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GSE58827: Dynamics of the Mouse Liver
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Results for Hoxb7
Z-value: 1.96
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Transcription factors associated with Hoxb7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb7 | mm10_v2_chr11_+_96286623_96286653 | -0.01 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_75270073 Show fit | 5.06 |
ENSMUST00000039047.4
|
serine (or cysteine) peptidase inhibitor, clade I, member 2 |
|
| chr5_-_62765618 Show fit | 4.62 |
ENSMUST00000159470.1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chr11_-_30198232 Show fit | 4.15 |
ENSMUST00000102838.3
|
spectrin beta, non-erythrocytic 1 |
|
| chr4_+_108719649 Show fit | 4.10 |
ENSMUST00000178992.1
|
RIKEN cDNA 3110021N24 gene |
|
| chr18_+_20247340 Show fit | 4.05 |
ENSMUST00000054128.6
|
desmoglein 1 gamma |
|
| chr8_-_36953139 Show fit | 4.04 |
ENSMUST00000179501.1
|
deleted in liver cancer 1 |
|
| chr1_-_150466165 Show fit | 3.92 |
ENSMUST00000162367.1
ENSMUST00000161611.1 ENSMUST00000161320.1 ENSMUST00000159035.1 |
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) |
|
| chr3_-_113532288 Show fit | 3.61 |
ENSMUST00000132353.1
|
amylase 2a1 |
|
| chr8_-_8639363 Show fit | 3.54 |
ENSMUST00000152698.1
|
ephrin B2 |
|
| chr2_-_62483637 Show fit | 3.54 |
ENSMUST00000136686.1
ENSMUST00000102733.3 |
glucagon |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 11.4 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 8.8 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 8.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.5 | 8.2 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.6 | 7.7 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.9 | 7.4 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.7 | 7.2 | GO:1900827 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.9 | 6.8 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.8 | 6.8 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.8 | 6.5 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 11.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 9.5 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 8.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 8.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 8.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 7.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 7.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.3 | 7.1 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 6.7 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 9.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 9.3 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 8.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.5 | 8.0 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.1 | 8.0 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.3 | 7.8 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 7.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 1.1 | 7.4 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.3 | 6.7 | GO:0045295 | gamma-catenin binding(GO:0045295) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 15.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 13.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 12.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 8.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 7.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 6.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 5.4 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 12.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 9.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 9.9 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.3 | 8.0 | REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION | Genes involved in Incretin Synthesis, Secretion, and Inactivation |
| 0.2 | 6.5 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.4 | 5.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 5.0 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 4.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |