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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TBX1
Z-value: 1.10
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Transcription factors associated with TBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX1 | hg19_v2_chr22_+_19744226_19744226 | 0.70 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 1.2 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.1 | 1.0 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 0.9 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 0.9 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.2 | 0.8 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 0.8 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.8 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.7 | GO:0009107 | lipoate biosynthetic process(GO:0009107) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 0.9 | GO:0072379 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 0.9 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 0.7 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 0.7 | GO:0070083 | clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.0 | 0.7 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.7 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.3 | 1.1 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.1 | 1.1 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 1.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 0.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 0.8 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.1 | 0.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.8 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 0.7 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 0.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.0 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 0.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 1.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.0 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.9 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.9 | REACTOME SIGNALING BY FGFR1 MUTANTS | Genes involved in Signaling by FGFR1 mutants |
| 0.0 | 0.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.8 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |