GSE58827: Dynamics of the Mouse Liver


Results for Prdm14

Z-value: 0.95

Motif logo

Transcription factors associated with Prdm14

Gene Symbol Gene ID Gene Info
ENSMUSG00000042414.7 PR domain containing 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Prdm14 motif

Sorted Z-values of Prdm14 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_93048192 5.79 ENSMUST00000095211.4
carboxylesterase 1A
chr6_-_138043411 5.06 ENSMUST00000111873.1
solute carrier family 15, member 5
chr16_+_43235856 4.66 ENSMUST00000146708.1
zinc finger and BTB domain containing 20
chr1_+_88134786 4.42 ENSMUST00000113134.1
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr15_-_76307231 4.32 ENSMUST00000023222.6
5-oxoprolinase (ATP-hydrolysing)
chr15_-_76307101 4.20 ENSMUST00000171340.1
5-oxoprolinase (ATP-hydrolysing)
chr1_+_191977368 4.13 ENSMUST00000181512.1
retinal degeneration 3
chr4_+_133553370 4.04 ENSMUST00000042706.2
nuclear receptor subfamily 0, group B, member 2
chr1_+_88103229 4.04 ENSMUST00000113135.3
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr15_-_50890396 3.78 ENSMUST00000185183.1
trichorhinophalangeal syndrome I (human)
chr6_+_54039558 3.46 ENSMUST00000046856.7
chimerin (chimaerin) 2
chr6_+_91684061 2.45 ENSMUST00000032185.7
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr17_-_34862122 2.12 ENSMUST00000154526.1
complement factor B
chr7_+_114745685 2.07 ENSMUST00000136645.1
inscuteable homolog (Drosophila)
chr4_+_155562348 2.04 ENSMUST00000030939.7
NAD kinase
chr17_-_34862473 1.90 ENSMUST00000025229.4
complement factor B
chr6_+_72355425 1.83 ENSMUST00000069695.2
transmembrane protein 150A
chr14_-_72709986 1.79 ENSMUST00000089017.5
fibronectin type III domain containing 3A
chr19_-_6067785 1.74 ENSMUST00000162575.1
transmembrane 7 superfamily member 2
chr11_-_35980473 1.61 ENSMUST00000018993.6
WW, C2 and coiled-coil domain containing 1
chr14_+_62760496 1.45 ENSMUST00000181344.1
RIKEN cDNA 4931440J10 gene
chr9_-_50659780 1.43 ENSMUST00000034567.3
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr4_+_117126776 1.38 ENSMUST00000134074.1
Tctex1 domain containing 4
chr13_+_74639866 1.35 ENSMUST00000169114.1
endoplasmic reticulum aminopeptidase 1
chr8_+_46492789 1.26 ENSMUST00000110371.1
acyl-CoA synthetase long-chain family member 1
chrX_+_68761875 1.25 ENSMUST00000114647.1
fragile X mental retardation 1 neighbor
chr11_+_78324200 1.03 ENSMUST00000102478.3
aldolase C, fructose-bisphosphate
chr2_-_144011202 1.01 ENSMUST00000016072.5
ribosome binding protein 1
chr12_+_74297474 0.98 ENSMUST00000072100.3
DNA binding protein with his-thr domain
chr5_+_98254174 0.97 ENSMUST00000031280.1
fibroblast growth factor 5
chrM_+_7759 0.93 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chrX_+_68761890 0.87 ENSMUST00000071848.6
fragile X mental retardation 1 neighbor
chr9_+_94669876 0.83 ENSMUST00000033463.9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr15_-_73707387 0.80 ENSMUST00000064166.4
G protein-coupled receptor 20
chr9_-_14903752 0.77 ENSMUST00000148155.1
folate receptor 4 (delta)
chr6_+_83109071 0.77 ENSMUST00000113938.3
mitochondrial ribosomal protein L53
chr6_+_92940572 0.76 ENSMUST00000181145.1
RIKEN cDNA 9530026P05 gene
chr11_-_89302545 0.74 ENSMUST00000061728.3
chr6_-_42461017 0.74 ENSMUST00000090156.1
olfactory receptor 458
chr18_-_70530138 0.72 ENSMUST00000161542.1
polymerase (DNA directed), iota
chr9_-_14903932 0.71 ENSMUST00000034409.7
folate receptor 4 (delta)
chr1_-_64121389 0.70 ENSMUST00000055001.3
Kruppel-like factor 7 (ubiquitous)
chr1_-_59003443 0.66 ENSMUST00000054653.6
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human)
chr3_+_89136572 0.63 ENSMUST00000107482.3
pyruvate kinase liver and red blood cell
chr18_-_70530313 0.63 ENSMUST00000043286.8
polymerase (DNA directed), iota
chr15_+_99601372 0.60 ENSMUST00000023754.5
aquaporin 6
chr9_+_102718424 0.59 ENSMUST00000156485.1
angiomotin-like 2
chrX_+_68761839 0.55 ENSMUST00000069731.5
fragile X mental retardation 1 neighbor
chr4_+_117126800 0.52 ENSMUST00000062206.2
Tctex1 domain containing 4
chr6_-_39810881 0.51 ENSMUST00000114797.1
mitochondrial ribosomal protein S33
chr15_-_44428303 0.50 ENSMUST00000038719.6
NudC domain containing 1
chr10_-_128744014 0.49 ENSMUST00000026414.7
diacylglycerol kinase, alpha
chr7_+_18987518 0.48 ENSMUST00000063563.7
nanos homolog 2 (Drosophila)
chr15_+_44428073 0.40 ENSMUST00000060652.3
enhancer of yellow 2 homolog (Drosophila)
chr17_+_26781060 0.39 ENSMUST00000015725.8
BCL2/adenovirus E1B interacting protein 1
chr17_+_21093172 0.35 ENSMUST00000169389.1
predicted gene 6811
chr9_-_14903866 0.34 ENSMUST00000069408.3
folate receptor 4 (delta)
chr11_+_104685701 0.33 ENSMUST00000148007.2
predicted gene 11639
chr10_-_89257790 0.26 ENSMUST00000045601.7
anoctamin 4
chr4_+_128883549 0.20 ENSMUST00000035667.8
tripartite motif-containing 62
chr1_-_153808163 0.20 ENSMUST00000141249.1
regulator of G-protein signaling like 1
chr13_-_119950806 0.20 ENSMUST00000180768.1
RIKEN cDNA B020031M17 gene
chr7_+_27810813 0.20 ENSMUST00000080175.6
zinc finger protein 626
chr15_+_102460076 0.05 ENSMUST00000164688.1
proline rich 13
chr18_+_37307445 0.05 ENSMUST00000056712.2
protocadherin beta 4
chr4_-_133672601 0.03 ENSMUST00000062118.4
phosphatidylinositol glycan anchor biosynthesis, class V
chrX_+_13280970 0.01 ENSMUST00000000804.6
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked

Network of associatons between targets according to the STRING database.

First level regulatory network of Prdm14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.5 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 2.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.3 4.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.7 GO:0060300 regulation of cytokine activity(GO:0060300)
0.2 1.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 1.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 1.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.1 1.3 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 3.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 1.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 8.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 4.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.6 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:0044838 cell quiescence(GO:0044838)
0.1 0.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 2.5 GO:0072348 sulfur compound transport(GO:0072348)
0.1 1.8 GO:0060009 Sertoli cell development(GO:0060009)
0.1 1.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.3 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 0.5 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 2.1 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 4.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 1.0 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.0 0.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0006833 water transport(GO:0006833)
0.0 0.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 1.7 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 4.1 GO:0007601 visual perception(GO:0007601)
0.0 0.3 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.0 5.1 GO:0015833 peptide transport(GO:0015833)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 4.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 2.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 8.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.0 GO:0031501 mannosyltransferase complex(GO:0031501)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.8 2.5 GO:0030977 taurine binding(GO:0030977)
0.3 1.3 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.3 1.4 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 8.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 0.6 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 1.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 4.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 0.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 5.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 5.1 GO:0015293 symporter activity(GO:0015293)
0.0 3.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 3.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 4.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 3.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.7 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 8.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 4.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 3.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis