 3.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.5 2.1 GO:0042806 fucose binding(GO:0042806)
0.5 1.9 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.5 4.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.5 1.8 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.4 3.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.3 2.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 2.0 GO:0005223 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.3 2.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 1.7 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 4.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 1.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 1.7 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 2.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 1.9 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 1.0 GO:0051373 FATZ binding(GO:0051373)
0.2 3.2 GO:0005243 gap junction channel activity(GO:0005243)
0.2 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 4.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.7 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 2.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 17.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 2.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.3 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.1 2.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 3.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 5.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 4.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 4.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0042166 acetylcholine binding(GO:0042166)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.1 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 6.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.2 GO:0017048 Rho GTPase binding(GO:0017048)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 39.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 3.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 6.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.8 PID S1P S1P3 PATHWAY S1P3 pathway
0.1 4.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 1.9 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID ARF 3PATHWAY Arf1 pathway
0.0 3.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 3.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.5 9.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.4 10.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.3 3.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 6.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 7.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 3.6 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 4.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 2.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 3.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 1.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.9 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 1.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 4.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 9.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 2.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 3.6 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis