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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for UACAGUA
Z-value: 0.83
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miRNA associated with seed UACAGUA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-101-3p.2
|
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_59189545 Show fit | 0.50 |
ENST00000340635.6
|
phosphodiesterase 4D, cAMP-specific |
|
| chr15_+_52311398 Show fit | 0.44 |
ENST00000261845.5
|
mitogen-activated protein kinase 6 |
|
| chr2_+_118846008 Show fit | 0.39 |
ENST00000245787.4
|
insulin induced gene 2 |
|
| chr2_+_46926048 Show fit | 0.38 |
ENST00000306503.5
|
suppressor of cytokine signaling 5 |
|
| chr18_-_19180681 Show fit | 0.36 |
ENST00000269214.5
|
establishment of sister chromatid cohesion N-acetyltransferase 1 |
|
| chr3_+_88188254 Show fit | 0.32 |
ENST00000309495.5
|
zinc finger protein 654 |
|
| chr14_-_53162361 Show fit | 0.32 |
ENST00000395686.3
|
ERO1-like (S. cerevisiae) |
|
| chr2_+_198380289 Show fit | 0.30 |
ENST00000233892.4
ENST00000409916.1 |
MOB family member 4, phocein |
|
| chr1_-_85156216 Show fit | 0.30 |
ENST00000342203.3
ENST00000370612.4 |
synovial sarcoma, X breakpoint 2 interacting protein |
|
| chr2_+_201676256 Show fit | 0.30 |
ENST00000452206.1
ENST00000410110.2 ENST00000409600.1 |
basic leucine zipper and W2 domains 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UACAGUA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 0.4 | GO:0090325 | regulation of locomotion involved in locomotory behavior(GO:0090325) |
| 0.1 | 0.4 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.0 | 0.4 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 0.4 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.0 | 0.4 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.1 | 0.3 | GO:0002071 | glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560) |
| 0.0 | 0.3 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.0 | 0.3 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 0.3 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.4 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 0.4 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.4 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 0.3 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 0.3 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.3 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.0 | 0.2 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.0 | 0.2 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.0 | 0.2 | GO:0031905 | early endosome lumen(GO:0031905) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 0.3 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 0.3 | GO:0050473 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.0 | 0.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.3 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.2 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.1 | 0.2 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.0 | 0.2 | GO:0005287 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.0 | 0.2 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.3 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.0 | 0.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.0 | 0.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.0 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |