GSE58827: Dynamics of the Mouse Liver


Results for Foxl1

Z-value: 0.57

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Transcription factors associated with Foxl1

Gene Symbol Gene ID Gene Info
ENSMUSG00000097084.1 forkhead box L1
ENSMUSG00000043867.5 forkhead box L1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Foxl1 motif

Sorted Z-values of Foxl1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_40811089 5.07 ENSMUST00000024721.7
Rhesus blood group-associated A glycoprotein
chr4_-_99654983 4.19 ENSMUST00000136525.1
predicted gene 12688
chr10_+_79879614 4.02 ENSMUST00000006679.8
proteinase 3
chr13_+_23763660 2.83 ENSMUST00000055770.1
histone cluster 1, H1a
chr4_+_11191726 2.60 ENSMUST00000029866.9
cyclin E2
chr3_-_123034943 2.50 ENSMUST00000029761.7
myozenin 2
chr8_+_15057646 2.28 ENSMUST00000033842.3
myomesin 2
chr13_+_23575753 2.07 ENSMUST00000105105.1
histone cluster 1, H3d
chr10_+_88091070 2.05 ENSMUST00000048621.7
pro-melanin-concentrating hormone
chr9_+_121777607 1.48 ENSMUST00000098272.2
kelch-like 40
chr18_-_15151427 1.48 ENSMUST00000025992.6
potassium channel tetramerisation domain containing 1
chr11_+_31872100 1.43 ENSMUST00000020543.6
cytoplasmic polyadenylation element binding protein 4
chr9_+_71215779 1.21 ENSMUST00000034723.5
aldehyde dehydrogenase family 1, subfamily A2
chr13_-_23622502 1.14 ENSMUST00000062045.2
histone cluster 1, H1e
chr7_+_91090728 1.06 ENSMUST00000074273.3
discs, large homolog 2 (Drosophila)
chrX_+_133850980 1.06 ENSMUST00000033602.8
chr7_+_91090697 1.01 ENSMUST00000107196.2
discs, large homolog 2 (Drosophila)
chr12_+_69963452 0.97 ENSMUST00000110560.1
predicted gene 3086
chr2_-_59948155 0.94 ENSMUST00000153136.1
bromodomain adjacent to zinc finger domain, 2B
chr13_+_23555023 0.83 ENSMUST00000045301.6
histone cluster 1, H1d
chrX_+_112604274 0.81 ENSMUST00000071814.6
zinc finger protein 711
chr18_+_34409415 0.79 ENSMUST00000166156.1
polycystic kidney disease 2-like 2
chr13_+_23738804 0.72 ENSMUST00000040914.1
histone cluster 1, H1c
chr7_-_119479249 0.70 ENSMUST00000033263.4
chr1_+_66386968 0.68 ENSMUST00000145419.1
microtubule-associated protein 2
chr5_-_83355120 0.63 ENSMUST00000053543.4
trans-2,3-enoyl-CoA reductase-like
chr7_+_122289297 0.63 ENSMUST00000064989.5
protein kinase C, beta
chr6_-_142804390 0.58 ENSMUST00000111768.1
predicted gene 766
chr4_-_121017201 0.51 ENSMUST00000043200.7
small ArfGAP 2
chr5_+_33018816 0.37 ENSMUST00000019109.7
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr6_+_42286676 0.28 ENSMUST00000031894.6
chloride channel 1
chr15_+_43477213 0.26 ENSMUST00000022962.6
ER membrane protein complex subunit 2
chrX_-_94123087 0.25 ENSMUST00000113925.1
zinc finger protein X-linked
chr7_+_84853573 0.25 ENSMUST00000078172.4
olfactory receptor 291
chr5_-_83354946 0.25 ENSMUST00000146669.1
trans-2,3-enoyl-CoA reductase-like
chr15_-_11905609 0.20 ENSMUST00000066529.3
natriuretic peptide receptor 3
chrX_+_18162575 0.15 ENSMUST00000044484.6
lysine (K)-specific demethylase 6A
chr2_+_18055203 0.14 ENSMUST00000028076.8
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr6_+_42286709 0.14 ENSMUST00000163936.1
chloride channel 1
chr10_+_56377300 0.08 ENSMUST00000068581.7
gap junction protein, alpha 1
chr5_-_87699414 0.06 ENSMUST00000082370.5
casein beta
chr1_-_144249134 0.05 ENSMUST00000172388.1
regulator of G-protein signaling 1
chr6_-_14755250 0.03 ENSMUST00000045096.4
protein phosphatase 1, regulatory (inhibitor) subunit 3A

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 4.0 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.7 2.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.3 2.7 GO:0016584 nucleosome positioning(GO:0016584)
0.3 1.5 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.2 0.7 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.2 1.2 GO:0042905 ureter maturation(GO:0035799) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 2.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 1.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 2.1 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 0.6 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.4 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.1 2.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.9 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.4 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.5 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.1 GO:0010643 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 2.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 7.6 GO:0000786 nucleosome(GO:0000786)
0.1 2.3 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.5 GO:0031672 A band(GO:0031672)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 2.5 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0051373 FATZ binding(GO:0051373)
0.3 5.1 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.2 1.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 1.1 GO:0032564 dATP binding(GO:0032564)
0.1 2.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.6 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.7 GO:0019864 IgG binding(GO:0019864)
0.1 2.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 2.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.9 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 2.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 3.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 5.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors