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GSE58827: Dynamics of the Mouse Liver

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Results for Sox4

Z-value: 1.47

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Transcription factors associated with Sox4

Gene Symbol Gene ID Gene Info
Sox4
ENSMUSG00000076431.4 SRY (sex determining region Y)-box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_289537130.711.5e-06Click!

Activity profile of Sox4 motif

Sorted Z-values of Sox4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_103853199 16.95 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chrX_+_73639414 16.81 ENSMUST00000019701.8
Dusp9
dual specificity phosphatase 9
chr4_+_115057683 13.52 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr9_-_103480328 11.39 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr15_+_102296256 9.38 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr5_+_115908644 9.10 ENSMUST00000141101.1
Cit
citron
chr15_-_79285502 8.70 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr7_+_45216671 8.32 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr7_+_100493795 8.14 ENSMUST00000129324.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr7_-_100514800 8.06 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr15_-_79285470 7.90 ENSMUST00000170955.1
Baiap2l2
BAI1-associated protein 2-like 2
chr13_+_117220584 7.83 ENSMUST00000022242.7
Emb
embigin
chr7_+_100494044 7.51 ENSMUST00000153287.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr12_+_24831583 7.39 ENSMUST00000110942.3
ENSMUST00000078902.6
Mboat2
membrane bound O-acyltransferase domain containing 2
chr5_-_122050102 7.09 ENSMUST00000154139.1
Cux2
cut-like homeobox 2
chr10_-_116473875 5.91 ENSMUST00000068233.4
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr19_+_34922351 5.84 ENSMUST00000087341.5
Kif20b
kinesin family member 20B
chr17_+_12119274 5.78 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chrX_+_164090187 5.46 ENSMUST00000015545.3
Tmem27
transmembrane protein 27
chr19_-_46327121 5.41 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd
pleckstrin and Sec7 domain containing
chr12_+_24708984 4.91 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr8_-_4259257 4.78 ENSMUST00000053252.7
Ctxn1
cortexin 1
chrX_+_159840463 4.75 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1
SH3-domain kinase binding protein 1
chr16_+_17146937 4.74 ENSMUST00000115706.1
ENSMUST00000069064.4
Ydjc
YdjC homolog (bacterial)
chr15_-_36879816 4.55 ENSMUST00000100713.2
Gm10384
predicted gene 10384
chr18_-_15063560 4.42 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr3_+_131110350 4.39 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
Lef1
lymphoid enhancer binding factor 1
chr3_-_50443603 4.21 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr17_-_79355082 4.04 ENSMUST00000068958.7
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr12_-_54986363 3.95 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr3_+_8509477 3.81 ENSMUST00000029002.7
Stmn2
stathmin-like 2
chr18_+_82554463 3.71 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
Mbp
myelin basic protein
chr9_-_111057235 3.66 ENSMUST00000111888.1
Ccrl2
chemokine (C-C motif) receptor-like 2
chr17_+_75005523 3.63 ENSMUST00000001927.5
Ltbp1
latent transforming growth factor beta binding protein 1
chr11_+_54314896 3.58 ENSMUST00000072178.4
ENSMUST00000101211.2
ENSMUST00000101213.2
Acsl6
acyl-CoA synthetase long-chain family member 6
chr5_+_44100442 3.54 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr18_+_56707725 3.42 ENSMUST00000025486.8
Lmnb1
lamin B1
chr11_+_69846610 3.29 ENSMUST00000152566.1
ENSMUST00000108633.2
Plscr3
phospholipid scramblase 3
chr5_-_131538687 3.22 ENSMUST00000161374.1
Auts2
autism susceptibility candidate 2
chr11_+_69846665 3.10 ENSMUST00000019605.2
Plscr3
phospholipid scramblase 3
chr12_-_54986328 2.93 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chrX_-_145505175 2.91 ENSMUST00000143610.1
Amot
angiomotin
chr6_+_17065129 2.81 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
Tes
testis derived transcript
chr13_-_97747399 2.77 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_+_69846374 2.76 ENSMUST00000108632.1
Plscr3
phospholipid scramblase 3
chr8_-_11635745 2.73 ENSMUST00000033905.5
ENSMUST00000169782.1
Ankrd10
ankyrin repeat domain 10
chr16_-_91044473 2.60 ENSMUST00000118522.1
Paxbp1
PAX3 and PAX7 binding protein 1
chr1_+_135729147 2.54 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr4_+_127021311 2.52 ENSMUST00000030623.7
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr13_-_97747373 2.49 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_+_54314960 2.38 ENSMUST00000064690.3
ENSMUST00000108899.1
Acsl6
acyl-CoA synthetase long-chain family member 6
chrX_-_145505136 2.30 ENSMUST00000112835.1
Amot
angiomotin
chr17_-_68004075 2.14 ENSMUST00000024840.5
Arhgap28
Rho GTPase activating protein 28
chr11_-_98625661 2.10 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr6_-_16898441 2.10 ENSMUST00000031533.7
Tfec
transcription factor EC
chr18_-_36766198 2.09 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr6_-_47594967 2.05 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
Ezh2
enhancer of zeste homolog 2 (Drosophila)
chr15_-_79254737 2.05 ENSMUST00000039752.3
Slc16a8
solute carrier family 16 (monocarboxylic acid transporters), member 8
chr6_-_99726392 2.04 ENSMUST00000032152.8
ENSMUST00000101120.4
ENSMUST00000008273.6
Prok2
prokineticin 2
chr5_+_25246775 1.93 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr7_+_99466004 1.87 ENSMUST00000037359.2
Klhl35
kelch-like 35
chr11_+_101442298 1.81 ENSMUST00000077856.6
Rpl27
ribosomal protein L27
chr17_-_35704574 1.69 ENSMUST00000117301.1
ENSMUST00000134995.1
Ddr1
discoidin domain receptor family, member 1
chr9_-_32541589 1.68 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr11_+_101442440 1.60 ENSMUST00000107249.1
Rpl27
ribosomal protein L27
chr5_+_19907502 1.60 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_106159902 1.58 ENSMUST00000064545.4
Limd2
LIM domain containing 2
chr3_-_95133989 1.56 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1
sodium channel modifier 1
chr6_+_4903298 1.53 ENSMUST00000035813.2
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr5_+_25247344 1.51 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr18_-_62756275 1.33 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik
RIKEN cDNA 2700046A07 gene
chr2_-_143862933 1.32 ENSMUST00000099296.3
Bfsp1
beaded filament structural protein 1, in lens-CP94
chr11_+_70432627 1.30 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
Arrb2
arrestin, beta 2
chrX_+_71556874 1.29 ENSMUST00000123100.1
Hmgb3
high mobility group box 3
chr4_+_136286061 1.26 ENSMUST00000069195.4
ENSMUST00000130658.1
Zfp46
zinc finger protein 46
chr14_+_54936456 1.25 ENSMUST00000037814.6
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr11_-_106160101 1.20 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chr1_-_153487639 1.18 ENSMUST00000042141.5
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr2_-_26910569 1.12 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22
mediator complex subunit 22
chr1_-_55027473 1.10 ENSMUST00000027127.7
Sf3b1
splicing factor 3b, subunit 1
chr4_-_129742275 1.10 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr17_-_27622785 1.04 ENSMUST00000176458.1
ENSMUST00000114886.1
Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr4_+_150148905 0.99 ENSMUST00000059893.7
Slc2a7
solute carrier family 2 (facilitated glucose transporter), member 7
chr16_+_84834901 0.95 ENSMUST00000114184.1
Gabpa
GA repeat binding protein, alpha
chrX_+_133850980 0.93 ENSMUST00000033602.8
Tnmd
tenomodulin
chr11_+_121237216 0.89 ENSMUST00000103015.3
Narf
nuclear prelamin A recognition factor
chr17_-_35697971 0.88 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr2_-_165898951 0.88 ENSMUST00000136842.1
Zmynd8
zinc finger, MYND-type containing 8
chr6_-_38875965 0.87 ENSMUST00000160360.1
Hipk2
homeodomain interacting protein kinase 2
chr1_-_36557517 0.83 ENSMUST00000114990.1
ENSMUST00000128104.1
ENSMUST00000027295.4
Sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr16_+_20516962 0.82 ENSMUST00000003318.5
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr16_+_17070220 0.79 ENSMUST00000141959.1
Ypel1
yippee-like 1 (Drosophila)
chr13_-_54749849 0.70 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr1_+_153665274 0.68 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8
regulator of G-protein signaling 8
chrX_-_10117597 0.66 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
Srpx
sushi-repeat-containing protein
chr12_-_112673944 0.61 ENSMUST00000130342.1
Akt1
thymoma viral proto-oncogene 1
chr11_-_114066174 0.55 ENSMUST00000041627.7
Sdk2
sidekick homolog 2 (chicken)
chr11_-_85139939 0.49 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chr16_+_20517000 0.49 ENSMUST00000171572.1
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr4_+_83417715 0.48 ENSMUST00000030206.3
ENSMUST00000071544.4
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr12_-_112674193 0.45 ENSMUST00000001780.3
Akt1
thymoma viral proto-oncogene 1
chr8_+_81856324 0.43 ENSMUST00000109851.2
Inpp4b
inositol polyphosphate-4-phosphatase, type II
chr2_+_32570858 0.43 ENSMUST00000140592.1
ENSMUST00000028151.6
Dpm2
dolichol-phosphate (beta-D) mannosyltransferase 2
chr5_+_20702129 0.39 ENSMUST00000101556.4
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_-_116473418 0.37 ENSMUST00000087965.4
ENSMUST00000164271.1
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr18_+_37496997 0.34 ENSMUST00000059571.5
Pcdhb19
protocadherin beta 19
chr11_-_115813621 0.34 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2
CASK-interacting protein 2
chr3_+_89164790 0.32 ENSMUST00000121212.2
ENSMUST00000152205.1
ENSMUST00000090927.5
ENSMUST00000148265.1
ENSMUST00000121931.1
Clk2
CDC-like kinase 2
chr17_-_35704000 0.32 ENSMUST00000097333.3
ENSMUST00000003628.6
Ddr1
discoidin domain receptor family, member 1
chr1_-_93101854 0.27 ENSMUST00000171796.1
ENSMUST00000171556.1
Kif1a
kinesin family member 1A
chr11_-_78497734 0.24 ENSMUST00000061174.6
Sarm1
sterile alpha and HEAT/Armadillo motif containing 1
chr5_-_24445254 0.23 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr1_-_93101825 0.23 ENSMUST00000112958.2
Kif1a
kinesin family member 1A
chr17_+_68837062 0.18 ENSMUST00000178545.1
Tmem200c
transmembrane protein 200C
chr12_-_79296266 0.15 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr5_-_114380459 0.14 ENSMUST00000001125.5
Kctd10
potassium channel tetramerisation domain containing 10
chr5_-_114380505 0.12 ENSMUST00000102581.4
Kctd10
potassium channel tetramerisation domain containing 10
chr16_+_84835070 0.11 ENSMUST00000009120.7
Gabpa
GA repeat binding protein, alpha
chr1_+_174430430 0.08 ENSMUST00000053178.4
Olfr414
olfactory receptor 414
chr6_-_39557830 0.08 ENSMUST00000036877.3
ENSMUST00000154149.1
Dennd2a
DENN/MADD domain containing 2A
chr5_-_24445166 0.03 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk
Fas-activated serine/threonine kinase
chr18_+_37300799 0.03 ENSMUST00000051754.1
Pcdhb3
protocadherin beta 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
2.7 8.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
2.1 16.9 GO:0015671 oxygen transport(GO:0015671)
1.9 5.8 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
1.3 5.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
1.2 3.7 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
1.1 3.4 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.1 4.4 GO:0061153 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.1 3.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 6.0 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
1.0 3.8 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.9 15.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.8 16.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.8 7.8 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.7 16.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.7 12.7 GO:0070307 lens fiber cell development(GO:0070307)
0.7 2.1 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.7 2.0 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.6 5.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.6 6.3 GO:0005513 detection of calcium ion(GO:0005513)
0.6 9.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.5 2.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 3.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.4 9.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.4 1.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.4 4.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.4 1.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.4 2.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 1.0 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.3 4.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.3 8.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.3 6.8 GO:0007614 short-term memory(GO:0007614)
0.3 4.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.1 GO:0060709 glycogen cell differentiation involved in embryonic placenta development(GO:0060709)
0.3 1.3 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.2 2.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 1.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 2.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 1.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 5.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 0.9 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.2 2.6 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.2 1.3 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953)
0.1 0.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 2.1 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.1 1.1 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 3.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 9.2 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 0.9 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.4 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 13.2 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.5 GO:0009301 snRNA transcription(GO:0009301)
0.0 6.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 2.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.5 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.8 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 4.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.1 GO:0001825 blastocyst formation(GO:0001825)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 0.4 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0033193 Lsd1/2 complex(GO:0033193)
2.8 8.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.1 16.9 GO:0005833 hemoglobin complex(GO:0005833)
1.7 6.9 GO:0008623 CHRAC(GO:0008623)
1.4 16.6 GO:0071439 clathrin complex(GO:0071439)
1.2 3.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.0 4.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.6 4.3 GO:0005638 lamin filament(GO:0005638)
0.5 3.7 GO:0033269 internode region of axon(GO:0033269)
0.4 5.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 4.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 2.5 GO:0042382 paraspeckles(GO:0042382)
0.3 1.5 GO:1990761 growth cone lamellipodium(GO:1990761)
0.3 14.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 2.0 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 12.7 GO:0005882 intermediate filament(GO:0005882)
0.1 9.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 5.2 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 2.1 GO:0045120 pronucleus(GO:0045120)
0.1 1.1 GO:0005686 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)
0.1 5.9 GO:0036126 sperm flagellum(GO:0036126)
0.1 6.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 5.5 GO:0031526 brush border membrane(GO:0031526)
0.1 11.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 6.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 2.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 11.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.1 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 7.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.8 GO:0030027 lamellipodium(GO:0030027)
0.0 2.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
2.6 15.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.2 7.4 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
1.1 16.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.0 5.2 GO:0043532 angiostatin binding(GO:0043532)
1.0 4.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 3.6 GO:0050436 microfibril binding(GO:0050436)
0.8 5.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.7 4.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 4.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 12.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.4 1.2 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.4 9.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 8.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 2.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 6.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 2.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 2.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 5.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 2.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 6.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 13.5 GO:0070888 E-box binding(GO:0070888)
0.2 3.7 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.2 4.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 1.0 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.2 5.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 3.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 5.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 3.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 9.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 9.1 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.9 GO:0046790 virion binding(GO:0046790)
0.1 1.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 8.1 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 4.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.9 GO:0005521 lamin binding(GO:0005521)
0.0 13.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 16.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 9.1 PID RHOA PATHWAY RhoA signaling pathway
0.1 4.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 3.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 4.9 PID E2F PATHWAY E2F transcription factor network
0.0 4.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 4.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.4 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.2 4.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 6.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 8.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 5.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 6.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 5.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 6.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 11.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 4.8 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.0 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 3.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 3.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane