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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TFAP4_MSC
Z-value: 1.12
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Transcription factors associated with TFAP4_MSC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP4 | hg19_v2_chr16_-_4323015_4323076 | -0.30 | 5.6e-01 | Click! |
| MSC | hg19_v2_chr8_-_72756667_72756736 | 0.30 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_68845417 Show fit | 1.39 |
ENST00000542875.1
|
RP11-81H14.2 |
|
| chr2_+_33701684 Show fit | 1.00 |
ENST00000442390.1
|
RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
|
| chr2_-_42160486 Show fit | 0.94 |
ENST00000427054.1
|
AC104654.2 |
|
| chr15_-_40401062 Show fit | 0.69 |
ENST00000354670.4
ENST00000559701.1 ENST00000557870.1 ENST00000558774.1 |
Bcl2 modifying factor |
|
| chr16_-_21289627 Show fit | 0.68 |
ENST00000396023.2
ENST00000415987.2 |
crystallin, mu |
|
| chr8_-_123706338 Show fit | 0.55 |
ENST00000521608.1
|
long intergenic non-protein coding RNA 1151 |
|
| chr14_-_91282821 Show fit | 0.47 |
ENST00000553948.1
|
tetratricopeptide repeat domain 7B |
|
| chr2_+_233404429 Show fit | 0.47 |
ENST00000389494.3
ENST00000389492.3 |
cholinergic receptor, nicotinic, gamma (muscle) |
|
| chr3_-_178790057 Show fit | 0.46 |
ENST00000311417.2
|
zinc finger, matrin-type 3 |
|
| chr3_-_178789220 Show fit | 0.45 |
ENST00000414084.1
|
zinc finger, matrin-type 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP4_MSC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.7 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.0 | 0.6 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.0 | 0.6 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 0.5 | GO:0006218 | uridine catabolic process(GO:0006218) |
| 0.1 | 0.4 | GO:1904761 | negative regulation of myofibroblast differentiation(GO:1904761) |
| 0.0 | 0.4 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.0 | 0.4 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.0 | 0.4 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 0.4 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.1 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.5 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 0.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.4 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.3 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 0.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.3 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 0.2 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.2 | 0.7 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.1 | 0.5 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.0 | 0.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 0.4 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.0 | 0.4 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.0 | 0.4 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.4 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.3 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 0.1 | 0.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.5 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 0.4 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.4 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.3 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.3 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 0.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.1 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |