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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TEAD3_TEAD1
Z-value: 0.83
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Transcription factors associated with TEAD3_TEAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD1 | hg19_v2_chr11_+_12766583_12766592 | -0.52 | 2.9e-01 | Click! |
| TEAD3 | hg19_v2_chr6_-_35464727_35464738 | 0.10 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_38480100 Show fit | 0.75 |
ENST00000427592.1
|
solute carrier family 16 (monocarboxylate transporter), member 8 |
|
| chr10_-_90712520 Show fit | 0.70 |
ENST00000224784.6
|
actin, alpha 2, smooth muscle, aorta |
|
| chr2_-_25451065 Show fit | 0.57 |
ENST00000606328.1
|
RP11-458N5.1 |
|
| chr3_-_119379427 Show fit | 0.54 |
ENST00000264231.3
ENST00000468801.1 ENST00000538678.1 |
popeye domain containing 2 |
|
| chr19_+_34972543 Show fit | 0.53 |
ENST00000590071.2
|
Wilms tumor 1 interacting protein |
|
| chr11_+_48002279 Show fit | 0.48 |
ENST00000534219.1
ENST00000527952.1 |
protein tyrosine phosphatase, receptor type, J |
|
| chr8_+_144816303 Show fit | 0.45 |
ENST00000533004.1
|
FAM83H antisense RNA 1 (head to head) |
|
| chr12_-_122241812 Show fit | 0.42 |
ENST00000538335.1
|
AC084018.1 |
|
| chr17_+_37030127 Show fit | 0.42 |
ENST00000419929.1
|
LIM and SH3 protein 1 |
|
| chr3_-_191000172 Show fit | 0.41 |
ENST00000427544.2
|
urotensin 2B |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 1.0 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.2 | 0.9 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.1 | 0.8 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) |
| 0.0 | 0.6 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.1 | 0.5 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.0 | 0.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.5 | GO:0098743 | cell aggregation(GO:0098743) |
| 0.1 | 0.4 | GO:0035261 | external genitalia morphogenesis(GO:0035261) |
| 0.1 | 0.4 | GO:1903412 | response to bile acid(GO:1903412) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.6 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.0 | 0.5 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.4 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.0 | 0.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.3 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.0 | 0.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.3 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.6 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.5 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.5 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 0.4 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 0.0 | 0.4 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.0 | 0.4 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.0 | 0.4 | GO:0032450 | alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450) |
| 0.0 | 0.4 | GO:0016015 | morphogen activity(GO:0016015) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.3 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.6 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.5 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.4 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 0.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.2 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.1 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.1 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |