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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZBTB33_CHD2
Z-value: 2.21
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg19_v2_chr15_+_93447675_93447703 | 0.88 | 2.1e-02 | Click! |
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | 0.86 | 2.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.4 | 5.3 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 4.5 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 4.1 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.7 | 2.9 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.0 | 2.8 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.3 | 2.6 | GO:1905068 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.1 | 2.5 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.2 | 2.3 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 2.3 | GO:0010838 | positive regulation of keratinocyte proliferation(GO:0010838) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 4.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 3.3 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.2 | 3.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.3 | 2.8 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.3 | 2.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.2 | 2.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 2.1 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 2.1 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 2.0 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 4.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.4 | 4.2 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.1 | 3.0 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.5 | 2.9 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.1 | 2.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 2.7 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 2.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 2.6 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.5 | 2.1 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 5.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.0 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 3.0 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 2.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 4.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 2.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 2.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 2.3 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.1 | 2.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.2 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 2.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |