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GSE58827: Dynamics of the Mouse Liver
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Results for Pparg_Rxrg
Z-value: 2.98
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Transcription factors associated with Pparg_Rxrg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rxrg | mm10_v2_chr1_+_167598384_167598411 | 0.91 | 7.4e-15 | Click! |
| Pparg | mm10_v2_chr6_+_115422040_115422067 | 0.45 | 5.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_46131888 Show fit | 67.12 |
ENSMUST00000043739.3
|
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 |
|
| chr17_-_46438471 Show fit | 59.99 |
ENSMUST00000087012.5
|
solute carrier family 22 (organic anion transporter), member 7 |
|
| chr19_+_39287074 Show fit | 52.47 |
ENSMUST00000003137.8
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr9_-_46235631 Show fit | 48.08 |
ENSMUST00000118649.1
|
apolipoprotein C-III |
|
| chr9_-_46235260 Show fit | 36.17 |
ENSMUST00000121916.1
ENSMUST00000034586.2 |
apolipoprotein C-III |
|
| chr15_-_82764176 Show fit | 34.84 |
ENSMUST00000055721.4
|
cytochrome P450, family 2, subfamily d, polypeptide 40 |
|
| chr3_+_138415484 Show fit | 25.60 |
ENSMUST00000161312.1
ENSMUST00000013458.8 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
| chr3_+_138374121 Show fit | 21.87 |
ENSMUST00000171054.1
|
alcohol dehydrogenase 6 (class V), pseudogene 1 |
|
| chr9_-_15301555 Show fit | 20.76 |
ENSMUST00000034414.8
|
RIKEN cDNA 4931406C07 gene |
|
| chr15_+_82555087 Show fit | 20.00 |
ENSMUST00000068861.6
|
cytochrome P450, family 2, subfamily d, polypeptide 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pparg_Rxrg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 126.2 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 3.7 | 111.9 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 3.5 | 104.1 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 21.1 | 84.3 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 5.9 | 71.1 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 11.4 | 45.4 | GO:0071718 | sodium-independent icosanoid transport(GO:0071718) |
| 0.9 | 35.4 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 1.6 | 31.4 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 6.4 | 25.6 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 7.7 | 23.1 | GO:0061402 | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 108.7 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 106.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 89.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 7.6 | 83.8 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.8 | 69.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.4 | 60.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.0 | 31.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.1 | 21.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.8 | 20.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.4 | 19.2 | GO:0035861 | site of double-strand break(GO:0035861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 178.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 3.0 | 115.8 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 21.8 | 87.1 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 5.9 | 71.1 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 10.5 | 62.8 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 11.8 | 35.5 | GO:0005186 | pheromone activity(GO:0005186) |
| 1.9 | 26.6 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 8.5 | 25.6 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 1.0 | 24.0 | GO:0005550 | pheromone binding(GO:0005550) |
| 0.6 | 22.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 20.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 19.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 16.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 9.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 5.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 5.4 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 5.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 5.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 98.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 2.6 | 74.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 4.3 | 60.0 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 3.6 | 40.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 2.4 | 36.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 26.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 4.3 | 25.6 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 25.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.8 | 24.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 24.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |