GSE58827: Dynamics of the Mouse Liver


Results for Irf3

Z-value: 1.10

Motif logo

Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
ENSMUSG00000003184.8 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_77411034 10.88 ENSMUST00000089452.5
apolipoprotein L 9a
chr15_+_77729091 10.51 ENSMUST00000109775.2
apolipoprotein L 9b
chr5_-_120812484 5.30 ENSMUST00000125547.1
2'-5' oligoadenylate synthetase 1C
chr11_-_49064202 4.95 ENSMUST00000046745.6
T cell specific GTPase 2
chr2_-_173218879 4.58 ENSMUST00000109116.2
Z-DNA binding protein 1
chr11_-_48992226 4.37 ENSMUST00000059930.2
predicted gene 12185
T cell specific GTPase 1
chr5_-_120812506 4.10 ENSMUST00000117193.1
2'-5' oligoadenylate synthetase 1C
chr8_-_71537402 3.83 ENSMUST00000051672.7
bone marrow stromal cell antigen 2
chr19_+_34583528 3.67 ENSMUST00000102825.3
interferon-induced protein with tetratricopeptide repeats 3
chr3_+_142560052 3.61 ENSMUST00000106222.2
guanylate binding protein 3
chr3_+_142560108 3.46 ENSMUST00000128609.1
guanylate binding protein 3
chr3_+_142560351 3.13 ENSMUST00000106221.1
guanylate binding protein 3
chr11_-_100704217 2.49 ENSMUST00000017974.6
DEXH (Asp-Glu-X-His) box polypeptide 58
chr3_+_142530329 2.44 ENSMUST00000171263.1
guanylate binding protein 7
chr17_+_34187545 2.39 ENSMUST00000170086.1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_-_141266415 2.36 ENSMUST00000106023.1
interferon regulatory factor 7
chr17_+_34187789 2.35 ENSMUST00000041633.8
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_+_122147680 2.30 ENSMUST00000102476.4
beta-2 microglobulin
chr16_-_35871544 2.30 ENSMUST00000042665.8
poly (ADP-ribose) polymerase family, member 14
chr6_-_23839137 2.28 ENSMUST00000166458.2
Ca2+-dependent activator protein for secretion 2
chr11_+_72301613 2.13 ENSMUST00000151440.1
XIAP associated factor 1
chr5_-_120887582 2.10 ENSMUST00000086368.5
2'-5' oligoadenylate synthetase 1G
chr3_-_151749877 2.07 ENSMUST00000029671.7
interferon-induced protein 44
chr11_-_48871344 2.06 ENSMUST00000049519.3
immunity-related GTPase family M member 1
chr11_+_58199556 2.05 ENSMUST00000035266.4
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr2_-_126933229 1.97 ENSMUST00000028844.4
signal peptide peptidase like 2A
chr11_+_58215028 1.97 ENSMUST00000108836.1
immunity-related GTPase family M member 2
chr16_+_23609895 1.92 ENSMUST00000038423.5
receptor transporter protein 4
chr11_-_48871408 1.81 ENSMUST00000097271.2
immunity-related GTPase family M member 1
chr15_-_77533312 1.76 ENSMUST00000062562.5
apolipoprotein L 7c
chr17_-_34187219 1.71 ENSMUST00000173831.1
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr5_+_123252087 1.62 ENSMUST00000121964.1
WD repeat domain 66
chr3_+_81932601 1.61 ENSMUST00000029649.2
cathepsin O
chr2_+_38998302 1.60 ENSMUST00000112872.1
WD repeat domain 38
chr2_-_62646146 1.57 ENSMUST00000112459.3
interferon induced with helicase C domain 1
chr7_-_104315455 1.45 ENSMUST00000106837.1
tripartite motif-containing 12A
chr5_+_114896936 1.39 ENSMUST00000031542.9
2'-5' oligoadenylate synthetase-like 2
chr11_-_83530505 1.36 ENSMUST00000035938.2
chemokine (C-C motif) ligand 5
chr6_-_39118211 1.36 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr15_+_32920723 1.31 ENSMUST00000022871.5
syndecan 2
chr13_+_40859768 1.28 ENSMUST00000110191.2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr10_+_128270546 1.26 ENSMUST00000105238.3
signal transducer and activator of transcription 2
chr5_-_120907510 1.24 ENSMUST00000080322.7
2'-5' oligoadenylate synthetase 1A
chr3_-_69127098 1.18 ENSMUST00000029353.2
karyopherin (importin) alpha 4
chr4_-_156200818 1.08 ENSMUST00000085425.4
ISG15 ubiquitin-like modifier
chr19_+_6046576 1.06 ENSMUST00000138532.1
synovial apoptosis inhibitor 1, synoviolin
chr13_-_23710714 1.06 ENSMUST00000091707.6
chr9_+_20868628 1.02 ENSMUST00000043911.7
RIKEN cDNA A230050P20 gene
chr16_+_35938470 0.93 ENSMUST00000114878.1
poly (ADP-ribose) polymerase family, member 9
chr13_+_74639866 0.91 ENSMUST00000169114.1
endoplasmic reticulum aminopeptidase 1
chr7_+_104244449 0.75 ENSMUST00000106849.2
tripartite motif-containing 34A
chr2_-_173276144 0.72 ENSMUST00000139306.1
prostate transmembrane protein, androgen induced 1
chr16_-_38341812 0.67 ENSMUST00000114740.2
MYCBP-associated, testis expressed 1
chr16_+_35938972 0.64 ENSMUST00000023622.6
poly (ADP-ribose) polymerase family, member 9
chr4_-_40239779 0.64 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_-_15922361 0.63 ENSMUST00000044355.7
selenoprotein W, muscle 1
chr10_+_83543941 0.62 ENSMUST00000038388.5
RIKEN cDNA A230046K03 gene
chr7_+_104300230 0.59 ENSMUST00000106847.1
tripartite motif-containing 34B
chr2_-_167062981 0.54 ENSMUST00000048988.7
zinc finger, NFX1-type containing 1
chr7_+_104244465 0.54 ENSMUST00000106848.1
tripartite motif-containing 34A
chr7_-_126594941 0.49 ENSMUST00000058429.5
interleukin 27
chr7_-_104353328 0.49 ENSMUST00000130139.1
tripartite motif-containing 12C
chr17_+_23660477 0.48 ENSMUST00000062967.8
coiled-coil domain containing 64B
chr6_+_129512538 0.46 ENSMUST00000032263.5
transmembrane protein 52B
chr9_-_22130598 0.45 ENSMUST00000115315.2
acid phosphatase 5, tartrate resistant
chr14_-_55591077 0.45 ENSMUST00000161807.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_-_125231772 0.44 ENSMUST00000043422.7
TAP binding protein-like
chr7_+_103415072 0.42 ENSMUST00000106892.1
ubiquitin specific peptidase 17-like C
chrX_+_53434918 0.40 ENSMUST00000074232.6
embryonic testis differentiation
chr11_+_83852920 0.40 ENSMUST00000108113.1
HNF1 homeobox B
chr4_+_44012638 0.37 ENSMUST00000107847.3
clathrin, light polypeptide (Lca)
chr6_-_54972603 0.36 ENSMUST00000060655.8
nucleotide-binding oligomerization domain containing 1
chr2_+_180589245 0.35 ENSMUST00000029087.3
opioid growth factor receptor
chr7_+_104244496 0.34 ENSMUST00000106854.1
tripartite motif-containing 34A
chr4_+_44012661 0.31 ENSMUST00000107849.3
clathrin, light polypeptide (Lca)
chr14_+_55578123 0.30 ENSMUST00000174484.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr9_-_14718381 0.26 ENSMUST00000115643.1
piwi-like RNA-mediated gene silencing 4
chr11_+_109362771 0.25 ENSMUST00000020930.7
guanine nucleotide binding protein, alpha 13
chr11_+_119393060 0.24 ENSMUST00000131035.2
ring finger protein 213
chr1_-_75317536 0.22 ENSMUST00000066668.7
aspartyl aminopeptidase
chr14_+_55578360 0.22 ENSMUST00000174259.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr6_+_34863130 0.19 ENSMUST00000074949.3
transmembrane protein 140
chr1_-_75316998 0.18 ENSMUST00000113605.3
aspartyl aminopeptidase
chr7_+_103416696 0.18 ENSMUST00000079348.3
ubiquitin specific peptidase 17-like C
chr15_+_39112868 0.16 ENSMUST00000022909.8
DDB1 and CUL4 associated factor 13
chr16_-_35939082 0.15 ENSMUST00000081933.7
deltex 3-like (Drosophila)
chr10_-_81496313 0.14 ENSMUST00000118498.1
nicalin homolog (zebrafish)
chr18_+_23989632 0.14 ENSMUST00000074941.7
zinc finger protein 35
chr8_+_61928081 0.13 ENSMUST00000154398.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr15_-_39112642 0.13 ENSMUST00000022908.8
solute carrier family 25, member 32
chr2_+_93187574 0.13 ENSMUST00000090554.4
transformation related protein 53 inducible protein 11
chr16_-_10785525 0.11 ENSMUST00000038099.4
suppressor of cytokine signaling 1
chr16_-_19706365 0.10 ENSMUST00000081880.5
lysosomal-associated membrane protein 3
chr10_-_81496329 0.09 ENSMUST00000020463.7
nicalin homolog (zebrafish)
chr1_-_85109449 0.08 ENSMUST00000161724.1
RIKEN cDNA A530032D15Rik gene
chr6_-_38354243 0.08 ENSMUST00000114900.1
zinc finger CCCH type, antiviral 1
chr1_-_85109846 0.03 ENSMUST00000161675.1
RIKEN cDNA A530032D15Rik gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 2.3 GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
1.0 4.0 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.9 4.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.9 2.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.8 2.4 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.8 1.5 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.6 33.0 GO:0035456 response to interferon-beta(GO:0035456)
0.6 2.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.5 1.6 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.5 4.6 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.3 1.4 GO:0035697 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) CD8-positive, alpha-beta T cell extravasation(GO:0035697) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.3 2.3 GO:1990504 dense core granule exocytosis(GO:1990504)
0.2 2.0 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 1.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 0.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 1.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 2.4 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.1 1.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.4 GO:1901146 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.1 1.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.3 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.3 GO:0035546 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.0 0.5 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.0 1.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.4 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.0 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 16.7 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.6 4.7 GO:0042825 TAP complex(GO:0042825)
0.3 1.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 2.0 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.3 3.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 3.9 GO:0044754 autolysosome(GO:0044754)
0.2 0.7 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.2 1.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.5 GO:1990462 omegasome(GO:1990462)
0.0 0.3 GO:0071547 piP-body(GO:0071547)
0.0 0.1 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 2.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 10.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0003692 left-handed Z-DNA binding(GO:0003692)
1.3 14.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.9 4.7 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.5 1.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.5 1.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.4 4.0 GO:0051434 BH3 domain binding(GO:0051434)
0.3 1.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.3 3.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 2.0 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 4.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 1.7 GO:0070628 proteasome binding(GO:0070628)
0.1 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 23.4 GO:0003924 GTPase activity(GO:0003924)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0034584 piRNA binding(GO:0034584)
0.0 0.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.5 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 1.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 4.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 PID ARF 3PATHWAY Arf1 pathway
0.0 2.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 5.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 4.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 4.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 3.6 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 2.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 2.6 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes