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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TLX1_NFIC

Z-value: 1.86

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Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
ENSG00000107807.8 T cell leukemia homeobox 1
ENSG00000141905.13 nuclear factor I C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFIChg19_v2_chr19_+_3359561_33596810.355.0e-01Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_33663474 2.23 ENST00000594414.1
SBP1; Uncharacterized protein
chr15_+_63682335 1.13 ENST00000559379.1
ENST00000559821.1
RP11-321G12.1
chr19_+_10397648 1.10 ENST00000340992.4
ENST00000393717.2
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr11_-_64764435 1.08 ENST00000534177.1
ENST00000301887.4
basic leucine zipper transcription factor, ATF-like 2
chr1_-_41950342 1.03 ENST00000372587.4
endothelin 2
chr21_+_33784670 0.90 ENST00000300255.2
eva-1 homolog C (C. elegans)
chr22_+_46449674 0.86 ENST00000381051.2
hsa-mir-4763
chr4_+_66536248 0.81 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr19_+_10397621 0.80 ENST00000380770.3
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chrX_-_40005865 0.80 ENST00000412952.1
BCL6 corepressor
chr2_+_27071292 0.76 ENST00000431402.1
ENST00000434719.1
dihydropyrimidinase-like 5
chr4_+_86749045 0.76 ENST00000514229.1
Rho GTPase activating protein 24
chr3_-_131736593 0.75 ENST00000514999.1
copine IV
chr21_+_33784957 0.71 ENST00000401402.3
ENST00000382699.3
eva-1 homolog C (C. elegans)
chrX_-_128788914 0.69 ENST00000429967.1
ENST00000307484.6
apelin
chr7_+_22766766 0.67 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
interleukin 6 (interferon, beta 2)
chr6_-_31745085 0.66 ENST00000375686.3
ENST00000447450.1
von Willebrand factor A domain containing 7
chrX_+_2746818 0.65 ENST00000398806.3
glycogenin 2
chr1_+_84767289 0.59 ENST00000394834.3
ENST00000370669.1
sterile alpha motif domain containing 13
chr1_-_200992827 0.58 ENST00000332129.2
ENST00000422435.2
kinesin family member 21B
chr11_+_107992518 0.58 ENST00000527942.1
acetyl-CoA acetyltransferase 1
chr15_+_89182178 0.57 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr5_-_111093081 0.55 ENST00000453526.2
ENST00000509427.1
neuronal regeneration related protein
chr19_-_10628098 0.53 ENST00000590601.1
sphingosine-1-phosphate receptor 5
chr9_+_139871948 0.52 ENST00000224167.2
ENST00000457950.1
ENST00000371625.3
ENST00000371623.3
prostaglandin D2 synthase 21kDa (brain)
chr1_+_79115503 0.51 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr15_+_89182156 0.50 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr6_+_29555683 0.49 ENST00000383640.2
olfactory receptor, family 2, subfamily H, member 2
chr6_-_31745037 0.49 ENST00000375688.4
von Willebrand factor A domain containing 7
chr1_+_110453608 0.49 ENST00000369801.1
colony stimulating factor 1 (macrophage)
chr3_-_131756559 0.48 ENST00000505957.1
copine IV
chr14_-_105071083 0.47 ENST00000415614.2
transmembrane protein 179
chr16_-_51185149 0.47 ENST00000566102.1
ENST00000541611.1
spalt-like transcription factor 1
chr22_-_30960876 0.46 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
galactose-3-O-sulfotransferase 1
chr7_-_150652924 0.46 ENST00000330883.4
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_+_219187871 0.45 ENST00000258362.3
paroxysmal nonkinesigenic dyskinesia
chr16_-_19896150 0.44 ENST00000570142.1
G protein-coupled receptor, family C, group 5, member B
chrX_+_2746850 0.44 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
glycogenin 2
chr11_+_74862032 0.44 ENST00000289575.5
ENST00000341411.4
solute carrier organic anion transporter family, member 2B1
chr17_+_77030267 0.44 ENST00000581774.1
C1q and tumor necrosis factor related protein 1
chr11_+_74862140 0.44 ENST00000525650.1
ENST00000454962.2
solute carrier organic anion transporter family, member 2B1
chr7_-_100239132 0.43 ENST00000223051.3
ENST00000431692.1
transferrin receptor 2
chr1_+_113217309 0.42 ENST00000544796.1
ENST00000369644.1
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr20_-_44519839 0.41 ENST00000372518.4
neuralized E3 ubiquitin protein ligase 2
chr1_-_160854953 0.41 ENST00000326245.3
intelectin 1 (galactofuranose binding)
chr15_+_36994210 0.40 ENST00000562489.1
chromosome 15 open reading frame 41
chr11_+_34663913 0.40 ENST00000532302.1
ets homologous factor
chr1_+_95975672 0.40 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
chr12_+_66218212 0.39 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
high mobility group AT-hook 2
chr12_-_56105880 0.39 ENST00000557257.1
integrin, alpha 7
chr6_-_43595039 0.39 ENST00000307114.7
GTP binding protein 2
chr17_+_27369918 0.39 ENST00000323372.4
pipecolic acid oxidase
chr3_-_188665428 0.38 ENST00000444488.1
TPRG1 antisense RNA 1
chrX_-_154376044 0.37 ENST00000362018.2
mature T-cell proliferation 1
chr1_+_79086088 0.36 ENST00000370751.5
ENST00000342282.3
interferon-induced protein 44-like
chr1_+_110453203 0.36 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr18_-_74728998 0.36 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
myelin basic protein
chr11_+_64004888 0.35 ENST00000541681.1
vascular endothelial growth factor B
chr1_+_65775204 0.34 ENST00000371069.4
DnaJ (Hsp40) homolog, subfamily C, member 6
chr7_-_37024665 0.33 ENST00000396040.2
engulfment and cell motility 1
chr16_-_3285049 0.33 ENST00000575948.1
zinc finger protein 200
chr5_+_150020240 0.33 ENST00000519664.1
synaptopodin
chr19_-_35454953 0.33 ENST00000404801.1
zinc finger protein 792
chr17_+_79369249 0.33 ENST00000574717.2
Uncharacterized protein
chr21_+_17792672 0.33 ENST00000602620.1
long intergenic non-protein coding RNA 478
chr1_-_243418650 0.32 ENST00000522995.1
centrosomal protein 170kDa
chr17_+_48503603 0.32 ENST00000502667.1
acyl-CoA synthetase family member 2
chr5_+_92919043 0.32 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr22_+_19706958 0.32 ENST00000395109.2
septin 5
chr9_+_129097479 0.32 ENST00000402437.2
multivesicular body subunit 12B
chr7_-_100076873 0.31 ENST00000300181.2
TSC22 domain family, member 4
chr12_+_13349711 0.31 ENST00000538364.1
ENST00000396301.3
epithelial membrane protein 1
chr12_-_52585765 0.31 ENST00000313234.5
ENST00000394815.2
keratin 80
chr17_+_74372662 0.31 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr17_+_48503519 0.31 ENST00000300441.4
ENST00000541920.1
ENST00000506582.1
ENST00000504392.1
ENST00000427954.2
acyl-CoA synthetase family member 2
chr1_-_151345159 0.31 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
selenium binding protein 1
chr7_-_100076765 0.31 ENST00000393991.1
TSC22 domain family, member 4
chr2_+_27071045 0.31 ENST00000401478.1
dihydropyrimidinase-like 5
chr19_-_59010565 0.30 ENST00000594786.1
solute carrier family 27 (fatty acid transporter), member 5
chr8_-_80680078 0.30 ENST00000337919.5
ENST00000354724.3
hes-related family bHLH transcription factor with YRPW motif 1
chr8_-_141728444 0.30 ENST00000521562.1
protein tyrosine kinase 2
chr20_-_60942326 0.30 ENST00000370677.3
ENST00000370692.3
laminin, alpha 5
chr5_-_176923803 0.30 ENST00000506161.1
PDZ and LIM domain 7 (enigma)
chr7_+_143078652 0.30 ENST00000354434.4
ENST00000449423.2
zyxin
chr2_-_192711968 0.30 ENST00000304141.4
serum deprivation response
chr4_+_110834033 0.29 ENST00000509793.1
ENST00000265171.5
epidermal growth factor
chr1_-_242612726 0.29 ENST00000459864.1
phospholipase D family, member 5
chr7_-_5463175 0.29 ENST00000399537.4
ENST00000430969.1
trinucleotide repeat containing 18
chr19_+_3708376 0.29 ENST00000539908.2
tight junction protein 3
chr16_-_51185172 0.29 ENST00000251020.4
spalt-like transcription factor 1
chr14_+_69951457 0.28 ENST00000322564.7
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr19_+_45312310 0.28 ENST00000589651.1
basal cell adhesion molecule (Lutheran blood group)
chr20_+_33759854 0.28 ENST00000216968.4
protein C receptor, endothelial
chr15_-_40633101 0.28 ENST00000559313.1
chromosome 15 open reading frame 52
chrX_+_49126294 0.28 ENST00000466508.1
ENST00000438316.1
ENST00000055335.6
ENST00000495799.1
protein phosphatase 1, regulatory subunit 3F
chr8_-_42065187 0.27 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
plasminogen activator, tissue
chr1_-_16539094 0.27 ENST00000270747.3
Rho guanine nucleotide exchange factor (GEF) 19
chr1_+_110453462 0.26 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chrX_+_47083037 0.26 ENST00000523034.1
cyclin-dependent kinase 16
chr19_-_41388657 0.26 ENST00000301146.4
ENST00000291764.3
cytochrome P450, family 2, subfamily A, polypeptide 7
chr15_+_90735145 0.26 ENST00000559792.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr7_-_7575477 0.26 ENST00000399429.3
collagen, type XXVIII, alpha 1
chr6_-_53013620 0.26 ENST00000259803.7
glial cells missing homolog 1 (Drosophila)
chr20_+_61299155 0.25 ENST00000451793.1
solute carrier organic anion transporter family, member 4A1
chr12_-_54813229 0.25 ENST00000293379.4
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_57089671 0.25 ENST00000532437.1
tankyrase 1 binding protein 1, 182kDa
chr8_-_21988558 0.25 ENST00000312841.8
hair growth associated
chr3_+_46742823 0.25 ENST00000326431.3
transmembrane inner ear
chr16_-_19896220 0.25 ENST00000562469.1
ENST00000300571.2
G protein-coupled receptor, family C, group 5, member B
chr11_-_65149422 0.24 ENST00000526432.1
ENST00000527174.1
solute carrier family 25, member 45
chr6_-_28321971 0.24 ENST00000396838.2
ENST00000426434.1
ENST00000434036.1
ENST00000439628.1
zinc finger and SCAN domain containing 31
chr17_-_42994283 0.24 ENST00000593179.1
glial fibrillary acidic protein
chr10_+_102758105 0.23 ENST00000429732.1
leucine zipper, putative tumor suppressor 2
chr8_+_104384616 0.23 ENST00000520337.1
collagen triple helix repeat containing 1
chr16_+_30662184 0.23 ENST00000300835.4
proline rich 14
chr1_+_220960033 0.23 ENST00000366910.5
mitochondrial amidoxime reducing component 1
chr12_-_56106060 0.23 ENST00000452168.2
integrin, alpha 7
chr19_-_33716750 0.22 ENST00000253188.4
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
chr17_-_982198 0.22 ENST00000571945.1
ENST00000536794.2
active BCR-related
chr6_-_28321909 0.22 ENST00000446222.1
zinc finger and SCAN domain containing 31
chr5_-_176923846 0.22 ENST00000506537.1
PDZ and LIM domain 7 (enigma)
chr7_-_27187393 0.22 ENST00000222728.3
homeobox A6
chr1_+_36621174 0.22 ENST00000429533.2
MAP7 domain containing 1
chr1_+_12538594 0.22 ENST00000543710.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr8_-_22014339 0.22 ENST00000306317.2
leucine-rich repeat LGI family, member 3
chr20_-_50722183 0.22 ENST00000371523.4
ZFP64 zinc finger protein
chr7_+_143079000 0.22 ENST00000392910.2
zyxin
chr19_-_6737576 0.22 ENST00000601716.1
ENST00000264080.7
G protein-coupled receptor 108
chr17_+_19314505 0.22 ENST00000461366.1
ring finger protein 112
chr19_+_45312347 0.22 ENST00000270233.6
ENST00000591520.1
basal cell adhesion molecule (Lutheran blood group)
chr1_-_32264250 0.22 ENST00000528579.1
SPOC domain containing 1
chr11_+_74862100 0.22 ENST00000532236.1
ENST00000531756.1
solute carrier organic anion transporter family, member 2B1
chr15_+_89181974 0.22 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr1_+_113217043 0.21 ENST00000413052.2
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_-_27816556 0.21 ENST00000536657.1
WAS protein family, member 2
chr1_+_113217073 0.21 ENST00000369645.1
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_+_18417948 0.21 ENST00000542179.1
lactate dehydrogenase A
chr17_-_26903900 0.21 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
aldolase C, fructose-bisphosphate
chr7_+_116165038 0.21 ENST00000393470.1
caveolin 1, caveolae protein, 22kDa
chr14_+_75746781 0.21 ENST00000555347.1
FBJ murine osteosarcoma viral oncogene homolog
chr17_+_38599693 0.21 ENST00000542955.1
ENST00000269593.4
insulin-like growth factor binding protein 4
chr9_+_129097520 0.20 ENST00000436593.3
multivesicular body subunit 12B
chr3_-_53880401 0.20 ENST00000315251.6
choline dehydrogenase
chr5_+_150020214 0.20 ENST00000307662.4
synaptopodin
chr15_-_72523924 0.20 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
pyruvate kinase, muscle
chr12_+_48513009 0.19 ENST00000359794.5
ENST00000551339.1
ENST00000395233.2
ENST00000548345.1
phosphofructokinase, muscle
chr9_+_35673853 0.19 ENST00000378357.4
carbonic anhydrase IX
chr8_+_38243821 0.19 ENST00000519476.2
leucine zipper-EF-hand containing transmembrane protein 2
chr19_-_8675559 0.19 ENST00000597188.1
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr9_-_139915246 0.18 ENST00000470535.1
ATP-binding cassette, sub-family A (ABC1), member 2
chr6_-_39197226 0.18 ENST00000359534.3
potassium channel, subfamily K, member 5
chr1_+_206137237 0.18 ENST00000468509.1
ENST00000367129.2
family with sequence similarity 72, member A
chr16_+_30662050 0.18 ENST00000568754.1
proline rich 14
chrX_+_102631248 0.18 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr17_+_37894570 0.18 ENST00000394211.3
growth factor receptor-bound protein 7
chr1_-_166136187 0.18 ENST00000338353.3
family with sequence similarity 78, member B
chr2_+_27070964 0.18 ENST00000288699.6
dihydropyrimidinase-like 5
chr1_+_113217345 0.18 ENST00000357443.2
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_-_166135952 0.17 ENST00000354422.3
family with sequence similarity 78, member B
chr1_+_110453514 0.17 ENST00000369802.3
ENST00000420111.2
colony stimulating factor 1 (macrophage)
chr15_-_40213080 0.17 ENST00000561100.1
G protein-coupled receptor 176
chr8_-_141728760 0.17 ENST00000430260.2
protein tyrosine kinase 2
chr1_+_9648921 0.17 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
transmembrane protein 201
chr17_-_4806369 0.17 ENST00000293780.4
cholinergic receptor, nicotinic, epsilon (muscle)
chr19_-_42927251 0.17 ENST00000597001.1
lipase, hormone-sensitive
chr20_-_60942361 0.16 ENST00000252999.3
laminin, alpha 5
chr2_+_74229812 0.16 ENST00000305799.7
tet methylcytosine dioxygenase 3
chr19_-_45748628 0.16 ENST00000590022.1
AC006126.4
chr12_+_21168630 0.16 ENST00000421593.2
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr19_+_40871734 0.16 ENST00000359274.5
phospholipase D family, member 3
chr10_-_100174900 0.15 ENST00000370575.4
pyridine nucleotide-disulphide oxidoreductase domain 2
chr1_+_101003687 0.15 ENST00000315033.4
G protein-coupled receptor 88
chr11_-_118789613 0.15 ENST00000532899.1
B-cell CLL/lymphoma 9-like
chr1_+_39456895 0.15 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr19_-_12946215 0.15 ENST00000591512.1
ENST00000587549.1
ENST00000322912.5
retbindin
chr19_+_38664224 0.15 ENST00000601054.1
signal-induced proliferation-associated 1 like 3
chr11_-_71752100 0.15 ENST00000542977.1
nuclear mitotic apparatus protein 1
chr7_+_102553430 0.15 ENST00000339431.4
ENST00000249377.4
leucine rich repeat containing 17
chr9_-_25678856 0.15 ENST00000358022.3
tumor suppressor candidate 1
chr19_+_36157715 0.15 ENST00000379013.2
ENST00000222275.2
uroplakin 1A
chr2_+_234296792 0.15 ENST00000409813.3
diacylglycerol kinase, delta 130kDa
chr19_+_1491144 0.15 ENST00000233596.3
receptor accessory protein 6
chr12_+_48513570 0.15 ENST00000551804.1
phosphofructokinase, muscle
chr7_-_1595107 0.15 ENST00000414730.1
transmembrane protein 184A
chr1_+_19967014 0.15 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr2_+_220325977 0.15 ENST00000396686.1
ENST00000396689.2
SPEG complex locus
chr3_-_112356944 0.14 ENST00000461431.1
coiled-coil domain containing 80
chr17_-_48474828 0.14 ENST00000576448.1
ENST00000225972.7
leucine rich repeat containing 59
chrX_-_54522558 0.14 ENST00000375135.3
FYVE, RhoGEF and PH domain containing 1
chr19_-_36247910 0.14 ENST00000587965.1
ENST00000004982.3
heat shock protein, alpha-crystallin-related, B6
chr10_+_22614547 0.14 ENST00000416820.1
BMI1 polycomb ring finger oncogene
chr17_+_7792101 0.14 ENST00000358181.4
ENST00000330494.7
chromodomain helicase DNA binding protein 3
chr8_-_22014255 0.14 ENST00000424267.2
leucine-rich repeat LGI family, member 3
chr3_-_13028536 0.14 ENST00000450726.1
IQ motif and Sec7 domain 1
chrX_-_57163430 0.14 ENST00000374908.1
spindlin family, member 2A
chr15_+_71228826 0.14 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
leucine rich repeat containing 49
chr1_-_229569834 0.14 ENST00000366684.3
ENST00000366683.2
actin, alpha 1, skeletal muscle
chr10_+_129785574 0.14 ENST00000430713.2
ENST00000471218.1
protein tyrosine phosphatase, receptor type, E
chr1_-_242612779 0.14 ENST00000427495.1
phospholipase D family, member 5
chr19_+_50380682 0.14 ENST00000221543.5
TBC1 domain family, member 17

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.3 1.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 1.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 0.8 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.2 0.7 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.2 0.7 GO:1990637 response to prolactin(GO:1990637)
0.2 0.5 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.4 GO:0046356 acetyl-CoA catabolic process(GO:0046356)
0.1 0.8 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 1.0 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.5 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 0.3 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.5 GO:0019075 virus maturation(GO:0019075)
0.1 0.4 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.4 GO:0009624 response to nematode(GO:0009624)
0.1 0.2 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 0.3 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 0.4 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.2 GO:1903248 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1 0.3 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.1 0.4 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.5 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.2 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.1 0.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.2 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.3 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.4 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0061743 motor learning(GO:0061743)
0.0 1.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 1.0 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.2 GO:0042126 nitrate metabolic process(GO:0042126)
0.0 0.2 GO:0090402 senescence-associated heterochromatin focus assembly(GO:0035986) oncogene-induced cell senescence(GO:0090402)
0.0 0.3 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 1.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.4 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:1902462 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.1 GO:1902715 secretory granule localization(GO:0032252) positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.1 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.1 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.4 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.1 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.3 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.3 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.0 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.1 GO:0072752 cellular response to rapamycin(GO:0072752)
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.3 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) regulation of resting membrane potential(GO:0060075)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0044856 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.5 GO:0007618 mating(GO:0007618)
0.0 0.1 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.8 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 0.5 GO:0097444 spine apparatus(GO:0097444)
0.1 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.5 GO:0043260 laminin-11 complex(GO:0043260)
0.1 0.5 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.3 GO:1902912 pyruvate kinase complex(GO:1902912)
0.1 0.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.8 GO:0010369 chromocenter(GO:0010369)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.3 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 1.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 1.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.2 1.0 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.4 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2 0.5 GO:0005055 laminin receptor activity(GO:0005055)
0.1 0.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.4 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.4 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.2 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 0.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.1 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.1 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.0 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:1902444 riboflavin binding(GO:1902444)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.8 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis