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GSE58827: Dynamics of the Mouse Liver
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Results for Mybl2
Z-value: 1.71
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Transcription factors associated with Mybl2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mybl2 | mm10_v2_chr2_+_163054682_163054693 | 0.89 | 5.7e-13 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_86078070 Show fit | 15.68 |
ENSMUST00000032069.5
|
adducin 2 (beta) |
|
| chr7_-_24760311 Show fit | 13.87 |
ENSMUST00000063956.5
|
CD177 antigen |
|
| chr3_+_51661167 Show fit | 13.07 |
ENSMUST00000099106.3
|
microsomal glutathione S-transferase 2 |
|
| chr11_-_83286722 Show fit | 11.99 |
ENSMUST00000163961.2
|
schlafen family member 14 |
|
| chr1_-_132390301 Show fit | 11.87 |
ENSMUST00000132435.1
|
transmembrane and coiled-coil domains 2 |
|
| chr19_-_41802028 Show fit | 10.71 |
ENSMUST00000026150.8
ENSMUST00000177495.1 ENSMUST00000163265.1 |
Rho GTPase activating protein 19 |
|
| chr2_+_84988194 Show fit | 9.55 |
ENSMUST00000028466.5
|
proteoglycan 3 |
|
| chr1_-_169531343 Show fit | 9.52 |
ENSMUST00000028000.7
|
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
|
| chr5_-_24030297 Show fit | 8.98 |
ENSMUST00000101513.2
|
family with sequence similarity 126, member A |
|
| chr7_-_127137807 Show fit | 8.58 |
ENSMUST00000049931.5
|
sialophorin |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mybl2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 20.5 | GO:0019370 | leukotriene biosynthetic process(GO:0019370) |
| 0.4 | 16.3 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.6 | 15.7 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.5 | 13.8 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.4 | 12.1 | GO:0007099 | centriole replication(GO:0007099) |
| 0.7 | 12.0 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.2 | 11.9 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 1.3 | 11.7 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.6 | 11.7 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 2.4 | 9.5 | GO:0045575 | basophil activation(GO:0045575) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 18.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 1.6 | 15.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 12.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 12.5 | GO:0000793 | condensed chromosome(GO:0000793) |
| 1.1 | 11.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 11.7 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.1 | 11.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.7 | 8.6 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 1.0 | 8.0 | GO:0001940 | male pronucleus(GO:0001940) |
| 1.3 | 7.9 | GO:0032133 | chromosome passenger complex(GO:0032133) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 20.5 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.1 | 17.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 17.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 11.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 10.7 | GO:0004521 | endoribonuclease activity(GO:0004521) |
| 0.0 | 8.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.1 | 8.1 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 2.6 | 7.8 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 7.7 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 7.3 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 24.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 15.2 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 9.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 9.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 8.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.5 | 7.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 5.1 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 3.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 3.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.5 | 19.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 12.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 11.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 10.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 10.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 9.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 7.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 7.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.5 | 7.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |