ISMARA results: Gtf2i

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GSE58827: Dynamics of the Mouse Liver

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Results for Gtf2i_Gtf2f1

Z-value: 0.95

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Transcription factors associated with Gtf2i_Gtf2f1

Gene Symbol	Gene ID	Gene Info
Gtf2i Ensembl NCBI MGI UniProt	ENSMUSG00000060261.9	general transcription factor II I
Gtf2f1 Ensembl NCBI MGI UniProt	ENSMUSG00000002658.9	general transcription factor IIF, polypeptide 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Gtf2i	mm10_v2_chr5_-_134314637_134314676	0.53	1.0e-03	Click!
Gtf2f1	mm10_v2_chr17_-_57011271_57011326	0.04	8.2e-01	Click!

Activity profile of Gtf2i_Gtf2f1 motif

Sorted Z-values of Gtf2i_Gtf2f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_70679016 Show fit	1.89	ENSMUST00000144537.1	Adam10 Ensembl NCBI MGI UniProt Show fit	a disintegrin and metallopeptidase domain 10
chr15_-_66948419 Show fit	1.82	ENSMUST00000167817.1	Ndrg1 Ensembl NCBI MGI UniProt Show fit	N-myc downstream regulated gene 1
chr14_+_54640952 Show fit	1.78	ENSMUST00000169818.2	Gm17606 Ensembl NCBI MGI UniProt Show fit	predicted gene, 17606
chr5_+_43672289 Show fit	1.69	ENSMUST00000156034.1	Cc2d2a Ensembl NCBI MGI UniProt Show fit	coiled-coil and C2 domain containing 2A
chrX_+_13071470 Show fit	1.44	ENSMUST00000169594.2	Usp9x Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 9, X chromosome
chr10_-_127620960 Show fit	1.43	ENSMUST00000121829.1	Lrp1 Ensembl NCBI MGI UniProt Show fit	low density lipoprotein receptor-related protein 1
chr17_+_26941420 Show fit	1.37	ENSMUST00000081285.3 ENSMUST00000177932.1	Syngap1 Ensembl NCBI MGI UniProt Show fit	synaptic Ras GTPase activating protein 1 homolog (rat)
chr16_-_74411776 Show fit	1.34	ENSMUST00000116586.2	Robo2 Ensembl NCBI MGI UniProt Show fit	roundabout homolog 2 (Drosophila)
chr10_-_127620922 Show fit	1.32	ENSMUST00000118455.1	Lrp1 Ensembl NCBI MGI UniProt Show fit	low density lipoprotein receptor-related protein 1
chr4_-_43558386 Show fit	1.30	ENSMUST00000130353.1	Tln1 Ensembl NCBI MGI UniProt Show fit	talin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Gtf2i_Gtf2f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.1	GO:0010107	potassium ion import(GO:0010107)
0.8	3.1	GO:1905167	positive regulation of lysosomal protein catabolic process(GO:1905167)
0.9	2.6	GO:0050925	negative regulation of negative chemotaxis(GO:0050925)
0.5	2.4	GO:0042117	monocyte activation(GO:0042117)
0.3	1.8	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.2	1.8	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.0	1.8	GO:0001578	microtubule bundle formation(GO:0001578)
0.2	1.7	GO:1902746	regulation of lens fiber cell differentiation(GO:1902746)
0.2	1.7	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.1	1.7	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)

Showing 1 to 10 of 577 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	4.5	GO:0014069	postsynaptic density(GO:0014069)
0.0	4.4	GO:0005923	bicellular tight junction(GO:0005923)
0.0	3.3	GO:0000118	histone deacetylase complex(GO:0000118)
0.2	2.4	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	2.4	GO:0016592	mediator complex(GO:0016592)
0.1	2.3	GO:0097470	ribbon synapse(GO:0097470)
0.0	2.1	GO:0000775	chromosome, centromeric region(GO:0000775)
0.0	2.0	GO:0055038	recycling endosome membrane(GO:0055038)
0.2	1.9	GO:0030478	actin cap(GO:0030478)

Showing 1 to 10 of 177 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	4.7	GO:0017124	SH3 domain binding(GO:0017124)
0.1	3.6	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	3.6	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
1.0	3.0	GO:0016964	alpha-2 macroglobulin receptor activity(GO:0016964)
0.2	2.4	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	2.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	2.3	GO:0042393	histone binding(GO:0042393)
0.2	1.9	GO:0030274	LIM domain binding(GO:0030274)
0.1	1.8	GO:0050693	LBD domain binding(GO:0050693)

Showing 1 to 10 of 289 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	3.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	3.3	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	3.0	PID PLK1 PATHWAY	PLK1 signaling events
0.0	2.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	2.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	2.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.1	2.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	1.6	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	1.6	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling

Showing 1 to 10 of 66 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	2.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	2.3	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	2.1	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	1.8	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	1.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	1.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	1.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo

Showing 1 to 10 of 84 entries

Results for Gtf2i_Gtf2f1

Z-value: 0.95

Motif logo

Transcription factors associated with Gtf2i_Gtf2f1

Activity-expression correlation:

Activity profile of Gtf2i_Gtf2f1 motif

Sorted Z-values of Gtf2i_Gtf2f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Gtf2i_Gtf2f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: