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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxa1

Z-value: 0.43

Motif logo

Transcription factors associated with Hoxa1

Gene Symbol Gene ID Gene Info
ENSMUSG00000029844.9 homeobox A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa1mm10_v2_chr6_-_52158292_521583240.335.1e-02Click!

Activity profile of Hoxa1 motif

Sorted Z-values of Hoxa1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_12340723 1.97 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
actinin alpha 2
chr11_-_43601540 1.96 ENSMUST00000020672.4
fatty acid binding protein 6, ileal (gastrotropin)
chr17_+_25298389 1.75 ENSMUST00000037453.2
protease, serine, 34
chr15_-_95528702 1.70 ENSMUST00000166170.1
NEL-like 2
chr11_+_24080664 0.99 ENSMUST00000118955.1
B cell CLL/lymphoma 11A (zinc finger protein)
chr14_-_69284982 0.96 ENSMUST00000183882.1
ENSMUST00000037064.4
solute carrier family 25, member 37
chr10_+_88885992 0.75 ENSMUST00000020255.6
solute carrier family 5 (iodide transporter), member 8
chrX_+_56454871 0.74 ENSMUST00000039374.2
ENSMUST00000101553.2
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_-_119053339 0.70 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
GLI-Kruppel family member GLI2
chr3_+_114030532 0.70 ENSMUST00000123619.1
ENSMUST00000092155.5
collagen, type XI, alpha 1
chr7_-_30534180 0.66 ENSMUST00000044338.4
Rho GTPase activating protein 33
chr9_+_65890237 0.65 ENSMUST00000045802.6
RIKEN cDNA 2810417H13 gene
chr4_-_143299498 0.64 ENSMUST00000030317.7
podoplanin
chr14_-_69503316 0.62 ENSMUST00000179116.2
predicted gene, 21464
chr7_+_73391160 0.62 ENSMUST00000128471.1
RGM domain family, member A
chr1_-_45503282 0.59 ENSMUST00000086430.4
collagen, type V, alpha 2
chr2_-_131042682 0.58 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
glial cell line derived neurotrophic factor family receptor alpha 4
chr8_-_8639363 0.56 ENSMUST00000152698.1
ephrin B2
chr18_-_13972617 0.52 ENSMUST00000025288.7
zinc finger protein 521
chr9_-_21312255 0.52 ENSMUST00000115433.3
ENSMUST00000003397.7
adaptor protein complex AP-1, mu 2 subunit
chr15_+_102990576 0.50 ENSMUST00000001703.6
homeobox C8
chr2_+_165595009 0.46 ENSMUST00000088132.6
eyes absent 2 homolog (Drosophila)
chr10_+_14523062 0.45 ENSMUST00000096020.5
predicted gene 10335
chr19_-_41743665 0.42 ENSMUST00000025993.3
slit homolog 1 (Drosophila)
chr13_+_72628802 0.41 ENSMUST00000074372.4
Iroquois related homeobox 2 (Drosophila)
chr6_+_142298419 0.40 ENSMUST00000041993.2
islet amyloid polypeptide
chr7_+_144838590 0.37 ENSMUST00000105898.1
fibroblast growth factor 3
chr9_+_110344185 0.35 ENSMUST00000142100.1
SREBF chaperone
chr1_-_119053619 0.34 ENSMUST00000062483.8
GLI-Kruppel family member GLI2
chr2_+_32587057 0.32 ENSMUST00000102818.4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr15_+_82252397 0.32 ENSMUST00000136948.1
RIKEN cDNA 1500009C09 gene
chr2_-_160619971 0.32 ENSMUST00000109473.1
predicted gene 14221
chr5_+_27261916 0.32 ENSMUST00000101471.3
dipeptidylpeptidase 6
chr4_-_143299463 0.31 ENSMUST00000119654.1
podoplanin
chr2_-_131043088 0.31 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
glial cell line derived neurotrophic factor family receptor alpha 4
chr17_-_51826562 0.30 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
special AT-rich sequence binding protein 1
chr13_+_31806627 0.30 ENSMUST00000062292.2
forkhead box C1
chr2_+_163225363 0.30 ENSMUST00000099110.3
ENSMUST00000165937.1
TOX high mobility group box family member 2
chrX_-_150813637 0.30 ENSMUST00000112700.1
melanoma antigen, family D, 2
chr9_-_96862903 0.28 ENSMUST00000121077.1
ENSMUST00000124923.1
acid phosphatase-like 2
chrX_-_150812932 0.27 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
melanoma antigen, family D, 2
chr5_-_145201829 0.26 ENSMUST00000162220.1
ENSMUST00000031632.8
zinc finger with KRAB and SCAN domains 14
chr19_+_46396885 0.26 ENSMUST00000039922.6
ENSMUST00000111867.2
ENSMUST00000120778.1
suppressor of fused homolog (Drosophila)
chr9_+_58129321 0.25 ENSMUST00000034880.3
stimulated by retinoic acid gene 6
chr9_+_58129062 0.24 ENSMUST00000085677.2
stimulated by retinoic acid gene 6
chr10_+_79988584 0.24 ENSMUST00000004784.4
ENSMUST00000105374.1
calponin 2
chr3_+_55782500 0.21 ENSMUST00000075422.4
mab-21-like 1 (C. elegans)
chr10_+_94576254 0.21 ENSMUST00000117929.1
transmembrane and coiled coil domains 3
chr4_+_119814495 0.21 ENSMUST00000106307.2
human immunodeficiency virus type I enhancer binding protein 3
chr3_+_58526303 0.20 ENSMUST00000138848.1
eukaryotic translation initiation factor 2A
chr2_-_152951688 0.20 ENSMUST00000109811.3
dual specificity phosphatase-like 15
chr14_+_66344369 0.19 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
stathmin-like 4
chr9_-_31464238 0.19 ENSMUST00000048050.7
transmembrane protein 45b
chr4_+_101507947 0.18 ENSMUST00000149047.1
ENSMUST00000106929.3
DnaJ (Hsp40) homolog, subfamily C, member 6
chr4_+_138775735 0.17 ENSMUST00000030528.2
phospholipase A2, group IID
chr3_+_58525821 0.17 ENSMUST00000029387.8
eukaryotic translation initiation factor 2A
chr3_+_68572245 0.17 ENSMUST00000170788.2
schwannomin interacting protein 1
chr4_-_145315143 0.17 ENSMUST00000030339.6
tumor necrosis factor receptor superfamily, member 8
chr5_+_137030275 0.17 ENSMUST00000041543.8
VGF nerve growth factor inducible
chr2_+_90885860 0.16 ENSMUST00000111466.2
C1q and tumor necrosis factor related protein 4
chr1_-_180813534 0.15 ENSMUST00000159789.1
ENSMUST00000081026.4
H3 histone, family 3A
chr1_+_153891646 0.15 ENSMUST00000050660.4
transmembrane epididymal protein 1
chrX_-_75578188 0.15 ENSMUST00000033545.5
RAB39B, member RAS oncogene family
chr14_+_66344296 0.15 ENSMUST00000152093.1
ENSMUST00000074523.6
stathmin-like 4
chr17_-_28622419 0.15 ENSMUST00000114767.1
serine/arginine-rich protein specific kinase 1
chr11_+_58665561 0.15 ENSMUST00000072030.3
olfactory receptor 322
chr16_+_36308045 0.15 ENSMUST00000114851.1
predicted gene 4758
chr1_-_180813591 0.14 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3 histone, family 3A
chr1_+_89454769 0.14 ENSMUST00000027521.8
ENSMUST00000074945.5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr2_+_65845767 0.13 ENSMUST00000122912.1
cysteine-serine-rich nuclear protein 3
chr17_+_78491549 0.12 ENSMUST00000079363.4
predicted pseudogene 10093
chr4_+_101507855 0.12 ENSMUST00000038207.5
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_-_52012476 0.11 ENSMUST00000078214.5
src family associated phosphoprotein 2
chr14_-_103844173 0.11 ENSMUST00000022718.3
endothelin receptor type B
chr15_+_98167806 0.11 ENSMUST00000031914.4
expressed sequence AI836003
chr11_-_5898771 0.11 ENSMUST00000102921.3
myosin, light polypeptide 7, regulatory
chr10_-_10429839 0.11 ENSMUST00000045328.7
androglobin
chr1_+_153665274 0.10 ENSMUST00000152114.1
ENSMUST00000111812.1
regulator of G-protein signaling 8
chr6_+_49319274 0.10 ENSMUST00000055559.7
ENSMUST00000114491.1
coiled-coil domain containing 126
chr6_+_116506516 0.10 ENSMUST00000075756.2
olfactory receptor 212
chr13_+_99184733 0.10 ENSMUST00000056558.8
zinc finger protein 366
chr13_-_103764502 0.09 ENSMUST00000074616.5
splicing regulatory glutamine/lysine-rich protein 1
chr11_-_69549108 0.09 ENSMUST00000108659.1
dynein, axonemal, heavy chain 2
chr8_-_105484350 0.09 ENSMUST00000044286.5
zinc finger, DHHC domain containing 1
chr16_+_18877037 0.09 ENSMUST00000120532.1
ENSMUST00000004222.7
histone cell cycle regulation defective homolog A (S. cerevisiae)
chr9_-_4796218 0.09 ENSMUST00000027020.6
ENSMUST00000063508.7
ENSMUST00000163309.1
glutamate receptor, ionotropic, AMPA4 (alpha 4)
chr7_+_103979176 0.09 ENSMUST00000098185.1
olfactory receptor 635
chr2_+_36452587 0.09 ENSMUST00000072854.1
olfactory receptor 340
chr2_+_36230426 0.08 ENSMUST00000062069.5
prostaglandin-endoperoxide synthase 1
chr9_+_113930934 0.08 ENSMUST00000084885.5
ENSMUST00000009885.7
upstream binding protein 1
chr4_+_150997081 0.07 ENSMUST00000030803.1
urotensin 2
chr10_+_90071095 0.07 ENSMUST00000183109.1
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_+_70077375 0.06 ENSMUST00000035908.1
early growth response 3
chr11_+_96351632 0.06 ENSMUST00000100523.5
homeobox B2
chr2_-_26246707 0.06 ENSMUST00000166349.1
RIKEN cDNA C030048H21 gene
chr12_-_80260356 0.05 ENSMUST00000021554.8
actinin, alpha 1
chr3_+_138352378 0.05 ENSMUST00000090166.4
alcohol dehydrogenase 6B (class V)
chr5_-_107289561 0.05 ENSMUST00000031224.8
transforming growth factor, beta receptor III
chr15_-_78388757 0.05 ENSMUST00000169575.1
testis expressed 33
chr9_+_58129476 0.05 ENSMUST00000133287.1
stimulated by retinoic acid gene 6
chr10_+_81628540 0.04 ENSMUST00000123896.1
ankyrin repeat domain 24
chr12_+_53248677 0.04 ENSMUST00000101432.2
neuronal PAS domain protein 3
chr5_+_43515513 0.04 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1q and tumor necrosis factor related protein 7
chr15_+_74516196 0.04 ENSMUST00000042035.9
brain-specific angiogenesis inhibitor 1
chr17_-_28622479 0.04 ENSMUST00000130643.1
serine/arginine-rich protein specific kinase 1
chr2_+_152962485 0.04 ENSMUST00000099197.2
ENSMUST00000103155.3
tubulin tyrosine ligase-like family, member 9
chr11_-_65159890 0.03 ENSMUST00000020855.3
ENSMUST00000108696.1
RIKEN cDNA 1700086D15 gene
chr6_+_40442863 0.02 ENSMUST00000038907.8
ENSMUST00000141490.1
WEE1 homolog 2 (S. pombe)
chr7_+_140322602 0.02 ENSMUST00000078103.2
olfactory receptor 525
chr2_+_124610573 0.02 ENSMUST00000103239.3
ENSMUST00000103240.2
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr17_+_70522149 0.02 ENSMUST00000140728.1
discs, large (Drosophila) homolog-associated protein 1
chr9_-_20336094 0.02 ENSMUST00000086473.3
olfactory receptor 18
chr14_+_56575603 0.02 ENSMUST00000161553.1
poly (ADP-ribose) polymerase family, member 4
chr7_-_16917184 0.01 ENSMUST00000173139.1
calmodulin 3
chr4_-_11981265 0.01 ENSMUST00000098260.2
predicted gene 10604
chr4_-_108406676 0.01 ENSMUST00000184609.1
glutathione peroxidase 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.3 1.0 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.3 1.0 GO:0060032 notochord regression(GO:0060032)
0.2 1.0 GO:1904799 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.1 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.7 GO:0035989 tendon development(GO:0035989)
0.1 1.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.3 GO:1990869 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 0.4 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.3 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.6 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.5 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 0.3 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.4 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.4 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 0.4 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 2.0 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 0.3 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.4 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.6 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.1 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 1.0 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.3 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0035633 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.0 0.2 GO:0043084 penile erection(GO:0043084)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.0 GO:0097542 ciliary tip(GO:0097542)
0.1 0.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 2.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0051373 FATZ binding(GO:0051373)
0.3 0.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 2.0 GO:0032052 bile acid binding(GO:0032052)
0.1 1.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.0 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids