ISMARA results: Arntl_Tfe3_Mlx_Mitf_Mlxipl

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GSE58827: Dynamics of the Mouse Liver

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Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 1.38

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Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Gene Symbol	Gene ID	Gene Info
Arntl Ensembl NCBI MGI UniProt	ENSMUSG00000055116.7	aryl hydrocarbon receptor nuclear translocator-like
Tfe3 Ensembl NCBI MGI UniProt	ENSMUSG00000000134.11	transcription factor E3
Mlx Ensembl NCBI MGI UniProt	ENSMUSG00000017801.9	MAX-like protein X
Mitf Ensembl NCBI MGI UniProt	ENSMUSG00000035158.9	melanogenesis associated transcription factor
Mlxipl Ensembl NCBI MGI UniProt	ENSMUSG00000005373.7	MLX interacting protein-like
Tfec Ensembl NCBI MGI UniProt	ENSMUSG00000029553.7	transcription factor EC

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfec	mm10_v2_chr6_-_16898441_16898459	-0.84	2.2e-10	Click!
Mlxipl	mm10_v2_chr5_+_135106881_135106918	0.75	1.5e-07	Click!
Arntl	mm10_v2_chr7_+_113207465_113207595	0.46	4.4e-03	Click!
Mlx	mm10_v2_chr11_+_101087277_101087323	0.45	5.3e-03	Click!
Tfe3	mm10_v2_chrX_+_7762652_7762695	-0.43	9.1e-03	Click!
Mitf	mm10_v2_chr6_+_97807014_97807067	0.26	1.2e-01	Click!

Activity profile of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Sorted Z-values of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_13159135 Show fit	25.04	ENSMUST00000033824.6	Lamp1 Ensembl NCBI MGI UniProt Show fit	lysosomal-associated membrane protein 1
chr1_+_130826676 Show fit	20.46	ENSMUST00000027675.7	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr1_+_130826762 Show fit	18.79	ENSMUST00000133792.1	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr7_-_97417730 Show fit	16.69	ENSMUST00000043077.7	Thrsp Ensembl NCBI MGI UniProt Show fit	thyroid hormone responsive
chr10_+_127063527 Show fit	13.55	ENSMUST00000006911.5	Cdk4 Ensembl NCBI MGI UniProt Show fit	cyclin-dependent kinase 4
chr3_+_90052814 Show fit	13.18	ENSMUST00000160640.1 ENSMUST00000029552.6 ENSMUST00000162114.1 ENSMUST00000068798.6	4933434E20Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4933434E20 gene
chr9_-_50561261 Show fit	12.92	ENSMUST00000034568.5	Tex12 Ensembl NCBI MGI UniProt Show fit	testis expressed gene 12
chr17_-_26939464 Show fit	12.16	ENSMUST00000025027.8 ENSMUST00000114935.1	Cuta Ensembl NCBI MGI UniProt Show fit	cutA divalent cation tolerance homolog (E. coli)
chr11_-_116199040 Show fit	11.76	ENSMUST00000066587.5	Acox1 Ensembl NCBI MGI UniProt Show fit	acyl-Coenzyme A oxidase 1, palmitoyl
chr1_+_166254095 Show fit	11.20	ENSMUST00000111416.1	Ildr2 Ensembl NCBI MGI UniProt Show fit	immunoglobulin-like domain containing receptor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.1	40.4	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.0	33.6	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.2	33.3	GO:0008643	carbohydrate transport(GO:0008643)
8.5	25.5	GO:0043323	positive regulation of natural killer cell degranulation(GO:0043323)
3.5	20.9	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.6	20.5	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
0.8	19.3	GO:0099514	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
3.8	15.3	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
2.5	15.3	GO:0010288	response to lead ion(GO:0010288)
3.8	15.2	GO:0071718	sodium-independent icosanoid transport(GO:0071718)

Showing 1 to 10 of 693 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	71.8	GO:0000323	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0	50.2	GO:0005739	mitochondrion(GO:0005739)
0.1	44.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.9	37.9	GO:0055038	recycling endosome membrane(GO:0055038)
0.4	32.5	GO:0009925	basal plasma membrane(GO:0009925)
0.2	28.8	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.7	25.7	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.3	25.3	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
8.3	25.0	GO:0032010	phagolysosome(GO:0032010)
0.0	19.8	GO:0005783	endoplasmic reticulum(GO:0005783)

Showing 1 to 10 of 222 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	41.0	GO:0019763	immunoglobulin receptor activity(GO:0019763)
1.0	27.2	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
3.5	20.9	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.4	19.5	GO:0016790	thiolester hydrolase activity(GO:0016790)
0.9	19.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.7	17.3	GO:0005351	sugar:proton symporter activity(GO:0005351)
0.3	15.3	GO:0030332	cyclin binding(GO:0030332)
4.8	14.4	GO:0004454	ketohexokinase activity(GO:0004454)
1.5	13.9	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1	13.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Showing 1 to 10 of 450 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	47.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	20.0	PID P73PATHWAY	p73 transcription factor network
0.2	14.4	PID LKB1 PATHWAY	LKB1 signaling events
0.9	14.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	12.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	10.4	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	9.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	8.0	PID IL2 1PATHWAY	IL2-mediated signaling events
0.2	6.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.3	6.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	32.1	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
1.3	29.5	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.6	23.2	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.5	18.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.6	16.1	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.2	14.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.1	14.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4	14.0	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.6	13.1	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
1.1	12.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions

Showing 1 to 10 of 144 entries

Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 1.38

Motif logo

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Activity-expression correlation:

Activity profile of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Sorted Z-values of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: