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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF423

Z-value: 0.45

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49891694_49891830-0.364.9e-01Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_33663474 0.40 ENST00000594414.1
SBP1; Uncharacterized protein
chr16_+_27324983 0.25 ENST00000566117.1
interleukin 4 receptor
chr16_-_2162831 0.19 ENST00000483024.1
polycystic kidney disease 1 (autosomal dominant)
chr18_-_60985914 0.18 ENST00000589955.1
B-cell CLL/lymphoma 2
chr15_-_41522889 0.16 ENST00000458580.2
ENST00000314992.5
ENST00000558396.1
exonuclease 3'-5' domain containing 1
chr12_+_7342271 0.16 ENST00000434354.2
ENST00000544456.1
ENST00000545574.1
ENST00000420616.2
peroxisomal biogenesis factor 5
chr5_+_72509751 0.15 ENST00000515556.1
ENST00000513379.1
ENST00000427584.2
RP11-60A8.1
chr1_-_204121298 0.14 ENST00000367199.2
ethanolamine kinase 2
chr19_-_5292781 0.14 ENST00000586065.1
protein tyrosine phosphatase, receptor type, S
chr16_+_71392616 0.14 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
calbindin 2
chr19_+_14544099 0.13 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
protein kinase N1
chr7_+_20370746 0.13 ENST00000222573.4
integrin, beta 8
chr17_-_79212825 0.13 ENST00000374769.2
ENTH domain containing 2
chr12_+_7342441 0.12 ENST00000412720.2
ENST00000396637.3
peroxisomal biogenesis factor 5
chr5_+_150400124 0.12 ENST00000388825.4
ENST00000521650.1
ENST00000517973.1
glutathione peroxidase 3 (plasma)
chr2_-_206950996 0.11 ENST00000414320.1
INO80 complex subunit D
chr17_+_36584662 0.11 ENST00000431231.2
ENST00000437668.3
Rho GTPase activating protein 23
chr7_-_27219632 0.11 ENST00000470747.4
Uncharacterized protein
chr1_+_24118452 0.11 ENST00000421070.1
lysophospholipase II
chr8_-_80680078 0.11 ENST00000337919.5
ENST00000354724.3
hes-related family bHLH transcription factor with YRPW motif 1
chr16_+_27325202 0.10 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
interleukin 4 receptor
chr15_-_75660919 0.10 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
mannosidase, alpha, class 2C, member 1
chr1_+_1222489 0.10 ENST00000379099.3
sodium channel, non-voltage-gated 1, delta subunit
chr12_+_52643077 0.10 ENST00000553310.2
ENST00000544024.1
keratin 86
chr5_+_141303461 0.10 ENST00000508751.1
KIAA0141
chr19_-_56110859 0.10 ENST00000221665.3
ENST00000592585.1
FLT3-interacting zinc finger 1
chr5_+_154181816 0.09 ENST00000518677.1
La ribonucleoprotein domain family, member 1
chr9_-_35619539 0.09 ENST00000396757.1
CD72 molecule
chr8_+_22422749 0.09 ENST00000523900.1
sorbin and SH3 domain containing 3
chr1_-_155177677 0.08 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
thrombospondin 3
chr8_+_22022223 0.08 ENST00000306385.5
bone morphogenetic protein 1
chr19_+_41770349 0.08 ENST00000602130.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_-_204121102 0.08 ENST00000367202.4
ethanolamine kinase 2
chr20_+_44462481 0.08 ENST00000491381.1
ENST00000342644.5
ENST00000372542.1
sorting nexin family member 21
chr8_+_22423219 0.08 ENST00000523965.1
ENST00000521554.1
sorbin and SH3 domain containing 3
chr17_-_27230035 0.08 ENST00000378895.4
ENST00000394901.3
dehydrogenase/reductase (SDR family) member 13
chr14_+_100204027 0.07 ENST00000554479.1
ENST00000555145.1
echinoderm microtubule associated protein like 1
chr11_-_61659006 0.07 ENST00000278829.2
fatty acid desaturase 3
chr2_-_120980939 0.07 ENST00000426077.2
transmembrane protein 185B
chr11_-_47207950 0.07 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
protein kinase C and casein kinase substrate in neurons 3
chr19_-_36391434 0.07 ENST00000396901.1
ENST00000585925.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr12_-_50101165 0.07 ENST00000352151.5
ENST00000335154.5
ENST00000293590.5
formin-like 3
chr11_+_60691924 0.07 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
transmembrane protein 132A
chr9_-_131486367 0.07 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
zinc finger, DHHC-type containing 12
chr11_-_504489 0.07 ENST00000529368.1
ribonuclease/angiogenin inhibitor 1
chr19_+_10531150 0.07 ENST00000352831.6
phosphodiesterase 4A, cAMP-specific
chr14_-_93582148 0.07 ENST00000267615.6
ENST00000553452.1
inositol-tetrakisphosphate 1-kinase
chr1_-_33366931 0.07 ENST00000373463.3
ENST00000329151.5
transmembrane protein 54
chr2_+_135011731 0.07 ENST00000281923.2
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr17_-_1029052 0.06 ENST00000574437.1
active BCR-related
chr1_-_35658736 0.06 ENST00000357214.5
splicing factor proline/glutamine-rich
chr8_+_22423168 0.06 ENST00000518912.1
ENST00000428103.1
sorbin and SH3 domain containing 3
chr19_+_41770269 0.06 ENST00000378215.4
heterogeneous nuclear ribonucleoprotein U-like 1
chr17_-_48227877 0.06 ENST00000316878.6
protein phosphatase 1, regulatory subunit 9B
chr17_+_6347761 0.06 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr5_+_141303373 0.06 ENST00000432126.2
ENST00000194118.4
KIAA0141
chr17_+_6347729 0.06 ENST00000572447.1
family with sequence similarity 64, member A
chr22_-_37823468 0.06 ENST00000402918.2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr20_+_43029911 0.06 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
hepatocyte nuclear factor 4, alpha
chr12_+_54410664 0.06 ENST00000303406.4
homeobox C4
chr19_-_23941680 0.06 ENST00000402377.3
zinc finger protein 681
chr19_-_4066890 0.06 ENST00000322357.4
zinc finger and BTB domain containing 7A
chr14_-_93582214 0.06 ENST00000556603.2
ENST00000354313.3
inositol-tetrakisphosphate 1-kinase
chr9_+_116638562 0.05 ENST00000374126.5
ENST00000288466.7
zinc finger protein 618
chr17_+_77020224 0.05 ENST00000339142.2
C1q and tumor necrosis factor related protein 1
chr3_+_9958758 0.05 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
interleukin 17 receptor C
chr6_+_42896865 0.05 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr6_+_33589161 0.05 ENST00000605930.1
inositol 1,4,5-trisphosphate receptor, type 3
chr11_-_6495101 0.05 ENST00000528227.1
ENST00000359518.3
ENST00000345851.3
ENST00000537602.1
tripartite motif containing 3
chr22_-_38484922 0.05 ENST00000428572.1
BAI1-associated protein 2-like 2
chr17_+_77020146 0.05 ENST00000579760.1
C1q and tumor necrosis factor related protein 1
chr7_+_101460882 0.05 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
cut-like homeobox 1
chr17_+_77020325 0.05 ENST00000311661.4
C1q and tumor necrosis factor related protein 1
chr8_+_22022653 0.05 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
bone morphogenetic protein 1
chr10_-_118032979 0.05 ENST00000355422.6
GDNF family receptor alpha 1
chr7_-_30029328 0.05 ENST00000425819.2
ENST00000409570.1
secernin 1
chr12_-_125348448 0.04 ENST00000339570.5
scavenger receptor class B, member 1
chr20_-_36794938 0.04 ENST00000453095.1
transglutaminase 2
chr8_+_145065521 0.04 ENST00000534791.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr12_-_125348329 0.04 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
scavenger receptor class B, member 1
chr20_+_44462430 0.04 ENST00000462307.1
sorting nexin family member 21
chr9_-_130659569 0.04 ENST00000542456.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr6_+_151187074 0.04 ENST00000367308.4
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_-_5570229 0.04 ENST00000331789.5
actin, beta
chr1_-_204121013 0.04 ENST00000367201.3
ethanolamine kinase 2
chr11_+_73019282 0.04 ENST00000263674.3
Rho guanine nucleotide exchange factor (GEF) 17
chr20_-_36794902 0.04 ENST00000373403.3
transglutaminase 2
chr3_+_196439275 0.04 ENST00000296333.5
phosphatidylinositol glycan anchor biosynthesis, class X
chr19_-_4043154 0.04 ENST00000535853.1
AC016586.1
chr12_-_50101003 0.04 ENST00000550488.1
formin-like 3
chr19_-_10450287 0.04 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr19_-_10679644 0.04 ENST00000393599.2
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr3_-_196439065 0.04 ENST00000399942.4
ENST00000409690.3
centrosomal protein 19kDa
chr9_-_130742792 0.04 ENST00000373095.1
family with sequence similarity 102, member A
chr9_+_131549610 0.04 ENST00000223865.8
TBC1 domain family, member 13
chr8_+_22022800 0.04 ENST00000397814.3
bone morphogenetic protein 1
chr8_+_30241934 0.04 ENST00000538486.1
RNA binding protein with multiple splicing
chr3_+_9958870 0.04 ENST00000413608.1
interleukin 17 receptor C
chr3_-_52931557 0.04 ENST00000504329.1
ENST00000355083.5
TMEM110-MUSTN1 readthrough
transmembrane protein 110
chr11_-_44972418 0.03 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
tumor protein p53 inducible protein 11
chr9_-_130659679 0.03 ENST00000373141.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr8_+_30241995 0.03 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RNA binding protein with multiple splicing
chr11_-_44971702 0.03 ENST00000533940.1
ENST00000533937.1
tumor protein p53 inducible protein 11
chr6_-_143266297 0.03 ENST00000367603.2
human immunodeficiency virus type I enhancer binding protein 2
chr17_+_7341586 0.03 ENST00000575235.1
fibroblast growth factor 11
chr1_+_17914907 0.03 ENST00000375420.3
Rho guanine nucleotide exchange factor (GEF) 10-like
chr19_-_38714847 0.03 ENST00000420980.2
ENST00000355526.4
D4, zinc and double PHD fingers family 1
chr12_+_7037461 0.03 ENST00000396684.2
atrophin 1
chr20_+_44462749 0.03 ENST00000372541.1
sorting nexin family member 21
chr2_-_46769694 0.03 ENST00000522587.1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr19_-_10450328 0.03 ENST00000160262.5
intercellular adhesion molecule 3
chr16_-_11681023 0.03 ENST00000570904.1
ENST00000574701.1
lipopolysaccharide-induced TNF factor
chr19_-_11689803 0.03 ENST00000591319.1
acid phosphatase 5, tartrate resistant
chr11_-_6495082 0.03 ENST00000536344.1
tripartite motif containing 3
chr19_-_15311713 0.03 ENST00000601011.1
ENST00000263388.2
notch 3
chr19_+_41770236 0.03 ENST00000392006.3
heterogeneous nuclear ribonucleoprotein U-like 1
chr7_-_27219849 0.02 ENST00000396344.4
homeobox A10
chr22_-_43045574 0.02 ENST00000352397.5
cytochrome b5 reductase 3
chr12_-_57522813 0.02 ENST00000556155.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr21_+_45432174 0.02 ENST00000380221.3
ENST00000291574.4
trafficking protein particle complex 10
chr7_-_100491854 0.02 ENST00000426415.1
ENST00000430554.1
ENST00000412389.1
acetylcholinesterase (Yt blood group)
chr11_-_67120974 0.02 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr10_-_100027943 0.02 ENST00000260702.3
lysyl oxidase-like 4
chr11_-_44972299 0.02 ENST00000528473.1
tumor protein p53 inducible protein 11
chr13_-_46626847 0.02 ENST00000242848.4
ENST00000282007.3
zinc finger CCCH-type containing 13
chr22_-_31742218 0.02 ENST00000266269.5
ENST00000405309.3
ENST00000351933.4
POZ (BTB) and AT hook containing zinc finger 1
chr9_+_130160440 0.02 ENST00000439597.1
ENST00000423934.1
solute carrier family 2 (facilitated glucose transporter), member 8
chr10_+_88428370 0.02 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LIM domain binding 3
chr19_+_55795493 0.02 ENST00000309383.1
BR serine/threonine kinase 1
chr16_+_70148230 0.02 ENST00000398122.3
ENST00000568530.1
pyruvate dehydrogenase phosphatase regulatory subunit
chr9_-_16870704 0.02 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
basonuclin 2
chr6_-_35480640 0.02 ENST00000428978.1
ENST00000322263.4
tubby like protein 1
chr4_-_120548779 0.02 ENST00000264805.5
phosphodiesterase 5A, cGMP-specific
chr15_+_41523417 0.02 ENST00000560397.1
calcineurin-like EF-hand protein 1
chr9_+_112542591 0.02 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr8_+_145065705 0.02 ENST00000533044.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr5_-_176057365 0.02 ENST00000310112.3
synuclein, beta
chr9_-_39239171 0.01 ENST00000358144.2
contactin associated protein-like 3
chr12_-_54779511 0.01 ENST00000551109.1
ENST00000546970.1
zinc finger protein 385A
chr19_-_57183114 0.01 ENST00000537055.2
ENST00000601659.1
zinc finger protein 835
chr5_-_172756506 0.01 ENST00000265087.4
stanniocalcin 2
chr11_-_61658853 0.01 ENST00000525588.1
ENST00000540820.1
fatty acid desaturase 3
chr12_+_7342178 0.01 ENST00000266563.5
ENST00000543974.1
peroxisomal biogenesis factor 5
chr9_+_139249228 0.01 ENST00000392944.1
G-protein signaling modulator 1
chr7_+_150748288 0.01 ENST00000490540.1
acid-sensing (proton-gated) ion channel 3
chr1_-_203055129 0.01 ENST00000241651.4
myogenin (myogenic factor 4)
chr10_-_121296045 0.01 ENST00000392865.1
regulator of G-protein signaling 10
chr6_+_30130969 0.01 ENST00000376694.4
tripartite motif containing 15
chr19_+_45582453 0.01 ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
ENST00000587566.1
gem (nuclear organelle) associated protein 7
MAP/microtubule affinity-regulating kinase 4
chr21_-_18985230 0.01 ENST00000457956.1
ENST00000348354.6
BTG family, member 3
chr6_+_151186554 0.01 ENST00000367321.3
ENST00000367307.4
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr5_+_135385202 0.01 ENST00000514554.1
transforming growth factor, beta-induced, 68kDa
chr10_+_17271266 0.01 ENST00000224237.5
vimentin
chr16_+_30675654 0.00 ENST00000287468.5
ENST00000395073.2
fibrosin
chr22_+_35653445 0.00 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr3_+_196439170 0.00 ENST00000392391.3
ENST00000314118.4
phosphatidylinositol glycan anchor biosynthesis, class X
chr4_+_74735102 0.00 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr12_-_118810688 0.00 ENST00000542532.1
ENST00000392533.3
TAO kinase 3
chrX_-_1572629 0.00 ENST00000534940.1
acetylserotonin O-methyltransferase-like
chr15_-_59225844 0.00 ENST00000380516.2
SAFB-like, transcription modulator
chr16_+_3014269 0.00 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
kringle containing transmembrane protein 2
chr1_+_155278625 0.00 ENST00000368356.4
ENST00000356657.6
farnesyl diphosphate synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.1 0.3 GO:1901091 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.0 0.1 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.2 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.2 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 0.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.1 GO:0072752 cellular response to rapamycin(GO:0072752)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990923 PET complex(GO:1990923)
0.0 0.2 GO:0002133 polycystin complex(GO:0002133)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.0 0.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.1 GO:0052825 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.3 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.1 GO:0035374 chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport