ISMARA results: YBX1_FOS_NFYC_NFYA_NFYB

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 1.79

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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Gene Symbol	Gene ID	Gene Info
YBX1 Ensembl NCBI GeneCards UniProt	ENSG00000065978.13	Y-box binding protein 1
FOS Ensembl NCBI GeneCards UniProt	ENSG00000170345.5	Fos proto-oncogene, AP-1 transcription factor subunit
NFYC Ensembl NCBI GeneCards UniProt	ENSG00000066136.15	nuclear transcription factor Y subunit gamma
NFYA Ensembl NCBI GeneCards UniProt	ENSG00000001167.10	nuclear transcription factor Y subunit alpha
NFYB Ensembl NCBI GeneCards UniProt	ENSG00000120837.3	nuclear transcription factor Y subunit beta
CEBPZ Ensembl NCBI GeneCards UniProt	ENSG00000115816.9	CCAAT enhancer binding protein zeta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOS	hg19_v2_chr14_+_75746664_75746683	-0.73	1.0e-01	Click!
CEBPZ	hg19_v2_chr2_-_37458749_37458856	-0.70	1.2e-01	Click!
YBX1	hg19_v2_chr1_+_43148625_43148710	0.69	1.3e-01	Click!
NFYC	hg19_v2_chr1_+_41157361_41157416	0.64	1.7e-01	Click!
NFYA	hg19_v2_chr6_+_41040678_41040722	-0.63	1.8e-01	Click!
NFYB	hg19_v2_chr12_-_104532062_104532071	-0.53	2.8e-01	Click!

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_74261413 Show fit	1.70	ENST00000587913.1	UBALD2 Ensembl NCBI GeneCards UniProt Show fit	UBA-like domain containing 2
chr3_+_119814070 Show fit	1.42	ENST00000469070.1	RP11-18H7.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-18H7.1
chr8_-_11660077 Show fit	1.28	ENST00000533405.1	RP11-297N6.4 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr17_+_74261277 Show fit	1.22	ENST00000327490.6	UBALD2 Ensembl NCBI GeneCards UniProt Show fit	UBA-like domain containing 2
chr16_+_57769635 Show fit	1.13	ENST00000379661.3 ENST00000562592.1 ENST00000566726.1	KATNB1 Ensembl NCBI GeneCards UniProt Show fit	katanin p80 (WD repeat containing) subunit B 1
chr12_-_113658826 Show fit	1.12	ENST00000546692.1	IQCD Ensembl NCBI GeneCards UniProt Show fit	IQ motif containing D
chr1_+_228645796 Show fit	1.10	ENST00000369160.2	HIST3H2BB Ensembl NCBI GeneCards UniProt Show fit	histone cluster 3, H2bb
chr12_+_110011571 Show fit	0.94	ENST00000539696.1 ENST00000228510.3 ENST00000392727.3	MVK Ensembl NCBI GeneCards UniProt Show fit	mevalonate kinase
chr6_+_26273144 Show fit	0.90	ENST00000377733.2	HIST1H2BI Ensembl NCBI GeneCards UniProt Show fit	histone cluster 1, H2bi
chr9_+_131843377 Show fit	0.78	ENST00000372546.4 ENST00000406974.3 ENST00000540102.1	DOLPP1 Ensembl NCBI GeneCards UniProt Show fit	dolichyldiphosphatase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2	1.5	GO:0070370	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0	1.5	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.2	1.4	GO:0019470	4-hydroxyproline catabolic process(GO:0019470)
0.4	1.3	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	1.3	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0	1.3	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	1.2	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	1.2	GO:0006342	chromatin silencing(GO:0006342)
0.0	1.2	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Showing 1 to 10 of 461 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0000786	nucleosome(GO:0000786)
0.0	1.6	GO:0016235	aggresome(GO:0016235)
0.0	1.6	GO:0031228	intrinsic component of Golgi membrane(GO:0031228)
0.0	1.4	GO:0097525	spliceosomal snRNP complex(GO:0097525)
0.1	1.3	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	1.3	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	1.1	GO:0000836	Hrd1p ubiquitin ligase complex(GO:0000836)
0.1	1.0	GO:0070435	Shc-EGFR complex(GO:0070435)
0.1	0.9	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.9	GO:0060077	inhibitory synapse(GO:0060077)

Showing 1 to 10 of 163 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.4	1.3	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.0	1.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1	1.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	1.0	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	1.0	GO:0031489	myosin V binding(GO:0031489)
0.0	1.0	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.1	0.9	GO:0005131	growth hormone receptor binding(GO:0005131)
0.1	0.9	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.9	GO:0000062	fatty-acyl-CoA binding(GO:0000062)

Showing 1 to 10 of 302 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	1.8	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	1.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.5	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	1.4	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.0	ST GA12 PATHWAY	G alpha 12 Pathway

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	1.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	1.3	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	1.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	1.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	1.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	1.1	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	1.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	1.0	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	0.9	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis

Showing 1 to 10 of 57 entries

Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 1.79

Motif logo

Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Activity-expression correlation:

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: