GSE58827: Dynamics of the Mouse Liver


Results for Mga

Z-value: 0.95

Motif logo

Transcription factors associated with Mga

Gene Symbol Gene ID Gene Info
ENSMUSG00000033943.9 MAX gene associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Mga motif

Sorted Z-values of Mga motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_56102458 11.90 ENSMUST00000015583.1
cathepsin G
chr16_-_36408349 10.81 ENSMUST00000023619.6
stefin A2
chr11_+_116531744 5.82 ENSMUST00000106387.2
sphingosine kinase 1
chr2_+_85136355 5.44 ENSMUST00000057019.7
apelin receptor
chr11_+_116532441 5.08 ENSMUST00000106386.1
sphingosine kinase 1
chr16_+_32186192 4.92 ENSMUST00000099990.3
brain expressed gene 6
chr14_+_65805832 4.55 ENSMUST00000022612.3
PDZ binding kinase
chr19_+_47228804 4.16 ENSMUST00000111807.3
neuralized homolog 1A (Drosophila)
chr11_+_116531097 3.75 ENSMUST00000138840.1
sphingosine kinase 1
chr15_-_66801577 3.72 ENSMUST00000168589.1
src-like adaptor
chr1_+_52008210 3.58 ENSMUST00000027277.5
signal transducer and activator of transcription 4
chr3_+_124321031 3.43 ENSMUST00000058994.4
translocation associated membrane protein 1-like 1
chr7_+_13278778 3.36 ENSMUST00000098814.4
ligase I, DNA, ATP-dependent
chr6_+_5390387 3.17 ENSMUST00000183358.1
ankyrin repeat and SOCS box-containing 4
chr3_+_105870858 3.15 ENSMUST00000164730.1
adenosine A3 receptor
chr19_-_40588374 3.10 ENSMUST00000175932.1
aldehyde dehydrogenase 18 family, member A1
chr17_+_35861318 2.97 ENSMUST00000074259.8
nurim (nuclear envelope membrane protein)
chr12_+_35992900 2.90 ENSMUST00000020898.5
anterior gradient 2
chrX_+_35888808 2.77 ENSMUST00000033419.6
dedicator of cytokinesis 11
chr17_-_32403551 2.67 ENSMUST00000135618.1
RAS protein activator like 3
chr4_-_117125618 2.64 ENSMUST00000183310.1
BTB (POZ) domain containing 19
chr17_-_32403526 2.50 ENSMUST00000137458.1
RAS protein activator like 3
chr11_-_121039400 2.45 ENSMUST00000026159.5
CD7 antigen
chr7_-_3720382 2.37 ENSMUST00000078451.6
paired Ig-like receptor B
chr7_-_104390586 2.28 ENSMUST00000106828.1
tripartite motif-containing 30C
chr5_+_149265035 2.04 ENSMUST00000130144.1
arachidonate 5-lipoxygenase activating protein
chr3_+_105870898 2.02 ENSMUST00000010279.5
adenosine A3 receptor
chr2_+_3336159 1.99 ENSMUST00000115089.1
acyl-Coenzyme A binding domain containing 7
chr4_+_132564051 1.96 ENSMUST00000070690.7
platelet-activating factor receptor
chr3_+_87376381 1.88 ENSMUST00000163661.1
Fc receptor-like 1
chr6_+_123229843 1.86 ENSMUST00000112554.2
C-type lectin domain family 4, member n
chr8_+_12984246 1.71 ENSMUST00000110873.3
mcf.2 transforming sequence-like
chr11_-_8973266 1.66 ENSMUST00000154153.1
polycystic kidney disease 1 like 1
chr8_-_13677575 1.59 ENSMUST00000117551.2
RAS p21 protein activator 3
chr7_-_30880263 1.57 ENSMUST00000108125.2
CD22 antigen
chr9_-_97111117 1.55 ENSMUST00000085206.4
solute carrier family 25, member 36
chr14_+_32833955 1.48 ENSMUST00000104926.2
family with sequence similarity 170, member B
chr8_+_83165348 1.46 ENSMUST00000034145.4
TBC1 domain family, member 9
chr2_-_170131156 1.45 ENSMUST00000063710.6
zinc finger protein 217
chr6_-_41636389 1.42 ENSMUST00000031902.5
transient receptor potential cation channel, subfamily V, member 6
chr4_-_117156144 1.38 ENSMUST00000102696.4
ribosomal protein S8
chr10_+_70868633 1.36 ENSMUST00000058942.5
RIKEN cDNA 4930533K18 gene
chr5_-_120777628 1.36 ENSMUST00000044833.8
2'-5' oligoadenylate synthetase 3
chr17_-_32350569 1.35 ENSMUST00000050214.7
A kinase (PRKA) anchor protein 8-like
chr4_+_62525369 1.25 ENSMUST00000062145.1
RIKEN cDNA 4933430I17 gene
chr5_+_137745730 1.08 ENSMUST00000100540.3
TSC22 domain family, member 4
chr1_-_130423009 1.04 ENSMUST00000112488.2
decay accelerating factor 2
chr17_-_7827289 0.99 ENSMUST00000167580.1
fibronectin type III domain containing 1
chr16_-_36131156 0.96 ENSMUST00000161638.1
cystatin A
chr12_-_54695885 0.90 ENSMUST00000067272.8
E2F-associated phosphoprotein
chr6_-_56923927 0.90 ENSMUST00000031793.5
5'-nucleotidase, cytosolic III
chr5_-_5663263 0.89 ENSMUST00000148193.1
RIKEN cDNA A330021E22 gene
chr2_+_151996505 0.81 ENSMUST00000109859.2
solute carrier protein family 52, member 3
chr9_+_57940104 0.80 ENSMUST00000043059.7
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr4_-_41314877 0.77 ENSMUST00000030145.8
DDB1 and CUL4 associated factor 12
chr17_+_23679363 0.71 ENSMUST00000024699.2
claudin 6
chr10_+_75212065 0.67 ENSMUST00000105421.2
sperm antigen with calponin homology and coiled-coil domains 1-like
chr2_+_151572606 0.66 ENSMUST00000028950.8
syndecan binding protein (syntenin) 2
chr11_-_78751656 0.65 ENSMUST00000059468.4
family with sequence similarity 58, member B
chr9_+_59291565 0.64 ENSMUST00000026266.7
ADP-dependent glucokinase
chrX_+_20617503 0.55 ENSMUST00000115375.1
RNA binding motif protein 10
chr7_+_27486910 0.52 ENSMUST00000008528.7
SERTA domain containing 1
chr5_+_100196611 0.51 ENSMUST00000066813.1
predicted gene 9932
chrX_+_163909132 0.49 ENSMUST00000033734.7
adaptor-related protein complex 1, sigma 2 subunit
chr3_-_146521396 0.49 ENSMUST00000029838.6
ribosome production factor 1 homolog (S. cerevisiae)
chr11_+_49203465 0.46 ENSMUST00000150284.1
zinc finger protein 62
chr9_-_117252450 0.46 ENSMUST00000111773.3
RNA binding motif, single stranded interacting protein
chr15_+_79075209 0.42 ENSMUST00000040518.4
eukaryotic translation initiation factor 3, subunit L
chr3_+_76075583 0.39 ENSMUST00000160261.1
follistatin-like 5
chr15_+_51877742 0.38 ENSMUST00000136129.1
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr8_-_84104773 0.38 ENSMUST00000041367.7
DDB1 and CUL4 associated factor 15
chr4_-_62525036 0.35 ENSMUST00000030091.3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr2_-_129371131 0.31 ENSMUST00000028881.7
interleukin 1 beta
chr8_+_11713259 0.31 ENSMUST00000134409.1
RIKEN cDNA 1700128E19 gene
chr8_+_95534078 0.30 ENSMUST00000041569.3
coiled-coil domain containing 113
chr11_-_4440745 0.29 ENSMUST00000109948.1
HORMA domain containing 2
chr9_-_96478596 0.27 ENSMUST00000071301.4
ring finger protein 7
chr8_-_105979413 0.26 ENSMUST00000034371.7
dipeptidase 3
chr9_-_96478660 0.26 ENSMUST00000057500.4
ring finger protein 7
chr9_-_109702700 0.26 ENSMUST00000098359.3
F-box and WD-40 domain protein 18
chr9_-_109746089 0.24 ENSMUST00000071917.3
F-box and WD-40 domain protein 26
chr12_-_54695829 0.22 ENSMUST00000162106.1
E2F-associated phosphoprotein
chr1_+_190928822 0.16 ENSMUST00000135364.1
angel homolog 2 (Drosophila)
chr15_+_51877429 0.15 ENSMUST00000137116.2
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr9_-_109449140 0.13 ENSMUST00000084984.6
F-box and WD-40 domain protein 16
chr11_+_49203285 0.11 ENSMUST00000109198.1
zinc finger protein 62
chr19_-_5610038 0.11 ENSMUST00000113641.2
K(lysine) acetyltransferase 5
chr1_+_60409612 0.09 ENSMUST00000052332.8
abl-interactor 2
chr9_-_109626059 0.07 ENSMUST00000073962.6
F-box and WD-40 domain protein 24
chr14_-_52279238 0.07 ENSMUST00000167116.1
RAB2B, member RAS oncogene family
chr9_-_109568262 0.03 ENSMUST00000056745.6
F-box and WD-40 domain protein 15
chr2_-_132145057 0.02 ENSMUST00000028815.8
solute carrier family 23 (nucleobase transporters), member 2
chr2_+_83644435 0.01 ENSMUST00000081591.6
zinc finger CCCH-type containing 15

Network of associatons between targets according to the STRING database.

First level regulatory network of Mga

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 14.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.4 5.4 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
1.3 11.9 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
1.0 3.1 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.0 5.2 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.7 2.9 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.7 2.0 GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.6 1.7 GO:0003127 detection of nodal flow(GO:0003127) detection of endogenous stimulus(GO:0009726)
0.5 5.2 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.5 2.0 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.5 3.4 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.4 4.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.3 3.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.3 1.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.3 1.5 GO:0080154 regulation of fertilization(GO:0080154)
0.2 2.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 0.8 GO:0032218 riboflavin transport(GO:0032218)
0.2 1.4 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.1 1.3 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.1 1.4 GO:0098703 parathyroid hormone secretion(GO:0035898) calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 2.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 1.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.5 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.3 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.6 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1 0.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 1.0 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 4.6 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 1.9 GO:0050832 defense response to fungus(GO:0050832)
0.1 0.7 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.9 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 10.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 3.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.5 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 2.4 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 1.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.0 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 1.6 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.5 GO:0007569 cell aging(GO:0007569)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 6.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 1.5 GO:0002081 outer acrosomal membrane(GO:0002081)
0.2 3.0 GO:0005652 nuclear lamina(GO:0005652)
0.2 11.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 4.2 GO:0097440 apical dendrite(GO:0097440)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 11.6 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.7 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 14.7 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
1.0 3.1 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.7 2.0 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.5 5.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.4 2.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 3.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 0.8 GO:0032217 riboflavin transporter activity(GO:0032217)
0.2 2.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 10.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.5 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 1.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 4.2 GO:0045182 translation regulator activity(GO:0045182)
0.1 3.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.6 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.1 0.5 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.5 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 1.6 GO:0015026 coreceptor activity(GO:0015026)
0.1 11.9 GO:0008201 heparin binding(GO:0008201)
0.1 2.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.7 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 2.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 6.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.2 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.7 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 11.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.9 PID IL27 PATHWAY IL27-mediated signaling events
0.1 4.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.6 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 3.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.4 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 14.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 5.2 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 3.4 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 3.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 0.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 5.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions