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GSE58827: Dynamics of the Mouse Liver
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Results for Tbx2
Z-value: 1.35
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Transcription factors associated with Tbx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx2 | mm10_v2_chr11_+_85832551_85832551 | -0.63 | 3.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_130826676 Show fit | 18.75 |
ENSMUST00000027675.7
|
polymeric immunoglobulin receptor |
|
| chr1_+_130826762 Show fit | 17.86 |
ENSMUST00000133792.1
|
polymeric immunoglobulin receptor |
|
| chr6_-_141856171 Show fit | 13.53 |
ENSMUST00000165990.1
ENSMUST00000163678.1 |
solute carrier organic anion transporter family, member 1a4 |
|
| chr6_+_122006798 Show fit | 12.95 |
ENSMUST00000081777.6
|
murinoglobulin 2 |
|
| chr19_+_37697792 Show fit | 10.45 |
ENSMUST00000025946.5
|
cytochrome P450, family 26, subfamily a, polypeptide 1 |
|
| chr15_+_6445320 Show fit | 9.32 |
ENSMUST00000022749.9
|
complement component 9 |
|
| chr10_+_79890853 Show fit | 7.88 |
ENSMUST00000061653.7
|
complement factor D (adipsin) |
|
| chr16_+_23107413 Show fit | 5.50 |
ENSMUST00000023599.6
ENSMUST00000168891.1 |
eukaryotic translation initiation factor 4A2 |
|
| chrX_-_139782353 Show fit | 5.47 |
ENSMUST00000101217.3
|
ripply1 homolog (zebrafish) |
|
| chr9_-_43239816 Show fit | 5.10 |
ENSMUST00000034512.5
|
OAF homolog (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 36.6 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 1.1 | 17.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 14.4 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 2.6 | 10.4 | GO:0016103 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) |
| 0.0 | 9.3 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 8.4 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 0.3 | 6.2 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.5 | 5.9 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.1 | 5.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 1.3 | 5.0 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 36.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 17.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 2.3 | 9.3 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.0 | 6.3 | GO:0031301 | integral component of organelle membrane(GO:0031301) |
| 0.2 | 6.2 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 5.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 5.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 4.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 3.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 3.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 36.6 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.1 | 17.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 13.5 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 3.5 | 10.4 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 0.0 | 6.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 5.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 4.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.5 | 4.6 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.1 | 4.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.2 | 4.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 39.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 6.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 3.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 3.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.8 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 1.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 1.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 9.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 9.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 7.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 7.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 6.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 4.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 4.2 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.3 | 3.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 3.6 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |