GSE58827: Dynamics of the Mouse Liver


Results for Cebpd

Z-value: 1.27

Motif logo

Transcription factors associated with Cebpd

Gene Symbol Gene ID Gene Info
ENSMUSG00000071637.4 CCAAT/enhancer binding protein (C/EBP), delta

Activity profile of Cebpd motif

Sorted Z-values of Cebpd motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_46751832 20.13 ENSMUST00000075982.2
serum amyloid A 2
chr4_+_63344548 18.37 ENSMUST00000030044.2
orosomucoid 1
chr4_+_63362443 17.91 ENSMUST00000075341.3
orosomucoid 2
chr9_-_48605147 15.45 ENSMUST00000034808.5
nicotinamide N-methyltransferase
chr17_+_36942910 12.07 ENSMUST00000040498.5
ring finger protein 39
chr17_+_36943025 10.38 ENSMUST00000173072.1
ring finger protein 39
chrX_+_59999436 8.89 ENSMUST00000033477.4
coagulation factor IX
chr17_-_56121946 8.26 ENSMUST00000041357.7
leucine-rich alpha-2-glycoprotein 1
chr5_+_114146525 6.13 ENSMUST00000102582.1
acetyl-Coenzyme A carboxylase beta
chr11_-_75422524 5.92 ENSMUST00000125982.1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr10_+_93488766 5.78 ENSMUST00000129421.1
histidine ammonia lyase
chr6_-_124542281 5.72 ENSMUST00000159463.1
complement component 1, s subcomponent
chr11_-_75422586 5.29 ENSMUST00000138661.1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr6_+_17463749 5.06 ENSMUST00000115443.1
met proto-oncogene
chr1_-_162898665 5.01 ENSMUST00000111510.1
flavin containing monooxygenase 2
chr18_+_20944607 4.53 ENSMUST00000050004.1
ring finger protein 125
chr1_-_140183404 3.95 ENSMUST00000066859.6
complement component factor h
chr1_-_140183283 3.90 ENSMUST00000111977.1
complement component factor h
chr9_-_103230415 3.41 ENSMUST00000035158.9
chr7_-_127273919 3.39 ENSMUST00000082428.3
selenophosphate synthetase 2
chr5_-_147894804 3.17 ENSMUST00000118527.1
solute carrier family 46, member 3
chr6_-_3968357 2.98 ENSMUST00000031674.8
tissue factor pathway inhibitor 2
chr9_-_103230262 2.98 ENSMUST00000165296.1
predicted gene 20425
chr17_-_85090204 2.72 ENSMUST00000072406.3
prolyl endopeptidase-like
chr5_+_7960445 2.62 ENSMUST00000115421.1
STEAP family member 4
chrX_+_94234594 2.61 ENSMUST00000153900.1
kelch-like 15
chr3_+_19957088 2.59 ENSMUST00000108328.1
chr11_-_77894096 2.55 ENSMUST00000017597.4
pipecolic acid oxidase
chr3_+_19957037 2.51 ENSMUST00000091309.5
chr16_-_23029062 2.27 ENSMUST00000115349.2
kininogen 2
chr16_-_23029012 2.16 ENSMUST00000039338.6
kininogen 2
chr16_-_23029080 2.12 ENSMUST00000100046.2
kininogen 2
chr11_-_106216318 2.11 ENSMUST00000002043.3
coiled-coil domain containing 47
chr3_+_19957240 2.06 ENSMUST00000108325.2
chr14_-_45477856 2.06 ENSMUST00000141424.1
fermitin family homolog 2 (Drosophila)
chr14_-_18893623 2.06 ENSMUST00000177259.1
ubiquitin-conjugating enzyme E2E 2
chr12_+_37241633 1.99 ENSMUST00000049874.7
alkylglycerol monooxygenase
chr14_-_68533689 1.98 ENSMUST00000022640.7
a disintegrin and metallopeptidase domain 7
chr14_+_75242287 1.93 ENSMUST00000022576.8
carboxypeptidase B2 (plasma)
chrX_-_162565514 1.91 ENSMUST00000154424.1
RALBP1 associated Eps domain containing protein 2
chr7_-_46715676 1.83 ENSMUST00000006956.7
serum amyloid A 3
chr6_+_29529277 1.80 ENSMUST00000163511.1
interferon regulatory factor 5
chr4_+_55350043 1.75 ENSMUST00000030134.8
RAD23b homolog (S. cerevisiae)
chr12_+_37241729 1.71 ENSMUST00000160768.1
alkylglycerol monooxygenase
chr8_+_94037198 1.66 ENSMUST00000109556.2
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr12_+_24572276 1.57 ENSMUST00000085553.5
grainyhead-like 1 (Drosophila)
chr14_-_18893376 1.57 ENSMUST00000151926.1
ubiquitin-conjugating enzyme E2E 2
chr13_+_63015167 1.56 ENSMUST00000021911.8
RIKEN cDNA 2010111I01 gene
chr4_-_108833608 1.53 ENSMUST00000102742.4
basic transcription factor 3-like 4
chr11_-_78080360 1.40 ENSMUST00000021183.3
Era (G-protein)-like 1 (E. coli)
chr13_+_16011851 1.38 ENSMUST00000042603.6
inhibin beta-A
chr13_+_63014934 1.36 ENSMUST00000091560.4
RIKEN cDNA 2010111I01 gene
chr5_+_63812447 1.29 ENSMUST00000081747.3
RIKEN cDNA 0610040J01 gene
chr12_+_86421628 1.24 ENSMUST00000110203.1
estrogen related receptor, beta
chr10_-_86011833 1.18 ENSMUST00000105304.1
BPI fold containing family C
chr10_+_67535465 1.15 ENSMUST00000145754.1
early growth response 2
chr2_+_136501978 0.98 ENSMUST00000061569.2
cDNA sequence BC034902
chr8_-_33929798 0.83 ENSMUST00000033995.7
RNA binding protein gene with multiple splicing
chrX_+_7763943 0.83 ENSMUST00000144900.1
transcription factor E3
chr10_+_67535493 0.80 ENSMUST00000145936.1
early growth response 2
chr7_-_16244152 0.76 ENSMUST00000171425.1
complement component 5a receptor 2
chr2_+_3513035 0.74 ENSMUST00000036350.2
cerebral dopamine neurotrophic factor
chr1_-_107161114 0.72 ENSMUST00000086694.4
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B
chr5_+_115279666 0.71 ENSMUST00000040421.4
coenzyme Q5 homolog, methyltransferase (yeast)
chr5_-_145140238 0.69 ENSMUST00000031627.8
PDGFA associated protein 1
chr10_+_33863935 0.68 ENSMUST00000092597.3
sulfotransferase family 3A, member 1
chr17_+_19362135 0.67 ENSMUST00000176107.1
vomeronasal 2, receptor 99
chr4_-_108833544 0.58 ENSMUST00000102740.1
basic transcription factor 3-like 4
chr2_-_41789078 0.57 ENSMUST00000167270.2
low density lipoprotein-related protein 1B (deleted in tumors)
chr3_-_89913144 0.56 ENSMUST00000029559.6
interleukin 6 receptor, alpha
chr11_+_6415443 0.53 ENSMUST00000132846.1
peptidylprolyl isomerase A
chr1_+_71653339 0.46 ENSMUST00000125934.1
apolipoprotein L 7d
chr11_-_48826655 0.46 ENSMUST00000104959.1
predicted gene 12184
chr5_+_145140362 0.45 ENSMUST00000162594.1
BUD31 homolog (yeast)
chr3_+_66219909 0.43 ENSMUST00000029421.5
pentraxin related gene
chr6_-_87809757 0.36 ENSMUST00000032134.7
RAB43, member RAS oncogene family
chr19_-_57239310 0.33 ENSMUST00000111559.1
actin-binding LIM protein 1
chr3_+_154762157 0.33 ENSMUST00000098496.3
cDNA sequence BC007180
chr11_-_87086752 0.29 ENSMUST00000020801.7
smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr2_-_129371131 0.24 ENSMUST00000028881.7
interleukin 1 beta
chr2_-_57113053 0.21 ENSMUST00000112627.1
nuclear receptor subfamily 4, group A, member 2
chr1_-_107052331 0.20 ENSMUST00000112717.1
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
chr9_+_99456243 0.11 ENSMUST00000163199.2
RIKEN cDNA 1600029I14 gene
chr19_+_8819401 0.10 ENSMUST00000096753.3
heterogeneous nuclear ribonucleoprotein U-like 2
chr11_-_48826500 0.08 ENSMUST00000161192.2
predicted gene 12184
chr2_+_139493913 0.07 ENSMUST00000110083.1
serine palmitoyltransferase, long chain base subunit 3
chr6_+_92869357 0.06 ENSMUST00000113434.1
predicted gene 15737
chr9_-_15112100 0.05 ENSMUST00000159985.1
hephaestin-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpd

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:2001293 fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293)
1.2 5.8 GO:0006548 histidine catabolic process(GO:0006548)
1.0 58.1 GO:0006953 acute-phase response(GO:0006953)
1.0 11.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
1.0 7.8 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.8 2.5 GO:0006553 lysine metabolic process(GO:0006553)
0.8 3.4 GO:0016259 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.8 5.0 GO:0072592 oxygen metabolic process(GO:0072592)
0.8 6.4 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.7 5.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.6 1.9 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.6 1.8 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.5 2.0 GO:0021664 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.5 3.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.4 2.6 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.3 1.2 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.3 9.8 GO:0006825 copper ion transport(GO:0006825)
0.3 1.4 GO:0060279 positive regulation of ovulation(GO:0060279)
0.2 3.7 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 8.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 2.1 GO:0006983 ER overload response(GO:0006983)
0.2 0.8 GO:0071623 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
0.2 0.6 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.2 1.7 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.4 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 0.4 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 6.5 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.6 GO:0002934 desmosome organization(GO:0002934)
0.1 2.9 GO:0043171 peptide catabolic process(GO:0043171)
0.1 2.7 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 8.9 GO:0031638 zymogen activation(GO:0031638)
0.1 0.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.8 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.8 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 4.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 15.2 GO:0032259 methylation(GO:0032259)
0.0 0.7 GO:0051923 sulfation(GO:0051923)
0.0 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 2.1 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.7 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.7 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.8 GO:0045670 regulation of osteoclast differentiation(GO:0045670)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.2 GO:0043203 axon hillock(GO:0043203)
0.6 6.4 GO:0097433 dense body(GO:0097433)
0.6 22.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.5 1.4 GO:0043512 inhibin A complex(GO:0043512)
0.4 1.8 GO:0071942 XPC complex(GO:0071942)
0.1 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 19.8 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0032039 integrator complex(GO:0032039)
0.1 5.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.8 GO:0005685 U1 snRNP(GO:0005685)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 41.1 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.2 3.7 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
1.2 6.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.1 7.8 GO:0001851 complement component C3b binding(GO:0001851)
0.9 6.4 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.8 5.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 7.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.7 22.0 GO:0042056 chemoattractant activity(GO:0042056)
0.6 2.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.6 3.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.5 5.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3 2.6 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.8 GO:0001847 opsonin receptor activity(GO:0001847)
0.2 0.6 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.2 0.8 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.2 15.2 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 2.7 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 1.7 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.1 8.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 13.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 8.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0001223 RNA polymerase II core binding(GO:0000993) transcription coactivator binding(GO:0001223)
0.0 0.6 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 2.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 1.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 7.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 17.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID ALK1 PATHWAY ALK1 signaling events
0.0 7.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.6 8.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.6 7.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 6.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 7.2 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 15.5 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 1.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 0.5 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 5.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 4.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 5.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 5.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling