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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for STAT1_STAT3_BCL6
Z-value: 0.97
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Transcription factors associated with STAT1_STAT3_BCL6
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115415.14 | signal transducer and activator of transcription 1 | |
| ENSG00000168610.10 | signal transducer and activator of transcription 3 | |
| ENSG00000113916.13 | BCL6 transcription repressor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL6 | hg19_v2_chr3_-_187455680_187455732 | -0.53 | 2.8e-01 | Click! |
| STAT3 | hg19_v2_chr17_-_40540586_40540600 | -0.33 | 5.2e-01 | Click! |
| STAT1 | hg19_v2_chr2_-_191878874_191878976 | 0.15 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_50649192 Show fit | 1.94 |
ENST00000443053.2
ENST00000348721.3 |
cytokine inducible SH2-containing protein |
|
| chr17_-_46692457 Show fit | 1.81 |
ENST00000468443.1
|
homeobox B8 |
|
| chr19_-_4717835 Show fit | 0.97 |
ENST00000599248.1
|
dipeptidyl-peptidase 9 |
|
| chr3_-_52864680 Show fit | 0.76 |
ENST00000406595.1
ENST00000485816.1 ENST00000434759.3 ENST00000346281.5 ENST00000266041.4 |
inter-alpha-trypsin inhibitor heavy chain family, member 4 |
|
| chr16_-_67517716 Show fit | 0.68 |
ENST00000290953.2
|
agouti related protein homolog (mouse) |
|
| chr6_+_26104104 Show fit | 0.67 |
ENST00000377803.2
|
histone cluster 1, H4c |
|
| chr2_+_9778872 Show fit | 0.65 |
ENST00000478468.1
|
RP11-521D12.1 |
|
| chr17_+_2264983 Show fit | 0.62 |
ENST00000574650.1
|
small G protein signaling modulator 2 |
|
| chr12_-_42878101 Show fit | 0.61 |
ENST00000552108.1
|
prickle homolog 1 (Drosophila) |
|
| chr3_-_145940214 Show fit | 0.56 |
ENST00000481701.1
|
phospholipid scramblase 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT1_STAT3_BCL6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 1.8 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 0.8 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.2 | 0.7 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
| 0.1 | 0.7 | GO:2000691 | regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.1 | 0.7 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.2 | 0.6 | GO:1990697 | protein depalmitoleylation(GO:1990697) |
| 0.2 | 0.6 | GO:0034499 | late endosome to Golgi transport(GO:0034499) |
| 0.0 | 0.6 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.1 | 0.5 | GO:0072255 | metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 0.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.3 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 0.2 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.1 | 0.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 1.0 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.7 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 0.6 | GO:1990699 | palmitoleyl hydrolase activity(GO:1990699) |
| 0.0 | 0.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.5 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 0.4 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 0.0 | 0.4 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 1.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.0 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 0.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.2 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.2 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.1 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |