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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TFCP2
Z-value: 1.44
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Transcription factors associated with TFCP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFCP2 | hg19_v2_chr12_-_51566562_51566584 | 0.91 | 1.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_62203808 Show fit | 1.78 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr7_-_120497178 Show fit | 1.67 |
ENST00000441017.1
ENST00000424710.1 ENST00000433758.1 |
tetraspanin 12 |
|
| chr2_-_61765315 Show fit | 1.49 |
ENST00000406957.1
ENST00000401558.2 |
exportin 1 (CRM1 homolog, yeast) |
|
| chr2_-_113542063 Show fit | 1.29 |
ENST00000263339.3
|
interleukin 1, alpha |
|
| chr19_-_19739321 Show fit | 1.24 |
ENST00000588461.1
|
lysophosphatidic acid receptor 2 |
|
| chr11_-_96123022 Show fit | 1.21 |
ENST00000542662.1
|
coiled-coil domain containing 82 |
|
| chr4_-_129207942 Show fit | 1.11 |
ENST00000503588.1
|
progesterone receptor membrane component 2 |
|
| chr11_+_65265141 Show fit | 1.01 |
ENST00000534336.1
|
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) |
|
| chrX_-_119693745 Show fit | 0.99 |
ENST00000371323.2
|
cullin 4B |
|
| chr9_+_125703282 Show fit | 0.97 |
ENST00000373647.4
ENST00000402311.1 |
RAB GTPase activating protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFCP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 1.9 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 1.4 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 0.2 | 1.3 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.1 | 1.3 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.0 | 1.2 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 1.0 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 1.0 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.2 | 0.9 | GO:0001835 | blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684) |
| 0.1 | 0.9 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 1.3 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 1.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.0 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 1.0 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.7 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 0.2 | 0.6 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.1 | 0.5 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 0.5 | GO:0032449 | CBM complex(GO:0032449) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 1.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 1.4 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 1.4 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 1.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 1.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.3 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 0.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.6 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 1.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.9 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.7 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 0.6 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |