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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for XBP1
Z-value: 0.84
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg19_v2_chr22_-_29196511_29196541 | -0.48 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_50031547 Show fit | 2.17 |
ENST00000597801.1
|
reticulocalbin 3, EF-hand calcium binding domain |
|
| chr20_-_62199427 Show fit | 0.73 |
ENST00000427522.2
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr22_+_46476192 Show fit | 0.73 |
ENST00000443490.1
|
hsa-mir-4763 |
|
| chr10_-_18948208 Show fit | 0.67 |
ENST00000607346.1
|
ARL5B antisense RNA 1 |
|
| chr1_+_92495528 Show fit | 0.63 |
ENST00000370383.4
|
epoxide hydrolase 4 |
|
| chr5_+_119799927 Show fit | 0.59 |
ENST00000407149.2
ENST00000379551.2 |
proline rich 16 |
|
| chr11_+_17298522 Show fit | 0.58 |
ENST00000529313.1
|
nucleobindin 2 |
|
| chr11_+_17298297 Show fit | 0.51 |
ENST00000529010.1
|
nucleobindin 2 |
|
| chr9_-_34523027 Show fit | 0.48 |
ENST00000399775.2
|
energy homeostasis associated |
|
| chr22_+_38864041 Show fit | 0.46 |
ENST00000216014.4
ENST00000409006.3 |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.7 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.7 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.6 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.6 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 0.5 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.1 | 0.5 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 0.5 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 0.4 | GO:0030581 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.0 | 0.4 | GO:0021978 | telencephalon regionalization(GO:0021978) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.4 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 0.0 | 0.4 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.4 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.3 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 0.2 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.0 | 0.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 0.2 | GO:0045298 | tubulin complex(GO:0045298) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.6 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.2 | 0.5 | GO:0071566 | UFM1 activating enzyme activity(GO:0071566) |
| 0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.3 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
| 0.0 | 0.3 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.2 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.0 | 0.2 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |