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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for STAT5B
Z-value: 1.25
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Transcription factors associated with STAT5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5B | hg19_v2_chr17_-_40428359_40428462 | -0.72 | 1.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.1 | 1.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 0.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 0.7 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.1 | 0.7 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.1 | 0.7 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.0 | 0.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.2 | 0.6 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.1 | 0.6 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.1 | 0.6 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 1.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.7 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.6 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.5 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.4 | GO:0005879 | axonemal microtubule(GO:0005879) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 1.1 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.7 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.2 | 0.6 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.0 | 0.6 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.6 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 0.6 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.5 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 0.5 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.0 | 0.5 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 1.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.8 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.7 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 0.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.4 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 0.3 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |