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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TBP
Z-value: 2.69
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Transcription factors associated with TBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg19_v2_chr6_+_170863353_170863390 | 0.72 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_615570 Show fit | 3.36 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
interferon regulatory factor 7 |
|
| chr10_+_91152303 Show fit | 3.30 |
ENST00000371804.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
|
| chr6_-_26189304 Show fit | 2.36 |
ENST00000340756.2
|
histone cluster 1, H4d |
|
| chr9_-_35658007 Show fit | 2.17 |
ENST00000602361.1
|
RNA component of mitochondrial RNA processing endoribonuclease |
|
| chr6_+_26104104 Show fit | 2.14 |
ENST00000377803.2
|
histone cluster 1, H4c |
|
| chr16_+_2014993 Show fit | 2.11 |
ENST00000564014.1
|
small nucleolar RNA host gene 9 (non-protein coding) |
|
| chr6_-_26043885 Show fit | 2.05 |
ENST00000357905.2
|
histone cluster 1, H2bb |
|
| chr10_+_91087651 Show fit | 1.68 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr12_-_121476959 Show fit | 1.61 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr6_+_26156551 Show fit | 1.60 |
ENST00000304218.3
|
histone cluster 1, H1e |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0031424 | keratinization(GO:0031424) |
| 1.1 | 3.4 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.8 | 3.3 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.0 | 3.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 3.1 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 2.9 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 2.6 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.0 | 2.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 1.7 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.3 | 1.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 3.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 3.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 2.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 2.4 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.2 | 2.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.7 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 3.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 3.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 2.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 2.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 2.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 1.7 | GO:0032564 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.0 | 1.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 3.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.2 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 8.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 3.2 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.2 | 3.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 2.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |