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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for THRA_RXRB

Z-value: 0.84

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Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
THRA
ENSG00000126351.8 thyroid hormone receptor alpha
RXRB
ENSG00000204231.6 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRAhg19_v2_chr17_+_38219063_38219154-0.862.9e-02Click!
RXRBhg19_v2_chr6_-_33168391_33168465-0.611.9e-01Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_150693318 1.26 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1
HORMA domain containing 1
chr1_-_150693305 0.72 ENST00000368987.1
HORMAD1
HORMA domain containing 1
chr5_+_162887556 0.63 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chr12_+_102514019 0.60 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr12_+_102513950 0.56 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr6_+_151358048 0.52 ENST00000450635.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr9_-_33402506 0.48 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr8_-_99954788 0.48 ENST00000523601.1
STK3
serine/threonine kinase 3
chr12_+_41221975 0.47 ENST00000552913.1
CNTN1
contactin 1
chr2_-_55459437 0.47 ENST00000401408.1
CLHC1
clathrin heavy chain linker domain containing 1
chr14_-_58893832 0.46 ENST00000556007.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr14_+_21492331 0.45 ENST00000533984.1
ENST00000532213.2
AL161668.5
AL161668.5
chr15_-_45422056 0.44 ENST00000267803.4
ENST00000559014.1
ENST00000558851.1
ENST00000559988.1
ENST00000558996.1
ENST00000558422.1
ENST00000559226.1
ENST00000558326.1
ENST00000558377.1
ENST00000559644.1
DUOXA1
dual oxidase maturation factor 1
chr2_-_55459294 0.44 ENST00000407122.1
ENST00000406437.2
CLHC1
clathrin heavy chain linker domain containing 1
chr3_+_164924716 0.39 ENST00000470138.1
ENST00000498616.1
RP11-85M11.2
RP11-85M11.2
chr1_+_25071848 0.37 ENST00000374379.4
CLIC4
chloride intracellular channel 4
chr6_-_89673280 0.37 ENST00000369475.3
ENST00000369485.4
ENST00000538899.1
ENST00000265607.6
RNGTT
RNA guanylyltransferase and 5'-phosphatase
chr6_+_35773070 0.37 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chr5_-_145483932 0.36 ENST00000311450.4
PLAC8L1
PLAC8-like 1
chr12_+_41221794 0.33 ENST00000547849.1
CNTN1
contactin 1
chr2_+_230787201 0.33 ENST00000283946.3
FBXO36
F-box protein 36
chr1_-_242612726 0.33 ENST00000459864.1
PLD5
phospholipase D family, member 5
chr1_+_196621002 0.32 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr1_-_205719295 0.32 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr22_-_29137771 0.31 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr14_-_58893876 0.30 ENST00000555097.1
ENST00000555404.1
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr19_+_49109990 0.29 ENST00000321762.1
SPACA4
sperm acrosome associated 4
chr1_+_196621156 0.29 ENST00000359637.2
CFH
complement factor H
chr12_-_88535747 0.29 ENST00000309041.7
CEP290
centrosomal protein 290kDa
chr6_-_150039249 0.27 ENST00000543571.1
LATS1
large tumor suppressor kinase 1
chr16_+_85942594 0.27 ENST00000566369.1
IRF8
interferon regulatory factor 8
chr13_+_76123883 0.26 ENST00000377595.3
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr19_-_56047661 0.26 ENST00000344158.3
SBK2
SH3 domain binding kinase family, member 2
chr22_+_17082732 0.25 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1
transmembrane phosphatase with tensin homology pseudogene 1
chr6_+_64346386 0.25 ENST00000509330.1
PHF3
PHD finger protein 3
chr2_-_179315786 0.25 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr1_+_178482262 0.24 ENST00000367641.3
ENST00000367639.1
TEX35
testis expressed 35
chr11_-_73720122 0.24 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr15_+_48413211 0.24 ENST00000449382.2
SLC24A5
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
chr9_-_114246332 0.24 ENST00000602978.1
KIAA0368
KIAA0368
chr2_-_179315490 0.24 ENST00000487082.1
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr2_-_179315453 0.22 ENST00000432031.2
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr12_+_56477093 0.22 ENST00000549672.1
ENST00000415288.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr6_-_150039170 0.22 ENST00000458696.2
ENST00000392273.3
LATS1
large tumor suppressor kinase 1
chr15_+_48413169 0.22 ENST00000341459.3
ENST00000482911.2
SLC24A5
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
chr14_+_88852059 0.22 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr14_-_102552659 0.22 ENST00000441629.2
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr14_-_55369525 0.21 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GCH1
GTP cyclohydrolase 1
chr7_-_95064264 0.20 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
PON2
paraoxonase 2
chr16_-_58328923 0.20 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
PRSS54
protease, serine, 54
chr3_+_179322481 0.20 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr22_+_23243156 0.20 ENST00000390323.2
IGLC2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr8_+_27632083 0.20 ENST00000519637.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr4_+_177241094 0.20 ENST00000503362.1
SPCS3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr16_-_58328870 0.19 ENST00000543437.1
PRSS54
protease, serine, 54
chr14_+_58765103 0.19 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr17_-_7082668 0.19 ENST00000573083.1
ENST00000574388.1
ASGR1
asialoglycoprotein receptor 1
chr4_+_26321284 0.19 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr6_+_41196052 0.19 ENST00000341495.2
TREML4
triggering receptor expressed on myeloid cells-like 4
chr17_+_58499844 0.19 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr3_+_14989186 0.19 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr14_+_71788096 0.19 ENST00000557151.1
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr11_-_17565854 0.18 ENST00000005226.7
USH1C
Usher syndrome 1C (autosomal recessive, severe)
chr6_+_30130969 0.18 ENST00000376694.4
TRIM15
tripartite motif containing 15
chr16_-_29757272 0.18 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chr11_-_65837090 0.18 ENST00000529036.1
RP11-1167A19.2
Uncharacterized protein
chr13_+_41635617 0.18 ENST00000542082.1
WBP4
WW domain binding protein 4
chr2_+_230787213 0.18 ENST00000409992.1
FBXO36
F-box protein 36
chr16_-_58328884 0.18 ENST00000569079.1
PRSS54
protease, serine, 54
chr20_+_56884752 0.18 ENST00000244040.3
RAB22A
RAB22A, member RAS oncogene family
chr3_-_98241760 0.17 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1
claudin domain containing 1
chr12_-_102513843 0.17 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr18_-_19748379 0.17 ENST00000579431.1
GATA6-AS1
GATA6 antisense RNA 1 (head to head)
chr12_+_20963647 0.17 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr3_-_45957088 0.17 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr2_-_192016276 0.17 ENST00000413064.1
STAT4
signal transducer and activator of transcription 4
chr1_-_27240455 0.17 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr15_-_51914996 0.17 ENST00000251076.5
DMXL2
Dmx-like 2
chr2_-_61389240 0.16 ENST00000606876.1
RP11-493E12.1
RP11-493E12.1
chr2_+_55459808 0.16 ENST00000404735.1
RPS27A
ribosomal protein S27a
chr2_-_230786679 0.16 ENST00000543084.1
ENST00000343290.5
ENST00000389044.4
ENST00000283943.5
TRIP12
thyroid hormone receptor interactor 12
chr4_+_26322409 0.16 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr1_-_91487770 0.16 ENST00000337393.5
ZNF644
zinc finger protein 644
chr1_-_85156216 0.16 ENST00000342203.3
ENST00000370612.4
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr21_+_34697258 0.16 ENST00000442071.1
ENST00000442357.2
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr19_-_55874611 0.16 ENST00000424985.3
FAM71E2
family with sequence similarity 71, member E2
chr12_-_80328949 0.16 ENST00000450142.2
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr7_+_5085452 0.15 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr2_+_85661918 0.15 ENST00000340326.2
SH2D6
SH2 domain containing 6
chr14_-_82000140 0.15 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr7_-_108097144 0.15 ENST00000418239.1
NRCAM
neuronal cell adhesion molecule
chr3_-_179322416 0.15 ENST00000259038.2
MRPL47
mitochondrial ribosomal protein L47
chr17_-_41132088 0.15 ENST00000591916.1
ENST00000451885.2
ENST00000454303.1
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr10_+_26986582 0.14 ENST00000376215.5
ENST00000376203.5
PDSS1
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr11_-_118661828 0.14 ENST00000264018.4
DDX6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr14_+_58765305 0.14 ENST00000445108.1
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr11_-_73720276 0.14 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr5_+_145583156 0.14 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr8_+_104033296 0.14 ENST00000521514.1
ENST00000518738.1
ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr18_-_268019 0.14 ENST00000261600.6
THOC1
THO complex 1
chr17_-_38821373 0.14 ENST00000394052.3
KRT222
keratin 222
chr19_+_32836499 0.14 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr1_-_203144941 0.14 ENST00000255416.4
MYBPH
myosin binding protein H
chr9_-_72374848 0.14 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr3_+_87276407 0.14 ENST00000471660.1
ENST00000263780.4
ENST00000494980.1
CHMP2B
charged multivesicular body protein 2B
chr14_+_57857262 0.14 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr7_+_94536514 0.14 ENST00000413325.1
PPP1R9A
protein phosphatase 1, regulatory subunit 9A
chr3_-_179322436 0.14 ENST00000392659.2
ENST00000476781.1
MRPL47
mitochondrial ribosomal protein L47
chr22_-_30661807 0.14 ENST00000403389.1
OSM
oncostatin M
chr2_+_55459495 0.14 ENST00000272317.6
ENST00000449323.1
RPS27A
ribosomal protein S27a
chr6_+_139456226 0.14 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chr22_-_20138302 0.13 ENST00000540078.1
ENST00000439765.2
AC006547.14
uncharacterized protein LOC388849
chr12_+_20963632 0.13 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr11_-_62437486 0.13 ENST00000528115.1
C11orf48
chromosome 11 open reading frame 48
chrX_+_114827818 0.13 ENST00000420625.2
PLS3
plastin 3
chr2_+_228190066 0.13 ENST00000436237.1
ENST00000443428.2
ENST00000418961.1
MFF
mitochondrial fission factor
chr3_-_47205066 0.13 ENST00000412450.1
SETD2
SET domain containing 2
chr17_+_60457914 0.13 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr8_-_53626974 0.13 ENST00000435644.2
ENST00000518710.1
ENST00000025008.5
ENST00000517963.1
RB1CC1
RB1-inducible coiled-coil 1
chr8_-_42698292 0.13 ENST00000529779.1
THAP1
THAP domain containing, apoptosis associated protein 1
chr12_+_27849378 0.13 ENST00000310791.2
REP15
RAB15 effector protein
chr7_+_94536898 0.13 ENST00000433360.1
ENST00000340694.4
ENST00000424654.1
PPP1R9A
protein phosphatase 1, regulatory subunit 9A
chr17_+_48046671 0.13 ENST00000505318.2
DLX4
distal-less homeobox 4
chr2_+_65663812 0.12 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
AC074391.1
chr9_+_36572851 0.12 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr1_-_85040090 0.12 ENST00000370630.5
CTBS
chitobiase, di-N-acetyl-
chr4_+_26165074 0.12 ENST00000512351.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr2_-_230786619 0.12 ENST00000389045.3
ENST00000409677.1
TRIP12
thyroid hormone receptor interactor 12
chr10_+_64893039 0.12 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chr5_+_112849373 0.12 ENST00000161863.4
ENST00000515883.1
YTHDC2
YTH domain containing 2
chr2_+_219745020 0.12 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chr12_+_95611569 0.12 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
VEZT
vezatin, adherens junctions transmembrane protein
chr17_-_58499766 0.12 ENST00000588898.1
USP32
ubiquitin specific peptidase 32
chr8_+_27632047 0.12 ENST00000397418.2
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr8_+_63161550 0.12 ENST00000328472.5
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr9_+_131452239 0.12 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr2_-_165698662 0.12 ENST00000194871.6
ENST00000445474.2
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr3_+_179322573 0.11 ENST00000493866.1
ENST00000472629.1
ENST00000482604.1
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr6_+_41196077 0.11 ENST00000448827.2
TREML4
triggering receptor expressed on myeloid cells-like 4
chr14_-_31889782 0.11 ENST00000543095.2
HEATR5A
HEAT repeat containing 5A
chr5_+_66124590 0.11 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_82165350 0.11 ENST00000359929.3
LPHN2
latrophilin 2
chr1_+_70876926 0.11 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr14_+_88851874 0.11 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chr19_+_57862622 0.11 ENST00000391705.3
ENST00000443917.2
ENST00000598744.1
ZNF304
zinc finger protein 304
chr1_-_173886491 0.11 ENST00000367698.3
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_114827851 0.11 ENST00000539310.1
PLS3
plastin 3
chr3_-_98241713 0.10 ENST00000502288.1
ENST00000512147.1
ENST00000510541.1
ENST00000503621.1
ENST00000511081.1
CLDND1
claudin domain containing 1
chrX_+_67913471 0.10 ENST00000374597.3
STARD8
StAR-related lipid transfer (START) domain containing 8
chr6_-_31745037 0.10 ENST00000375688.4
VWA7
von Willebrand factor A domain containing 7
chr5_+_145583107 0.10 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr15_-_34630234 0.10 ENST00000558667.1
ENST00000561120.1
ENST00000559236.1
ENST00000397702.2
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr8_-_18666360 0.10 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr14_-_104028595 0.10 ENST00000337322.4
ENST00000445922.2
BAG5
BCL2-associated athanogene 5
chr3_+_141105235 0.10 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr8_-_42698433 0.10 ENST00000345117.2
ENST00000254250.3
THAP1
THAP domain containing, apoptosis associated protein 1
chr9_+_84304628 0.10 ENST00000437181.1
RP11-154D17.1
RP11-154D17.1
chr15_+_45422131 0.10 ENST00000321429.4
DUOX1
dual oxidase 1
chr14_-_31889737 0.10 ENST00000382464.2
HEATR5A
HEAT repeat containing 5A
chr3_-_50340996 0.10 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
HYAL1
hyaluronoglucosaminidase 1
chr19_+_38880695 0.10 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chr18_+_32558380 0.09 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr9_-_88897426 0.09 ENST00000375991.4
ENST00000326094.4
ISCA1
iron-sulfur cluster assembly 1
chr22_-_29138386 0.09 ENST00000544772.1
CHEK2
checkpoint kinase 2
chr17_+_48046538 0.09 ENST00000240306.3
DLX4
distal-less homeobox 4
chr2_-_68479614 0.09 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr13_-_76111945 0.09 ENST00000355801.4
ENST00000406936.3
COMMD6
COMM domain containing 6
chr6_-_31745085 0.09 ENST00000375686.3
ENST00000447450.1
VWA7
von Willebrand factor A domain containing 7
chr3_-_98241598 0.09 ENST00000513287.1
ENST00000514537.1
ENST00000508071.1
ENST00000507944.1
CLDND1
claudin domain containing 1
chr1_-_103574024 0.09 ENST00000512756.1
ENST00000370096.3
ENST00000358392.2
ENST00000353414.4
COL11A1
collagen, type XI, alpha 1
chr12_-_25102252 0.09 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_-_197024965 0.09 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chr5_-_158636512 0.09 ENST00000424310.2
RNF145
ring finger protein 145
chr12_+_95612006 0.09 ENST00000551311.1
ENST00000546445.1
VEZT
vezatin, adherens junctions transmembrane protein
chr1_+_17634689 0.09 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr15_-_34629922 0.09 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr14_-_21492113 0.09 ENST00000554094.1
NDRG2
NDRG family member 2
chr17_-_15496722 0.09 ENST00000472534.1
CDRT1
CMT1A duplicated region transcript 1
chr1_-_109940550 0.08 ENST00000256637.6
SORT1
sortilin 1
chr5_+_170288856 0.08 ENST00000523189.1
RANBP17
RAN binding protein 17
chr3_-_126236588 0.08 ENST00000383579.3
UROC1
urocanate hydratase 1
chr11_-_10920714 0.08 ENST00000533941.1
CTD-2003C8.2
CTD-2003C8.2
chr3_-_195270162 0.08 ENST00000438848.1
ENST00000328432.3
PPP1R2
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr11_+_57310114 0.08 ENST00000527972.1
ENST00000399154.2
SMTNL1
smoothelin-like 1
chr12_+_120031264 0.08 ENST00000426426.1
TMEM233
transmembrane protein 233
chr7_-_151433393 0.08 ENST00000492843.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr10_-_33625154 0.08 ENST00000265371.4
NRP1
neuropilin 1
chr15_-_83315874 0.08 ENST00000569257.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr19_-_45826125 0.08 ENST00000221476.3
CKM
creatine kinase, muscle
chr12_-_96184533 0.08 ENST00000343702.4
ENST00000344911.4
NTN4
netrin 4
chr4_+_48343339 0.07 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr2_+_86426478 0.07 ENST00000254644.8
ENST00000605125.1
ENST00000337109.4
ENST00000409180.1
MRPL35
mitochondrial ribosomal protein L35
chr1_+_70876891 0.07 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr19_+_49467232 0.07 ENST00000599784.1
ENST00000594305.1
CTD-2639E6.9
CTD-2639E6.9
chr2_-_33824382 0.07 ENST00000238823.8
FAM98A
family with sequence similarity 98, member A
chr2_-_100106419 0.07 ENST00000393445.3
ENST00000258428.3
REV1
REV1, polymerase (DNA directed)
chr4_-_54457783 0.07 ENST00000263925.7
ENST00000512247.1
LNX1
ligand of numb-protein X 1, E3 ubiquitin protein ligase
chr1_-_155880672 0.07 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr11_+_111896090 0.07 ENST00000393051.1
DLAT
dihydrolipoamide S-acetyltransferase
chr3_+_12330560 0.07 ENST00000397026.2
PPARG
peroxisome proliferator-activated receptor gamma

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
0.1 0.4 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.4 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.1 0.3 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.1 0.5 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.5 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.1 1.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.5 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.3 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.1 GO:0038194 thyroid-stimulating hormone signaling pathway(GO:0038194)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793)
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.4 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.2 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.1 0.2 GO:0035508 positive regulation of myosin-light-chain-phosphatase activity(GO:0035508)
0.0 0.7 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.1 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.0 0.5 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 0.2 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.1 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.5 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.4 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.0 0.3 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.3 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.1 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786) kidney rudiment formation(GO:0072003)
0.0 0.1 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.0 0.1 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.0 0.1 GO:0060694 regulation of cholesterol transporter activity(GO:0060694) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.4 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.1 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.3 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.0 0.9 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.5 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.1 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.0 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.1 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.7 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.2 GO:0043291 RAVE complex(GO:0043291)
0.0 2.0 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0036117 hyaluranon cable(GO:0036117)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.1 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0035838 growing cell tip(GO:0035838)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.5 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 0.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.2 GO:0019961 interferon binding(GO:0019961)
0.0 0.1 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.0 0.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.0 0.5 GO:0000150 recombinase activity(GO:0000150)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo