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GSE58827: Dynamics of the Mouse Liver

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Results for Six4

Z-value: 0.80

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Transcription factors associated with Six4

Gene Symbol Gene ID Gene Info
Six4
ENSMUSG00000034460.8 sine oculis-related homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.134.5e-01Click!

Activity profile of Six4 motif

Sorted Z-values of Six4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_54422286 8.85 ENSMUST00000181269.1
Redrum
Redrum, erythroid developmental long intergenic non-protein coding transcript
chr15_-_103255433 7.96 ENSMUST00000075192.6
Nfe2
nuclear factor, erythroid derived 2
chr10_+_75564086 5.95 ENSMUST00000141062.1
ENSMUST00000152657.1
Ggt1
gamma-glutamyltransferase 1
chr6_+_134929118 4.68 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5
RP23-45G16.5
chr4_-_134018829 4.55 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr6_+_134929089 4.29 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5
RP23-45G16.5
chr1_+_174041933 3.95 ENSMUST00000052975.4
Olfr433
olfactory receptor 433
chr14_-_89898466 3.75 ENSMUST00000081204.4
Gm10110
predicted gene 10110
chr14_-_56085214 3.65 ENSMUST00000015594.7
Mcpt8
mast cell protease 8
chr2_+_131491764 3.61 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox
spermine oxidase
chr17_+_25369267 2.83 ENSMUST00000160377.1
ENSMUST00000160485.1
Tpsg1
tryptase gamma 1
chr15_-_66831625 2.83 ENSMUST00000164163.1
Sla
src-like adaptor
chr7_-_143460989 2.73 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c
cyclin-dependent kinase inhibitor 1C (P57)
chr1_-_180813534 2.37 ENSMUST00000159789.1
ENSMUST00000081026.4
H3f3a
H3 histone, family 3A
chr17_+_35049966 2.09 ENSMUST00000007257.9
Clic1
chloride intracellular channel 1
chr17_-_48409729 1.91 ENSMUST00000160319.1
ENSMUST00000159535.1
ENSMUST00000078800.6
ENSMUST00000046719.7
ENSMUST00000162460.1
Nfya
nuclear transcription factor-Y alpha
chr8_+_94377911 1.85 ENSMUST00000159142.1
Gm15889
predicted gene 15889
chr11_+_85312164 1.84 ENSMUST00000127717.1
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chr19_+_6400523 1.81 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
Rasgrp2
RAS, guanyl releasing protein 2
chr19_-_10974664 1.75 ENSMUST00000072748.6
Ms4a10
membrane-spanning 4-domains, subfamily A, member 10
chr1_-_180813591 1.73 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a
H3 histone, family 3A
chr19_+_6400611 1.67 ENSMUST00000113467.1
Rasgrp2
RAS, guanyl releasing protein 2
chr11_-_45955465 1.57 ENSMUST00000011398.6
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr11_-_45955183 1.55 ENSMUST00000109254.1
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr8_+_94214567 1.47 ENSMUST00000079961.6
Nup93
nucleoporin 93
chr13_-_76385028 1.41 ENSMUST00000099365.1
Gm10760
predicted gene 10760
chrX_-_139714481 1.39 ENSMUST00000183728.1
Gm15013
predicted gene 15013
chr1_+_21272338 1.27 ENSMUST00000178379.1
Gm7094
predicted pseudogene 7094
chr6_-_72380416 1.25 ENSMUST00000101285.3
ENSMUST00000074231.3
Vamp5
vesicle-associated membrane protein 5
chr1_-_78968079 1.22 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr11_-_71142366 1.16 ENSMUST00000048514.4
Nlrp1a
NLR family, pyrin domain containing 1A
chr11_+_67078293 1.12 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
Myh3
myosin, heavy polypeptide 3, skeletal muscle, embryonic
chr3_-_129831374 1.07 ENSMUST00000029643.8
Gar1
GAR1 ribonucleoprotein homolog (yeast)
chr15_-_79834224 1.03 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
Cbx6
Npcd
chromobox 6
neuronal pentraxin chromo domain
chr10_-_80918212 1.00 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2
lamin B2
chr10_+_79755103 0.95 ENSMUST00000020577.2
Fgf22
fibroblast growth factor 22
chr19_+_8764934 0.94 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr2_+_131133497 0.92 ENSMUST00000110225.1
Gm11037
predicted gene 11037
chr2_-_93452679 0.92 ENSMUST00000111257.1
ENSMUST00000145553.1
Cd82
CD82 antigen
chr1_+_54250673 0.91 ENSMUST00000027128.4
Ccdc150
coiled-coil domain containing 150
chr15_-_79834261 0.89 ENSMUST00000148358.1
Cbx6
chromobox 6
chr8_+_95703037 0.88 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4
N-myc downstream regulated gene 4
chr2_-_10048580 0.86 ENSMUST00000026888.4
Taf3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr4_+_129906205 0.84 ENSMUST00000145196.1
ENSMUST00000141731.1
ENSMUST00000129149.1
E330017L17Rik
RIKEN cDNA E330017L17 gene
chr8_-_85067982 0.81 ENSMUST00000177563.1
Gm5741
predicted gene 5741
chr18_-_38250558 0.78 ENSMUST00000181757.1
1700086O06Rik
RIKEN cDNA 1700086O06 gene
chr1_-_37890333 0.75 ENSMUST00000139725.1
ENSMUST00000027257.8
Mitd1
MIT, microtubule interacting and transport, domain containing 1
chr13_+_51645232 0.69 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr10_-_76442758 0.62 ENSMUST00000001179.5
Pcnt
pericentrin (kendrin)
chr1_+_171839694 0.58 ENSMUST00000155802.1
Cd84
CD84 antigen
chr11_+_3989924 0.58 ENSMUST00000109981.1
Gal3st1
galactose-3-O-sulfotransferase 1
chr1_+_37890477 0.54 ENSMUST00000027256.5
Mrpl30
mitochondrial ribosomal protein L30
chr3_+_138352378 0.49 ENSMUST00000090166.4
Adh6b
alcohol dehydrogenase 6B (class V)
chr3_+_145938004 0.49 ENSMUST00000039571.7
2410004B18Rik
RIKEN cDNA 2410004B18 gene
chr7_+_29307924 0.49 ENSMUST00000108230.1
ENSMUST00000065181.5
Dpf1
D4, zinc and double PHD fingers family 1
chr6_+_115134899 0.36 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2
synapsin II
chr6_+_149130170 0.32 ENSMUST00000087348.3
Gm10203
predicted gene 10203
chr1_-_131200089 0.29 ENSMUST00000068564.8
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr12_-_41485751 0.22 ENSMUST00000043884.4
Lrrn3
leucine rich repeat protein 3, neuronal
chr7_-_104893626 0.18 ENSMUST00000081116.1
Olfr666
olfactory receptor 666
chrX_-_150440887 0.18 ENSMUST00000163233.1
Tmem29
transmembrane protein 29
chr19_+_29410919 0.14 ENSMUST00000112576.2
Pdcd1lg2
programmed cell death 1 ligand 2
chr3_-_30969399 0.10 ENSMUST00000177992.1
ENSMUST00000129817.2
ENSMUST00000168645.1
ENSMUST00000108255.1
ENSMUST00000064718.5
ENSMUST00000099163.3
Phc3
polyhomeotic-like 3 (Drosophila)
chr16_+_11405648 0.10 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr7_-_132317198 0.10 ENSMUST00000080215.5
Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr17_+_48409980 0.08 ENSMUST00000167180.1
ENSMUST00000046651.6
Oard1
O-acyl-ADP-ribose deacylase 1
chr10_-_130455894 0.07 ENSMUST00000170257.2
Vmn2r86
vomeronasal 2, receptor 86
chr2_+_10047838 0.07 ENSMUST00000181588.1
C630004M23Rik
RIKEN cDNA C630004M23 gene
chr17_+_24896488 0.05 ENSMUST00000024978.6
Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr4_-_144786551 0.04 ENSMUST00000105746.2
Gm438
predicted gene 438
chr10_-_3267768 0.03 ENSMUST00000170893.2
H60c
histocompatibility 60c
chr1_-_74284636 0.03 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp
angio-associated migratory protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Six4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.7 6.0 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.7 8.0 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.5 3.6 GO:0046208 spermine catabolic process(GO:0046208)
0.5 4.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.3 2.7 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.3 1.5 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 1.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 0.6 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.1 1.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 3.9 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.1 0.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 3.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 3.1 GO:0006400 tRNA modification(GO:0006400)
0.0 1.2 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 1.9 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.9 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 2.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 2.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.5 GO:1990403 embryonic brain development(GO:1990403)
0.0 1.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.8 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.1 GO:0001740 Barr body(GO:0001740)
0.3 1.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.1 GO:0001651 dense fibrillar component(GO:0001651)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.1 0.9 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 4.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 1.1 GO:0032982 myosin filament(GO:0032982)
0.0 8.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.6 GO:0031201 SNARE complex(GO:0031201)
0.0 2.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
1.0 3.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.5 6.0 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.4 4.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.4 1.8 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 0.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 2.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 8.0 GO:0050699 WW domain binding(GO:0050699)
0.2 1.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 4.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 4.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.2 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 3.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 1.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 12.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.4 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.9 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism