ISMARA results: SP3

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SP3

Z-value: 1.45

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Transcription factors associated with SP3

Gene Symbol	Gene ID	Gene Info
SP3 Ensembl NCBI GeneCards UniProt	ENSG00000172845.9	Sp3 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP3	hg19_v2_chr2_-_174828892_174828972	-0.53	2.8e-01	Click!

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_140115775 Show fit	1.59	ENST00000391553.1 ENST00000392827.1	RNF208 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 208
chr6_+_155316390 Show fit	1.42	ENST00000545347.1	TIAM2 Ensembl NCBI GeneCards UniProt Show fit	T-cell lymphoma invasion and metastasis 2
chr19_-_18717627 Show fit	1.18	ENST00000392386.3	CRLF1 Ensembl NCBI GeneCards UniProt Show fit	cytokine receptor-like factor 1
chr19_-_49522727 Show fit	1.16	ENST00000600007.1	CTB-60B18.10 Ensembl NCBI GeneCards UniProt Show fit	CTB-60B18.10
chr16_+_84002234 Show fit	1.15	ENST00000305202.4	NECAB2 Ensembl NCBI GeneCards UniProt Show fit	N-terminal EF-hand calcium binding protein 2
chr16_+_67700673 Show fit	1.12	ENST00000403458.4 ENST00000602365.1	C16orf86 Ensembl NCBI GeneCards UniProt Show fit	chromosome 16 open reading frame 86
chr16_+_77246337 Show fit	1.02	ENST00000563157.1	SYCE1L Ensembl NCBI GeneCards UniProt Show fit	synaptonemal complex central element protein 1-like
chr20_-_56884489 Show fit	1.00	ENST00000334187.8 ENST00000244070.3	PPP4R1L Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 4, regulatory subunit 1-like
chr2_-_45165994 Show fit	1.00	ENST00000444871.2	RP11-89K21.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-89K21.1
chr14_+_102027688 Show fit	0.95	ENST00000510508.4 ENST00000359323.3	DIO3 Ensembl NCBI GeneCards UniProt Show fit	deiodinase, iodothyronine, type III

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.0	2.2	GO:0018146	keratan sulfate biosynthetic process(GO:0018146)
0.0	2.1	GO:0046323	glucose import(GO:0046323)
0.1	1.9	GO:1904627	response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1	1.8	GO:0014848	urinary bladder smooth muscle contraction(GO:0014832) urinary tract smooth muscle contraction(GO:0014848)
0.1	1.8	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.1	1.7	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.1	1.6	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	1.6	GO:0032011	ARF protein signal transduction(GO:0032011)
0.1	1.5	GO:0035330	regulation of hippo signaling(GO:0035330)

Showing 1 to 10 of 1,190 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0042641	actomyosin(GO:0042641)
0.0	4.3	GO:0043202	lysosomal lumen(GO:0043202)
0.0	3.7	GO:0001726	ruffle(GO:0001726)
0.0	3.3	GO:0030426	growth cone(GO:0030426)
0.0	3.2	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	2.8	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	2.2	GO:0044453	nuclear membrane part(GO:0044453)
0.0	2.1	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	2.0	GO:0031228	intrinsic component of Golgi membrane(GO:0031228)
0.0	1.9	GO:0005776	autophagosome(GO:0005776)

Showing 1 to 10 of 332 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.6	GO:0005096	GTPase activator activity(GO:0005096)
0.0	5.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	2.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	2.6	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	2.2	GO:0003951	NAD+ kinase activity(GO:0003951)
0.0	2.1	GO:0005123	death receptor binding(GO:0005123)
0.0	1.9	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	1.8	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	1.7	GO:0017166	vinculin binding(GO:0017166)
0.0	1.7	GO:0070064	proline-rich region binding(GO:0070064)

Showing 1 to 10 of 668 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
4.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
2.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
2.6	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
2.6	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
2.4	NABA COLLAGENS	Genes encoding collagen proteins
2.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
2.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
2.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
2.2	PID TRAIL PATHWAY	TRAIL signaling pathway
1.9	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Showing 1 to 10 of 77 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	2.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	2.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	2.0	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	1.8	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	1.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	1.8	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	1.7	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	1.7	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	1.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation

Showing 1 to 10 of 112 entries

Results for SP3

Z-value: 1.45

Motif logo

Transcription factors associated with SP3

Activity-expression correlation:

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: