ISMARA results: TLX1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TLX1_NFIC

Z-value: 1.86

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Transcription factors associated with TLX1_NFIC

Gene Symbol	Gene ID	Gene Info
TLX1 Ensembl NCBI GeneCards UniProt	ENSG00000107807.8	T cell leukemia homeobox 1
NFIC Ensembl NCBI GeneCards UniProt	ENSG00000141905.13	nuclear factor I C

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIC	hg19_v2_chr19_+_3359561_3359681	0.35	5.0e-01	Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_33663474 Show fit	2.23	ENST00000594414.1	SBP1 Ensembl NCBI GeneCards UniProt Show fit	SBP1; Uncharacterized protein
chr15_+_63682335 Show fit	1.13	ENST00000559379.1 ENST00000559821.1	RP11-321G12.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-321G12.1
chr19_+_10397648 Show fit	1.10	ENST00000340992.4 ENST00000393717.2	ICAM4 Ensembl NCBI GeneCards UniProt Show fit	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr11_-_64764435 Show fit	1.08	ENST00000534177.1 ENST00000301887.4	BATF2 Ensembl NCBI GeneCards UniProt Show fit	basic leucine zipper transcription factor, ATF-like 2
chr1_-_41950342 Show fit	1.03	ENST00000372587.4	EDN2 Ensembl NCBI GeneCards UniProt Show fit	endothelin 2
chr21_+_33784670 Show fit	0.90	ENST00000300255.2	EVA1C Ensembl NCBI GeneCards UniProt Show fit	eva-1 homolog C (C. elegans)
chr22_+_46449674 Show fit	0.86	ENST00000381051.2	FLJ27365 Ensembl NCBI GeneCards UniProt Show fit	hsa-mir-4763
chr4_+_66536248 Show fit	0.81	ENST00000514260.1 ENST00000507117.1	RP11-807H7.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-807H7.1
chr19_+_10397621 Show fit	0.80	ENST00000380770.3	ICAM4 Ensembl NCBI GeneCards UniProt Show fit	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chrX_-_40005865 Show fit	0.80	ENST00000412952.1	BCOR Ensembl NCBI GeneCards UniProt Show fit	BCL6 corepressor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.3	1.4	GO:1904141	mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.3	1.3	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.0	1.2	GO:0005980	glycogen catabolic process(GO:0005980)
0.3	1.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1	1.0	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	1.0	GO:0042832	defense response to protozoan(GO:0042832)
0.2	0.8	GO:0000415	negative regulation of histone H3-K36 methylation(GO:0000415)
0.1	0.8	GO:0061034	olfactory bulb mitral cell layer development(GO:0061034)
0.0	0.8	GO:0035987	endodermal cell differentiation(GO:0035987)

Showing 1 to 10 of 109 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0015030	Cajal body(GO:0015030)
0.2	1.4	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.0	0.8	GO:0010369	chromocenter(GO:0010369)
0.1	0.6	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.2	0.5	GO:0097444	spine apparatus(GO:0097444)
0.1	0.5	GO:0043260	laminin-11 complex(GO:0043260)
0.1	0.5	GO:1902937	inward rectifier potassium channel complex(GO:1902937)
0.0	0.5	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.4	GO:0033269	internode region of axon(GO:0033269)
0.0	0.4	GO:1990712	HFE-transferrin receptor complex(GO:1990712)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.4	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4	1.3	GO:0008859	exoribonuclease II activity(GO:0008859)
0.1	1.3	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.2	1.1	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.2	1.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	0.7	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.7	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.1	0.6	GO:0003996	acyl-CoA ligase activity(GO:0003996)
0.1	0.6	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.2	0.5	GO:0005055	laminin receptor activity(GO:0005055)

Showing 1 to 10 of 65 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.8	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.1	PID ENDOTHELIN PATHWAY	Endothelins
0.9	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.7	ST STAT3 PATHWAY	STAT3 Pathway
0.7	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.7	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.6	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	1.3	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	1.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	1.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.8	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.6	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.5	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism

Showing 1 to 10 of 15 entries

Results for TLX1_NFIC

Z-value: 1.86

Motif logo

Transcription factors associated with TLX1_NFIC

Activity-expression correlation:

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: