ISMARA results: Klf1

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GSE58827: Dynamics of the Mouse Liver

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Results for Klf1

Z-value: 2.56

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Transcription factors associated with Klf1

Gene Symbol	Gene ID	Gene Info
Klf1 Ensembl NCBI MGI UniProt	ENSMUSG00000054191.7	Kruppel-like factor 1 (erythroid)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf1	mm10_v2_chr8_+_84901928_84901992	0.91	1.9e-14	Click!

Activity profile of Klf1 motif

Sorted Z-values of Klf1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_109849440 Show fit	24.44	ENSMUST00000112022.2	Camp Ensembl NCBI MGI UniProt Show fit	cathelicidin antimicrobial peptide
chr7_-_142578139 Show fit	24.05	ENSMUST00000136359.1	H19 Ensembl NCBI MGI UniProt Show fit	H19 fetal liver mRNA
chr14_+_80000292 Show fit	19.66	ENSMUST00000088735.3	Olfm4 Ensembl NCBI MGI UniProt Show fit	olfactomedin 4
chr7_-_142656018 Show fit	17.80	ENSMUST00000178921.1	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr11_+_11684967 Show fit	17.66	ENSMUST00000126058.1 ENSMUST00000141436.1	Ikzf1 Ensembl NCBI MGI UniProt Show fit	IKAROS family zinc finger 1
chr8_+_22974844 Show fit	15.70	ENSMUST00000110688.2 ENSMUST00000121802.2	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr9_+_111019284 Show fit	15.08	ENSMUST00000035077.3	Ltf Ensembl NCBI MGI UniProt Show fit	lactotransferrin
chr17_-_26201328 Show fit	14.56	ENSMUST00000025019.2	Arhgdig Ensembl NCBI MGI UniProt Show fit	Rho GDP dissociation inhibitor (GDI) gamma
chr12_-_4841583 Show fit	14.29	ENSMUST00000020964.5	Fkbp1b Ensembl NCBI MGI UniProt Show fit	FK506 binding protein 1b
chr6_+_86078070 Show fit	13.22	ENSMUST00000032069.5	Add2 Ensembl NCBI MGI UniProt Show fit	adducin 2 (beta)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	48.3	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.7	33.0	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
2.5	32.2	GO:2000653	regulation of genetic imprinting(GO:2000653)
3.0	29.9	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.3	27.6	GO:0001578	microtubule bundle formation(GO:0001578)
2.9	26.4	GO:0002432	granuloma formation(GO:0002432)
1.5	24.9	GO:0051873	disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
2.9	23.2	GO:0015671	oxygen transport(GO:0015671)
2.8	22.5	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1	20.5	GO:1990823	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Showing 1 to 10 of 647 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	42.2	GO:0042581	specific granule(GO:0042581)
5.2	41.7	GO:0005833	hemoglobin complex(GO:0005833)
0.5	36.1	GO:0005844	polysome(GO:0005844)
0.2	26.2	GO:0017053	transcriptional repressor complex(GO:0017053)
0.4	25.6	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
2.5	25.4	GO:0008290	F-actin capping protein complex(GO:0008290)
2.2	24.1	GO:0033093	Weibel-Palade body(GO:0033093)
5.9	23.6	GO:0070442	integrin alphaIIb-beta3 complex(GO:0070442)
1.7	23.1	GO:0090543	Flemming body(GO:0090543)
1.4	21.8	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)

Showing 1 to 10 of 236 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	49.0	GO:0051015	actin filament binding(GO:0051015)
1.1	40.0	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.7	32.5	GO:0003785	actin monomer binding(GO:0003785)
0.5	30.8	GO:0030507	spectrin binding(GO:0030507)
3.1	24.5	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
6.1	24.2	GO:0031721	hemoglobin alpha binding(GO:0031721)
0.6	21.3	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.4	20.1	GO:0070888	E-box binding(GO:0070888)
1.6	17.7	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
1.7	17.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)

Showing 1 to 10 of 412 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	35.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	28.7	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.4	24.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	23.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
2.6	20.6	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	18.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.0	18.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.4	18.0	PID RAS PATHWAY	Regulation of Ras family activation
0.3	17.4	PID PLK1 PATHWAY	PLK1 signaling events
0.3	15.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 94 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	37.2	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.6	25.3	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.5	25.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	22.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	21.6	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	21.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	20.9	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.4	18.9	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.4	18.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	13.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 141 entries

Results for Klf1

Z-value: 2.56

Motif logo

Transcription factors associated with Klf1

Activity-expression correlation:

Activity profile of Klf1 motif

Sorted Z-values of Klf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: