GSE58827: Dynamics of the Mouse Liver


Results for Cdx2

Z-value: 0.66

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Transcription factors associated with Cdx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000029646.3 caudal type homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Cdx2 motif

Sorted Z-values of Cdx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_131032061 8.97 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr8_-_105933832 4.25 ENSMUST00000034368.6
chr7_+_140763739 3.40 ENSMUST00000026552.7
cytochrome P450, family 2, subfamily e, polypeptide 1
chr11_-_99438143 2.84 ENSMUST00000017743.2
keratin 20
chr9_-_65422773 2.67 ENSMUST00000065894.5
solute carrier family 51, beta subunit
chr1_-_89933290 2.33 ENSMUST00000036954.7
gastrulation brain homeobox 2
chr5_+_146079254 2.31 ENSMUST00000035571.8
cytochrome P450, family 3, subfamily a, polypeptide 59
chr3_-_90695706 1.96 ENSMUST00000069960.5
S100 calcium binding protein A9 (calgranulin B)
chrX_+_164090187 1.61 ENSMUST00000015545.3
transmembrane protein 27
chr14_+_80000292 1.33 ENSMUST00000088735.3
olfactomedin 4
chr17_+_80307396 1.13 ENSMUST00000068175.5
Rho guanine nucleotide exchange factor (GEF) 33
chr4_-_64046925 1.11 ENSMUST00000107377.3
tenascin C
chr6_-_49214954 1.03 ENSMUST00000031838.7
insulin-like growth factor 2 mRNA binding protein 3
chr11_-_99244058 0.96 ENSMUST00000103132.3
keratin 222
chrX_+_96455359 0.85 ENSMUST00000033553.7
chr1_-_144249134 0.82 ENSMUST00000172388.1
regulator of G-protein signaling 1
chr5_+_13399309 0.76 ENSMUST00000030714.7
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr11_+_96323253 0.76 ENSMUST00000093944.3
homeobox B3
chr18_+_65582239 0.70 ENSMUST00000182684.1
zinc finger protein 532
chrX_+_164140447 0.70 ENSMUST00000073973.4
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr19_-_47692042 0.68 ENSMUST00000026045.7
collagen, type XVII, alpha 1
chr3_+_57425314 0.66 ENSMUST00000029377.7
transmembrane 4 superfamily member 4
chr1_-_169747634 0.66 ENSMUST00000027991.5
regulator of G-protein signaling 4
chrX_+_13632769 0.61 ENSMUST00000096492.3
G protein-coupled receptor 34
chr15_-_101491509 0.61 ENSMUST00000023718.7
RIKEN cDNA 5430421N21 gene
chr5_-_135744206 0.54 ENSMUST00000153399.1
transmembrane protein 120A
chr18_+_65582390 0.53 ENSMUST00000169679.1
zinc finger protein 532
chr6_-_13839916 0.50 ENSMUST00000060442.7
G protein-coupled receptor 85
chr1_-_163289214 0.48 ENSMUST00000183691.1
paired related homeobox 1
chr4_-_137118135 0.48 ENSMUST00000154285.1
predicted gene 13001
chr12_-_102878406 0.45 ENSMUST00000045652.6
BTB (POZ) domain containing 7
chr3_-_92485886 0.43 ENSMUST00000054599.7
small proline-rich protein 1A
chr3_+_126597415 0.43 ENSMUST00000066452.7
calcium/calmodulin-dependent protein kinase II, delta
chr3_+_118433797 0.39 ENSMUST00000180593.1
predicted gene, 26871
chr14_-_54686060 0.38 ENSMUST00000125265.1
apoptotic chromatin condensation inducer 1
chr13_-_107890059 0.35 ENSMUST00000105097.2
zinc finger SWIM-type containing 6
chr12_+_85473883 0.35 ENSMUST00000021674.6
FBJ osteosarcoma oncogene
chr1_-_186705980 0.33 ENSMUST00000045288.8
transforming growth factor, beta 2
chr9_-_45936049 0.33 ENSMUST00000034590.2
chr6_+_38918969 0.31 ENSMUST00000003017.6
thromboxane A synthase 1, platelet
chr5_+_90460889 0.31 ENSMUST00000031314.8
chr3_+_95658771 0.31 ENSMUST00000178686.1
myeloid cell leukemia sequence 1
chr2_+_31759932 0.31 ENSMUST00000028190.6
c-abl oncogene 1, non-receptor tyrosine kinase
chr12_+_77238093 0.31 ENSMUST00000177595.1
fucosyltransferase 8
chr5_-_122697603 0.30 ENSMUST00000071235.4
predicted gene 10064
chr1_+_12692430 0.29 ENSMUST00000180062.1
sulfatase 1
chr6_+_17491216 0.27 ENSMUST00000080469.5
met proto-oncogene
chr3_+_126597299 0.25 ENSMUST00000106400.2
calcium/calmodulin-dependent protein kinase II, delta
chr10_+_69787431 0.25 ENSMUST00000183240.1
ankyrin 3, epithelial
chr8_-_33843562 0.23 ENSMUST00000183062.1
RNA binding protein gene with multiple splicing
chr18_+_37755718 0.23 ENSMUST00000061279.7
protocadherin gamma subfamily A, 9
chr3_-_10208569 0.23 ENSMUST00000029041.4
fatty acid binding protein 4, adipocyte
chr18_+_65582281 0.23 ENSMUST00000183319.1
zinc finger protein 532
chr6_+_71199827 0.21 ENSMUST00000067492.7
fatty acid binding protein 1, liver
chr2_+_31759993 0.18 ENSMUST00000124089.1
c-abl oncogene 1, non-receptor tyrosine kinase
chr8_+_54550324 0.18 ENSMUST00000033918.2
ankyrin repeat and SOCs box-containing 5
chr17_-_31129602 0.18 ENSMUST00000024827.4
trefoil factor 3, intestinal
chr3_+_95658714 0.17 ENSMUST00000037947.8
myeloid cell leukemia sequence 1
chr6_-_71262232 0.16 ENSMUST00000129630.2
SET and MYND domain containing 1
chr15_+_3270767 0.13 ENSMUST00000082424.4
selenoprotein P, plasma, 1
chrX_-_51205990 0.12 ENSMUST00000114876.2
muscleblind-like 3 (Drosophila)
chr5_+_121777929 0.08 ENSMUST00000160821.1
ataxin 2
chr3_-_14778452 0.07 ENSMUST00000094365.4
carbonic anhydrase 1
chr6_-_99044414 0.07 ENSMUST00000177507.1
forkhead box P1
chr6_-_122340525 0.06 ENSMUST00000112600.2
polyhomeotic-like 1 (Drosophila)
chr19_-_34879452 0.06 ENSMUST00000036584.5
pantothenate kinase 1
chr11_-_100105626 0.05 ENSMUST00000107416.2
keratin 36
chr2_+_4300462 0.05 ENSMUST00000175669.1
FERM domain containing 4A
chr18_+_11839220 0.04 ENSMUST00000171109.1
CDK5 and Abl enzyme substrate 1
chr13_+_63282142 0.04 ENSMUST00000159152.1
RIKEN cDNA 2010111I01 gene
chr8_+_94386486 0.04 ENSMUST00000034220.7
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_+_52391606 0.02 ENSMUST00000067085.4
chrX_+_139684980 0.02 ENSMUST00000096313.3
TBC1 domain family, member 8B
chr15_+_23036449 0.02 ENSMUST00000164787.1
cadherin 18
chr8_+_15057646 0.01 ENSMUST00000033842.3
myomesin 2
chr16_-_44016387 0.00 ENSMUST00000036174.3
GRAM domain containing 1C

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0070488 neutrophil aggregation(GO:0070488)
0.5 9.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 2.7 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.3 2.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.3 1.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 1.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.7 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.2 0.5 GO:1990051 negative regulation of phospholipase C activity(GO:1900275) activation of protein kinase C activity(GO:1990051)
0.2 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.8 GO:0021824 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 3.4 GO:0017144 drug metabolic process(GO:0017144)
0.1 0.7 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.1 0.3 GO:0035910 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 2.8 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.3 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.7 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.3 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.2 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.3 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.3 GO:0042581 specific granule(GO:0042581)
0.1 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 3.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.3 2.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.2 2.0 GO:0050786 Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
0.2 9.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0045545 syndecan binding(GO:0045545)
0.1 3.4 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 3.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 4.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 10.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation