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GSE58827: Dynamics of the Mouse Liver
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Results for Pbx2
Z-value: 1.12
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Transcription factors associated with Pbx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx2 | mm10_v2_chr17_+_34592248_34592329 | -0.91 | 6.4e-15 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pbx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 13.2 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.1 | 11.9 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 2.7 | 10.9 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.4 | 10.9 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.2 | 9.2 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 6.5 | GO:0006695 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 6.1 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.4 | 5.5 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 1.6 | 4.9 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) |
| 0.0 | 4.4 | GO:0006869 | lipid transport(GO:0006869) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.6 | 22.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 13.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 4.1 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.2 | 3.8 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 3.8 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 3.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 3.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 3.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.3 | 14.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 4.4 | 13.2 | GO:0005186 | pheromone activity(GO:0005186) |
| 0.3 | 12.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.9 | 11.9 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 3.6 | 10.9 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.2 | 8.0 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.8 | 6.5 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.1 | 5.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.2 | 5.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 5.9 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 3.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 3.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 2.3 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 2.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.8 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 10.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.6 | 9.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.3 | 6.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.4 | 5.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 3.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 3.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 3.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 2.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 2.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |