ISMARA results: SREBF1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SREBF1_TFE3

Z-value: 1.68

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Transcription factors associated with SREBF1_TFE3

Gene Symbol	Gene ID	Gene Info
SREBF1 Ensembl NCBI GeneCards UniProt	ENSG00000072310.12	sterol regulatory element binding transcription factor 1
TFE3 Ensembl NCBI GeneCards UniProt	ENSG00000068323.12	transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SREBF1	hg19_v2_chr17_-_17740325_17740349	0.96	2.1e-03	Click!
TFE3	hg19_v2_chrX_-_48901012_48901050	0.86	2.6e-02	Click!

Activity profile of SREBF1_TFE3 motif

Sorted Z-values of SREBF1_TFE3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_58145889 Show fit	11.81	ENST00000547853.1	CDK4 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 4
chr20_-_44519839 Show fit	2.76	ENST00000372518.4	NEURL2 Ensembl NCBI GeneCards UniProt Show fit	neuralized E3 ubiquitin protein ligase 2
chr17_-_7137857 Show fit	2.67	ENST00000005340.5	DVL2 Ensembl NCBI GeneCards UniProt Show fit	dishevelled segment polarity protein 2
chr17_-_7137582 Show fit	2.41	ENST00000575756.1 ENST00000575458.1	DVL2 Ensembl NCBI GeneCards UniProt Show fit	dishevelled segment polarity protein 2
chr20_+_44519948 Show fit	1.94	ENST00000354880.5 ENST00000191018.5	CTSA Ensembl NCBI GeneCards UniProt Show fit	cathepsin A
chr16_+_2570340 Show fit	1.92	ENST00000568263.1 ENST00000293971.6 ENST00000302956.4 ENST00000413459.3 ENST00000566706.1 ENST00000569879.1	AMDHD2 Ensembl NCBI GeneCards UniProt Show fit	amidohydrolase domain containing 2
chr11_+_67159416 Show fit	1.77	ENST00000307980.2 ENST00000544620.1	RAD9A Ensembl NCBI GeneCards UniProt Show fit	RAD9 homolog A (S. pombe)
chr19_-_36545649 Show fit	1.72	ENST00000292894.1	THAP8 Ensembl NCBI GeneCards UniProt Show fit	THAP domain containing 8
chr16_+_28986134 Show fit	1.72	ENST00000352260.7	SPNS1 Ensembl NCBI GeneCards UniProt Show fit	spinster homolog 1 (Drosophila)
chr19_+_7587555 Show fit	1.64	ENST00000601003.1	MCOLN1 Ensembl NCBI GeneCards UniProt Show fit	mucolipin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF1_TFE3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	14.5	GO:1904637	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.5	5.8	GO:0000101	sulfur amino acid transport(GO:0000101)
1.3	5.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.2	4.3	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.4	3.9	GO:1904715	negative regulation of chaperone-mediated autophagy(GO:1904715)
0.1	3.8	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.9	3.6	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.6	3.3	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1	3.3	GO:0097352	autophagosome maturation(GO:0097352)
0.4	3.2	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)

Showing 1 to 10 of 388 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	21.4	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
2.4	14.5	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	11.0	GO:0043202	lysosomal lumen(GO:0043202)
0.1	5.4	GO:0016235	aggresome(GO:0016235)
0.5	3.5	GO:0098575	lumenal side of lysosomal membrane(GO:0098575)
0.3	3.2	GO:0032010	phagolysosome(GO:0032010)
0.1	2.4	GO:0042555	MCM complex(GO:0042555)
0.0	2.2	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.2	1.9	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2	1.9	GO:0030896	checkpoint clamp complex(GO:0030896)

Showing 1 to 10 of 134 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	13.8	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5	5.8	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1	4.8	GO:0005109	frizzled binding(GO:0005109)
0.2	4.2	GO:0015929	hexosaminidase activity(GO:0015929)
0.7	4.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	4.0	GO:0005507	copper ion binding(GO:0005507)
0.1	3.9	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.3	3.8	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	3.0	GO:0051082	unfolded protein binding(GO:0051082)
0.2	2.8	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)

Showing 1 to 10 of 259 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	14.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	4.9	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	3.7	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	3.3	PID ATR PATHWAY	ATR signaling pathway
0.0	2.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	2.0	PID LKB1 PATHWAY	LKB1 signaling events
0.0	2.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	1.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.6	PID NECTIN PATHWAY	Nectin adhesion pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	5.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	4.7	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.1	4.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	3.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	3.1	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	2.9	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1	2.6	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	2.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	2.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation

Showing 1 to 10 of 67 entries

Results for SREBF1_TFE3

Z-value: 1.68

Motif logo

Transcription factors associated with SREBF1_TFE3

Activity-expression correlation:

Activity profile of SREBF1_TFE3 motif

Sorted Z-values of SREBF1_TFE3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF1_TFE3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: