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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TCF7
Z-value: 0.41
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Transcription factors associated with TCF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7 | hg19_v2_chr5_+_133477905_133477956 | -0.47 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_69080590 Show fit | 0.28 |
ENST00000433116.2
ENST00000500695.2 |
RP11-637A17.2 |
|
| chr12_-_14924056 Show fit | 0.20 |
ENST00000539745.1
|
histone cluster 4, H4 |
|
| chr2_-_99871570 Show fit | 0.15 |
ENST00000333017.2
ENST00000409679.1 ENST00000423306.1 |
lysozyme G-like 2 |
|
| chr1_+_59762642 Show fit | 0.14 |
ENST00000371218.4
ENST00000303721.7 |
FGGY carbohydrate kinase domain containing |
|
| chr7_+_95115210 Show fit | 0.14 |
ENST00000428113.1
ENST00000325885.5 |
ankyrin repeat and SOCS box containing 4 |
|
| chr8_+_55471630 Show fit | 0.14 |
ENST00000522001.1
|
RP11-53M11.3 |
|
| chrX_-_148676974 Show fit | 0.13 |
ENST00000524178.1
|
heat shock transcription factor family, X linked 2 |
|
| chr19_-_44008863 Show fit | 0.12 |
ENST00000601646.1
|
pleckstrin homology-like domain, family B, member 3 |
|
| chr11_+_12302492 Show fit | 0.12 |
ENST00000533534.1
|
MICAL C-terminal like |
|
| chrX_+_148855726 Show fit | 0.12 |
ENST00000370416.4
|
heat shock transcription factor family, X linked 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0009253 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) |
| 0.0 | 0.1 | GO:0090381 | negative regulation of mesodermal cell fate specification(GO:0042662) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) |
| 0.0 | 0.1 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.0 | 0.1 | GO:0070666 | regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 0.0 | 0.1 | GO:0021912 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) |
| 0.0 | 0.1 | GO:0030573 | bile acid catabolic process(GO:0030573) |
| 0.0 | 0.1 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.0 | 0.1 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.1 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.1 | GO:2000329 | peptidyl-lysine oxidation(GO:0018057) negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | GO:0001534 | radial spoke(GO:0001534) |
| 0.0 | 0.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.1 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 0.0 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.1 | GO:0019150 | D-ribulokinase activity(GO:0019150) |
| 0.0 | 0.1 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.0 | 0.1 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.0 | 0.1 | GO:0016649 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.0 | 0.1 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.0 | 0.1 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 0.1 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 0.1 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.0 | 0.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |