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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for YY1_YY2
Z-value: 1.52
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY2 | hg19_v2_chrX_+_21874105_21874105 | 0.65 | 1.6e-01 | Click! |
| YY1 | hg19_v2_chr14_+_100705322_100705360 | 0.12 | 8.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.9 | 3.5 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 2.9 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.1 | 2.0 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 1.7 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 1.7 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.0 | 1.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.3 | 1.4 | GO:2000314 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.0 | 1.4 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 2.3 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 1.7 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.1 | 1.6 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 1.6 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 1.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 1.5 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.0 | 1.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.1 | 2.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 2.1 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.5 | 1.9 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 1.8 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
| 0.2 | 1.6 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.0 | 1.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 1.5 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.4 | GO:0005080 | protein kinase C binding(GO:0005080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.9 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 3.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 3.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 2.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 2.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 1.6 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 1.5 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 1.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |