ISMARA results: ZNF711_TFAP2A

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF711_TFAP2A_TFAP2D

Z-value: 1.88

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Transcription factors associated with ZNF711_TFAP2A_TFAP2D

Gene Symbol	Gene ID	Gene Info
ZNF711 Ensembl NCBI GeneCards UniProt	ENSG00000147180.12	zinc finger protein 711
TFAP2A Ensembl NCBI GeneCards UniProt	ENSG00000137203.6	transcription factor AP-2 alpha
TFAP2D Ensembl NCBI GeneCards UniProt	ENSG00000008197.4	transcription factor AP-2 delta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFAP2A	hg19_v2_chr6_-_10413112_10413132	-0.55	2.6e-01	Click!
ZNF711	hg19_v2_chrX_+_84499081_84499115	-0.32	5.4e-01	Click!

Activity profile of ZNF711_TFAP2A_TFAP2D motif

Sorted Z-values of ZNF711_TFAP2A_TFAP2D motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_38083977 Show fit	1.68	ENST00000578802.1 ENST00000578478.1 ENST00000582263.1	RP11-387H17.4 Ensembl NCBI GeneCards UniProt Show fit	RP11-387H17.4
chr9_-_139981121 Show fit	1.65	ENST00000596585.1	AL807752.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr8_-_42752418 Show fit	1.59	ENST00000524954.1	RNF170 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 170
chr7_+_26438187 Show fit	1.43	ENST00000439120.1 ENST00000430548.1 ENST00000421862.1 ENST00000449537.1 ENST00000420774.1 ENST00000418758.2	AC004540.5 Ensembl NCBI GeneCards UniProt Show fit	AC004540.5
chr9_-_140115775 Show fit	1.33	ENST00000391553.1 ENST00000392827.1	RNF208 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 208
chr6_+_84563295 Show fit	1.33	ENST00000369687.1	RIPPLY2 Ensembl NCBI GeneCards UniProt Show fit	ripply transcriptional repressor 2
chr12_+_104235229 Show fit	1.29	ENST00000551650.1	RP11-650K20.3 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr2_-_240322685 Show fit	1.19	ENST00000544989.1	HDAC4 Ensembl NCBI GeneCards UniProt Show fit	histone deacetylase 4
chr11_+_130184888 Show fit	1.16	ENST00000602376.1 ENST00000532116.3 ENST00000602310.1	RP11-121M22.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-121M22.1
chr3_+_14989186 Show fit	1.13	ENST00000435454.1 ENST00000323373.6	NR2C2 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 2, group C, member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF711_TFAP2A_TFAP2D

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0006004	fucose metabolic process(GO:0006004)
0.1	2.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	1.9	GO:0045008	depyrimidination(GO:0045008)
0.1	1.9	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990)
0.0	1.9	GO:0070830	bicellular tight junction assembly(GO:0070830)
0.1	1.8	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	1.8	GO:0007044	cell-substrate junction assembly(GO:0007044)
0.1	1.7	GO:0035729	cellular response to hepatocyte growth factor stimulus(GO:0035729)
0.1	1.6	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.1	1.6	GO:2001135	regulation of endocytic recycling(GO:2001135)

Showing 1 to 10 of 1,359 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.8	GO:0005923	bicellular tight junction(GO:0005923)
0.0	4.4	GO:0001726	ruffle(GO:0001726)
0.0	3.2	GO:0042641	actomyosin(GO:0042641)
0.1	2.2	GO:0031527	filopodium membrane(GO:0031527)
0.0	2.2	GO:0055037	recycling endosome(GO:0055037)
0.0	2.2	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.0	2.1	GO:0043202	lysosomal lumen(GO:0043202)
0.1	1.9	GO:0030056	hemidesmosome(GO:0030056)
0.0	1.8	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	1.7	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)

Showing 1 to 10 of 387 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	3.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	2.8	GO:0042162	telomeric DNA binding(GO:0042162)
0.1	2.7	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	2.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	2.4	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	2.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	2.0	GO:0043274	phospholipase binding(GO:0043274)
0.0	2.0	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	1.7	GO:0017049	GTP-Rho binding(GO:0017049)

Showing 1 to 10 of 744 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	PID IGF1 PATHWAY	IGF1 pathway
0.0	3.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	3.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	3.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.7	NABA COLLAGENS	Genes encoding collagen proteins
0.0	2.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	2.3	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	2.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	2.0	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.7	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Showing 1 to 10 of 98 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.0	2.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	2.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	2.1	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	2.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.8	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	1.8	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.1	1.6	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	1.5	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis

Showing 1 to 10 of 128 entries

Results for ZNF711_TFAP2A_TFAP2D

Z-value: 1.88

Motif logo

Transcription factors associated with ZNF711_TFAP2A_TFAP2D

Activity-expression correlation:

Activity profile of ZNF711_TFAP2A_TFAP2D motif

Sorted Z-values of ZNF711_TFAP2A_TFAP2D motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF711_TFAP2A_TFAP2D

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: