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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFAP2E

Z-value: 0.40

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_360389710.493.2e-01Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_170459154 0.38 ENST00000473110.1
RP11-373E16.4
RP11-373E16.4
chr20_-_30539773 0.23 ENST00000202017.4
PDRG1
p53 and DNA-damage regulated 1
chr6_+_13272904 0.22 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr22_+_22676808 0.21 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr19_+_54960358 0.21 ENST00000439657.1
ENST00000376514.2
ENST00000376526.4
ENST00000436479.1
LENG8
leukocyte receptor cluster (LRC) member 8
chr19_-_39264072 0.21 ENST00000599035.1
ENST00000378626.4
LGALS7
lectin, galactoside-binding, soluble, 7
chr19_+_54960790 0.21 ENST00000443957.1
LENG8
leukocyte receptor cluster (LRC) member 8
chr19_+_3572758 0.19 ENST00000416526.1
HMG20B
high mobility group 20B
chr4_-_82393052 0.19 ENST00000335927.7
ENST00000504863.1
ENST00000264400.2
RASGEF1B
RasGEF domain family, member 1B
chr19_-_11039188 0.18 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr2_+_38893208 0.16 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr19_-_11039261 0.15 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr19_-_54676846 0.14 ENST00000301187.4
TMC4
transmembrane channel-like 4
chr19_+_11039391 0.14 ENST00000270502.6
C19orf52
chromosome 19 open reading frame 52
chr7_+_100464760 0.14 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr17_+_72428218 0.13 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_-_66056596 0.13 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_+_118478313 0.13 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr15_+_23810853 0.12 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr2_-_133429091 0.12 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr4_-_85419603 0.12 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr2_+_239335449 0.12 ENST00000264607.4
ASB1
ankyrin repeat and SOCS box containing 1
chr17_+_36584662 0.12 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr16_-_28506840 0.11 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr11_-_65625014 0.11 ENST00000534784.1
CFL1
cofilin 1 (non-muscle)
chr6_+_292253 0.11 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
DUSP22
dual specificity phosphatase 22
chr19_+_3572925 0.11 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
HMG20B
high mobility group 20B
chr19_+_38794797 0.11 ENST00000301246.5
ENST00000588605.1
C19orf33
chromosome 19 open reading frame 33
chr1_+_9005917 0.11 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chr6_-_88411911 0.10 ENST00000257787.5
AKIRIN2
akirin 2
chr11_-_66056478 0.10 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr17_-_39769005 0.10 ENST00000301653.4
ENST00000593067.1
KRT16
keratin 16
chr19_-_54676884 0.10 ENST00000376591.4
TMC4
transmembrane channel-like 4
chr22_+_31644388 0.10 ENST00000333611.4
ENST00000340552.4
LIMK2
LIM domain kinase 2
chr22_+_31608219 0.09 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIMK2
LIM domain kinase 2
chr19_-_46389359 0.08 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr3_+_32280159 0.08 ENST00000458535.2
ENST00000307526.3
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr17_+_40932610 0.08 ENST00000246914.5
WNK4
WNK lysine deficient protein kinase 4
chr3_+_4535025 0.08 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr16_-_72698834 0.08 ENST00000570152.1
ENST00000561611.2
ENST00000570035.1
AC004158.2
AC004158.2
chr11_-_6633799 0.07 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chrX_+_54466829 0.07 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr3_-_48632593 0.07 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr12_+_53773944 0.07 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr15_+_23810903 0.07 ENST00000564592.1
MKRN3
makorin ring finger protein 3
chrX_+_49028265 0.07 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr2_+_241375069 0.07 ENST00000264039.2
GPC1
glypican 1
chr7_-_129251459 0.07 ENST00000608694.1
RP11-448A19.1
RP11-448A19.1
chr1_+_901847 0.07 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr12_-_68797580 0.07 ENST00000539404.1
RP11-81H14.2
RP11-81H14.2
chr2_+_38893047 0.06 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr2_-_177502254 0.06 ENST00000339037.3
AC017048.3
long intergenic non-protein coding RNA 1116
chr11_+_63974135 0.06 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
FERMT3
fermitin family member 3
chr2_+_74741569 0.06 ENST00000233638.7
TLX2
T-cell leukemia homeobox 2
chr8_+_22250334 0.06 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr20_-_13619550 0.06 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
TASP1
taspase, threonine aspartase, 1
chr19_-_10613862 0.06 ENST00000592055.1
KEAP1
kelch-like ECH-associated protein 1
chr19_+_49458107 0.06 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX
BCL2-associated X protein
chr1_-_32801825 0.06 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr11_-_118305921 0.06 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr11_-_61062762 0.06 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr1_+_17248418 0.05 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr9_+_35605274 0.05 ENST00000336395.5
TESK1
testis-specific kinase 1
chr22_+_38146987 0.05 ENST00000418339.1
TRIOBP
TRIO and F-actin binding protein
chr14_-_25519095 0.05 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr12_-_75784669 0.05 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
CAPS2
calcyphosine 2
chr3_+_51428704 0.05 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr10_-_98273668 0.05 ENST00000357947.3
TLL2
tolloid-like 2
chr20_-_25371412 0.05 ENST00000339157.5
ENST00000376542.3
ABHD12
abhydrolase domain containing 12
chr11_-_65325430 0.05 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr19_+_36195429 0.05 ENST00000392197.2
ZBTB32
zinc finger and BTB domain containing 32
chr17_+_3627185 0.04 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr1_+_43148625 0.04 ENST00000436427.1
YBX1
Y box binding protein 1
chr10_-_50603497 0.04 ENST00000374139.2
DRGX
dorsal root ganglia homeobox
chr19_+_13229126 0.04 ENST00000292431.4
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chrX_+_51636629 0.04 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chrX_-_124097620 0.04 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr11_-_65624415 0.04 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr8_+_146277764 0.04 ENST00000331434.6
C8orf33
chromosome 8 open reading frame 33
chr3_+_49591881 0.04 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr7_-_100065686 0.04 ENST00000423266.1
ENST00000456330.1
TSC22D4
TSC22 domain family, member 4
chr19_+_45504688 0.04 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr1_-_11866034 0.03 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr17_+_48423453 0.03 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2
xylosyltransferase II
chr14_-_25519317 0.03 ENST00000323944.5
STXBP6
syntaxin binding protein 6 (amisyn)
chrX_-_118826784 0.03 ENST00000394616.4
SEPT6
septin 6
chr4_-_82393009 0.03 ENST00000436139.2
RASGEF1B
RasGEF domain family, member 1B
chr9_-_34662651 0.03 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr17_-_42188598 0.03 ENST00000591714.1
HDAC5
histone deacetylase 5
chr19_+_4969116 0.03 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chr22_-_39096661 0.03 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr3_-_48130314 0.03 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr15_+_77287426 0.03 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr3_+_171757346 0.03 ENST00000421757.1
ENST00000415807.2
ENST00000392699.1
FNDC3B
fibronectin type III domain containing 3B
chr1_-_11865351 0.03 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr12_-_48213735 0.02 ENST00000417902.1
ENST00000417107.1
HDAC7
histone deacetylase 7
chr12_-_48213568 0.02 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7
histone deacetylase 7
chr6_+_37787262 0.02 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr11_-_71752838 0.02 ENST00000537930.1
NUMA1
nuclear mitotic apparatus protein 1
chr4_-_101439242 0.02 ENST00000296420.4
EMCN
endomucin
chr20_+_55205825 0.02 ENST00000544508.1
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr1_+_104068312 0.02 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chrX_+_115567767 0.02 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr13_-_76056250 0.02 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr12_+_53443963 0.02 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_37551846 0.02 ENST00000443187.1
PRKD3
protein kinase D3
chr11_-_35440796 0.01 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_214163033 0.01 ENST00000607425.1
PROX1
prospero homeobox 1
chr12_-_65153175 0.01 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
GNS
glucosamine (N-acetyl)-6-sulfatase
chr19_+_13228917 0.01 ENST00000586171.1
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr22_+_31644309 0.01 ENST00000425203.1
LIMK2
LIM domain kinase 2
chr14_+_24837226 0.01 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr10_-_98480243 0.01 ENST00000339364.5
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr13_-_27334879 0.01 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chr3_+_50192833 0.01 ENST00000426511.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr1_+_150122034 0.01 ENST00000025469.6
ENST00000369124.4
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr12_+_57984965 0.01 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr4_+_154387480 0.01 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
KIAA0922
chr10_+_102505954 0.01 ENST00000556085.1
ENST00000427256.1
PAX2
paired box 2
chr6_+_42531798 0.00 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr2_+_232573208 0.00 ENST00000409115.3
PTMA
prothymosin, alpha
chr11_-_71752571 0.00 ENST00000544238.1
NUMA1
nuclear mitotic apparatus protein 1
chr11_+_66045634 0.00 ENST00000528852.1
ENST00000311445.6
CNIH2
cornichon family AMPA receptor auxiliary protein 2
chr6_+_7108210 0.00 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1
ras responsive element binding protein 1
chr6_+_7107830 0.00 ENST00000379933.3
RREB1
ras responsive element binding protein 1
chr11_-_47869865 0.00 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr2_+_232573222 0.00 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr11_+_64009072 0.00 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:0051511 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.0 0.0 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.1 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.0 GO:0032173 septin ring(GO:0005940) septin collar(GO:0032173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)