ISMARA results: Plag1

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GSE58827: Dynamics of the Mouse Liver

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Results for Plag1

Z-value: 1.77

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Transcription factors associated with Plag1

Gene Symbol	Gene ID	Gene Info
Plag1 Ensembl NCBI MGI UniProt	ENSMUSG00000003282.3	pleiomorphic adenoma gene 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Plag1	mm10_v2_chr4_-_3938354_3938401	0.66	1.2e-05	Click!

Activity profile of Plag1 motif

Sorted Z-values of Plag1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_80000292 Show fit	10.52	ENSMUST00000088735.3	Olfm4 Ensembl NCBI MGI UniProt Show fit	olfactomedin 4
chr7_-_142657466 Show fit	10.45	ENSMUST00000097936.2 ENSMUST00000000033.5	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr11_+_11684967 Show fit	10.22	ENSMUST00000126058.1 ENSMUST00000141436.1	Ikzf1 Ensembl NCBI MGI UniProt Show fit	IKAROS family zinc finger 1
chr7_-_142659482 Show fit	9.85	ENSMUST00000121128.1	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr11_+_74619594 Show fit	9.05	ENSMUST00000100866.2	E130309D14Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA E130309D14 gene
chr16_-_18622403 Show fit	8.75	ENSMUST00000167388.1	Gp1bb Ensembl NCBI MGI UniProt Show fit	glycoprotein Ib, beta polypeptide
chr18_-_58209926 Show fit	8.63	ENSMUST00000025497.6	Fbn2 Ensembl NCBI MGI UniProt Show fit	fibrillin 2
chr10_+_75948292 Show fit	8.28	ENSMUST00000000926.2	Vpreb3 Ensembl NCBI MGI UniProt Show fit	pre-B lymphocyte gene 3
chrX_+_8271133 Show fit	8.02	ENSMUST00000127103.1 ENSMUST00000115591.1	Slc38a5 Ensembl NCBI MGI UniProt Show fit	solute carrier family 38, member 5
chr11_-_102082464 Show fit	7.94	ENSMUST00000100398.4	Mpp2 Ensembl NCBI MGI UniProt Show fit	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Plag1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	21.3	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2	12.3	GO:0033344	cholesterol efflux(GO:0033344)
3.4	10.2	GO:0045660	positive regulation of neutrophil differentiation(GO:0045660)
3.2	9.7	GO:0060217	hemangioblast cell differentiation(GO:0060217)
1.6	9.7	GO:0034441	plasma lipoprotein particle oxidation(GO:0034441)
0.3	9.0	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.7	8.7	GO:0015816	glycine transport(GO:0015816)
1.7	8.6	GO:0071694	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.6	8.4	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.8	8.3	GO:0051025	negative regulation of immunoglobulin secretion(GO:0051025)

Showing 1 to 10 of 376 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.3	GO:0043198	dendritic shaft(GO:0043198)
0.0	13.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	10.6	GO:0031941	filamentous actin(GO:0031941)
0.7	10.5	GO:0042581	specific granule(GO:0042581)
3.2	9.7	GO:0033193	Lsd1/2 complex(GO:0033193)
0.7	9.6	GO:0044327	dendritic spine head(GO:0044327)
0.4	9.5	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.6	9.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.4	8.9	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.2	8.7	GO:0035371	microtubule plus-end(GO:0035371)

Showing 1 to 10 of 157 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	21.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.3	16.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
4.0	16.1	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.3	10.2	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
1.0	9.7	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2	9.1	GO:0070888	E-box binding(GO:0070888)
0.8	8.7	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
2.2	8.6	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
0.7	7.9	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.2	7.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)

Showing 1 to 10 of 241 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	14.0	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	11.7	NABA COLLAGENS	Genes encoding collagen proteins
0.2	11.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	10.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	10.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	9.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	8.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	6.5	PID AURORA B PATHWAY	Aurora B signaling
0.1	5.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	19.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	15.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	15.8	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.6	15.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.2	11.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	10.4	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6	9.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	7.0	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	6.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	5.9	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Showing 1 to 10 of 102 entries

Results for Plag1

Z-value: 1.77

Motif logo

Transcription factors associated with Plag1

Activity-expression correlation:

Activity profile of Plag1 motif

Sorted Z-values of Plag1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Plag1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: