ISMARA results: WT1_MTF1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for WT1_MTF1_ZBTB7B

Z-value: 0.83

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Transcription factors associated with WT1_MTF1_ZBTB7B

Gene Symbol	Gene ID	Gene Info
WT1 Ensembl NCBI GeneCards UniProt	ENSG00000184937.8	WT1 transcription factor
MTF1 Ensembl NCBI GeneCards UniProt	ENSG00000188786.9	metal regulatory transcription factor 1
ZBTB7B Ensembl NCBI GeneCards UniProt	ENSG00000160685.9	zinc finger and BTB domain containing 7B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB7B	hg19_v2_chr1_+_154975110_154975149	0.86	2.8e-02	Click!
WT1	hg19_v2_chr11_-_32457075_32457095	0.47	3.5e-01	Click!
MTF1	hg19_v2_chr1_-_38325256_38325292	0.01	9.8e-01	Click!

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_20866424 Show fit	0.78	ENST00000272224.3	GDF7 Ensembl NCBI GeneCards UniProt Show fit	growth differentiation factor 7
chr7_+_149411860 Show fit	0.71	ENST00000486744.1	KRBA1 Ensembl NCBI GeneCards UniProt Show fit	KRAB-A domain containing 1
chr5_+_92228 Show fit	0.71	ENST00000512035.1	CTD-2231H16.1 Ensembl NCBI GeneCards UniProt Show fit	CTD-2231H16.1
chr2_+_74212073 Show fit	0.68	ENST00000441217.1	AC073046.25 Ensembl NCBI GeneCards UniProt Show fit	AC073046.25
chr8_+_61592073 Show fit	0.65	ENST00000526846.1	CHD7 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 7
chr6_+_44095263 Show fit	0.63	ENST00000532634.1	TMEM63B Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 63B
chr15_-_32162833 Show fit	0.61	ENST00000560598.1	OTUD7A Ensembl NCBI GeneCards UniProt Show fit	OTU domain containing 7A
chr7_+_97910962 Show fit	0.56	ENST00000539286.1	BRI3 Ensembl NCBI GeneCards UniProt Show fit	brain protein I3
chr2_+_105471969 Show fit	0.56	ENST00000361360.2	POU3F3 Ensembl NCBI GeneCards UniProt Show fit	POU class 3 homeobox 3
chr3_-_53080047 Show fit	0.53	ENST00000482396.1 ENST00000358080.2 ENST00000296295.6 ENST00000394752.3	SFMBT1 Ensembl NCBI GeneCards UniProt Show fit	Scm-like with four mbt domains 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1	1.1	GO:0035330	regulation of hippo signaling(GO:0035330)
0.0	1.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	1.1	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	1.1	GO:0036498	IRE1-mediated unfolded protein response(GO:0036498)
0.1	1.0	GO:0021553	olfactory nerve development(GO:0021553)
0.0	1.0	GO:0006972	hyperosmotic response(GO:0006972)
0.0	1.0	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	1.0	GO:0018146	keratan sulfate biosynthetic process(GO:0018146)
0.1	0.9	GO:2000628	regulation of miRNA metabolic process(GO:2000628)

Showing 1 to 10 of 997 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	1.8	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	1.5	GO:0071565	nBAF complex(GO:0071565)
0.0	1.4	GO:0031143	pseudopodium(GO:0031143)
0.0	1.4	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	1.3	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	1.1	GO:0043198	dendritic shaft(GO:0043198)
0.1	0.9	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	0.9	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.8	GO:0045171	intercellular bridge(GO:0045171)

Showing 1 to 10 of 294 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0051087	chaperone binding(GO:0051087)
0.0	1.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	1.2	GO:0017166	vinculin binding(GO:0017166)
0.0	1.2	GO:0038191	neuropilin binding(GO:0038191)
0.0	1.1	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	1.1	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.1	1.0	GO:0030957	Tat protein binding(GO:0030957)
0.0	1.0	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	1.0	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	1.0	GO:0003924	GTPase activity(GO:0003924)

Showing 1 to 10 of 580 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
4.1	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
2.6	PID RB 1PATHWAY	Regulation of retinoblastoma protein
2.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
1.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.6	PID AURORA A PATHWAY	Aurora A signaling
1.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.4	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
1.3	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Showing 1 to 10 of 61 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
3.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
2.9	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
2.1	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
1.5	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
1.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.4	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
1.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.3	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
1.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis

Showing 1 to 10 of 89 entries

Results for WT1_MTF1_ZBTB7B

Z-value: 0.83

Motif logo

Transcription factors associated with WT1_MTF1_ZBTB7B

Activity-expression correlation:

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: