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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TAF1
Z-value: 2.12
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Transcription factors associated with TAF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg19_v2_chrX_+_70586140_70586218 | -0.30 | 5.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.3 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.1 | 4.1 | GO:1902100 | negative regulation of mitotic metaphase/anaphase transition(GO:0045841) mitotic spindle checkpoint(GO:0071174) negative regulation of metaphase/anaphase transition of cell cycle(GO:1902100) |
| 0.1 | 4.0 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.3 | 3.9 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.3 | 3.9 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 3.2 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 3.0 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 2.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 2.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 2.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.2 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 5.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 3.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.4 | 3.6 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.1 | 3.6 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 3.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.3 | 3.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 3.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.3 | 2.7 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.4 | 2.6 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 7.1 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 4.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 4.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 4.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.6 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 3.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 3.5 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 3.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 3.5 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 6.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 5.2 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 3.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 3.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 3.4 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 3.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 2.6 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 2.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.8 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 3.2 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 3.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.7 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 2.5 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 2.2 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 2.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |