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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX30

Z-value: 0.74

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Transcription factors associated with SOX30

Gene Symbol Gene ID Gene Info
SOX30
ENSG00000039600.6 SRY-box transcription factor 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX30hg19_v2_chr5_-_157079428_157079452-0.805.9e-02Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_38821373 0.84 ENST00000394052.3
KRT222
keratin 222
chr3_-_122283424 0.70 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr12_-_66317967 0.46 ENST00000601398.1
AC090673.2
Uncharacterized protein
chr5_-_146461027 0.40 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr11_-_85430088 0.33 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr20_-_5426380 0.31 ENST00000609252.1
ENST00000422352.1
LINC00658
long intergenic non-protein coding RNA 658
chr12_+_11081828 0.30 ENST00000381847.3
ENST00000396400.3
PRH2
proline-rich protein HaeIII subfamily 2
chr3_-_165555200 0.28 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr11_-_85430204 0.28 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chr4_-_176733897 0.26 ENST00000393658.2
GPM6A
glycoprotein M6A
chr9_-_74383302 0.26 ENST00000377066.5
TMEM2
transmembrane protein 2
chr6_+_12290586 0.26 ENST00000379375.5
EDN1
endothelin 1
chr2_-_162931052 0.24 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr9_-_85882145 0.23 ENST00000328788.1
FRMD3
FERM domain containing 3
chr12_+_95611536 0.22 ENST00000549002.1
VEZT
vezatin, adherens junctions transmembrane protein
chr1_-_243418344 0.22 ENST00000366542.1
CEP170
centrosomal protein 170kDa
chr8_+_42195972 0.21 ENST00000532157.1
ENST00000265421.4
ENST00000520008.1
POLB
polymerase (DNA directed), beta
chr6_+_126240442 0.21 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr4_+_113152978 0.21 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr18_+_7946839 0.21 ENST00000578916.1
PTPRM
protein tyrosine phosphatase, receptor type, M
chr12_+_95611569 0.20 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
VEZT
vezatin, adherens junctions transmembrane protein
chr11_-_85430163 0.20 ENST00000529581.1
ENST00000533577.1
SYTL2
synaptotagmin-like 2
chr2_+_143635067 0.20 ENST00000264170.4
KYNU
kynureninase
chr1_-_243418650 0.19 ENST00000522995.1
CEP170
centrosomal protein 170kDa
chr19_-_17375541 0.19 ENST00000252597.3
USHBP1
Usher syndrome 1C binding protein 1
chr14_+_52456327 0.17 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr14_+_52456193 0.17 ENST00000261700.3
C14orf166
chromosome 14 open reading frame 166
chr11_-_8964580 0.17 ENST00000325884.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr4_+_54243798 0.17 ENST00000337488.6
ENST00000358575.5
ENST00000507922.1
FIP1L1
factor interacting with PAPOLA and CPSF1
chr13_-_41593425 0.17 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_95611516 0.17 ENST00000436874.1
VEZT
vezatin, adherens junctions transmembrane protein
chrX_+_102192200 0.17 ENST00000218249.5
RAB40AL
RAB40A, member RAS oncogene family-like
chr3_-_19988462 0.16 ENST00000344838.4
EFHB
EF-hand domain family, member B
chr11_-_102323489 0.16 ENST00000361236.3
TMEM123
transmembrane protein 123
chr11_+_46402744 0.16 ENST00000533952.1
MDK
midkine (neurite growth-promoting factor 2)
chr4_+_54243862 0.16 ENST00000306932.6
FIP1L1
factor interacting with PAPOLA and CPSF1
chr22_-_43485381 0.16 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
TTLL1
tubulin tyrosine ligase-like family, member 1
chr10_+_70480963 0.16 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
CCAR1
cell division cycle and apoptosis regulator 1
chr10_+_35416090 0.15 ENST00000354759.3
CREM
cAMP responsive element modulator
chr1_-_26231589 0.15 ENST00000374291.1
STMN1
stathmin 1
chr15_+_57211318 0.14 ENST00000557947.1
TCF12
transcription factor 12
chr1_-_243418621 0.14 ENST00000366544.1
ENST00000366543.1
CEP170
centrosomal protein 170kDa
chr10_+_35416223 0.13 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr1_+_185014496 0.13 ENST00000367510.3
RNF2
ring finger protein 2
chr5_+_170288856 0.13 ENST00000523189.1
RANBP17
RAN binding protein 17
chr4_+_54243917 0.12 ENST00000507166.1
FIP1L1
factor interacting with PAPOLA and CPSF1
chr10_+_35415851 0.12 ENST00000374726.3
CREM
cAMP responsive element modulator
chr2_+_99953816 0.11 ENST00000289371.6
EIF5B
eukaryotic translation initiation factor 5B
chr1_+_93913713 0.11 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr2_+_86669118 0.11 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr11_-_102323740 0.10 ENST00000398136.2
TMEM123
transmembrane protein 123
chr5_+_140729649 0.10 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr14_-_90421028 0.10 ENST00000267544.9
ENST00000316738.7
ENST00000538485.2
ENST00000556609.1
EFCAB11
EF-hand calcium binding domain 11
chr18_+_7946941 0.10 ENST00000444013.1
PTPRM
protein tyrosine phosphatase, receptor type, M
chr17_-_73149921 0.10 ENST00000481647.1
ENST00000470924.1
HN1
hematological and neurological expressed 1
chr9_+_103235365 0.10 ENST00000374879.4
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr22_+_46449674 0.09 ENST00000381051.2
FLJ27365
hsa-mir-4763
chr1_-_200379129 0.09 ENST00000367353.1
ZNF281
zinc finger protein 281
chr5_+_179135246 0.09 ENST00000508787.1
CANX
calnexin
chr17_+_67498295 0.08 ENST00000589295.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr6_-_134639180 0.08 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr17_+_47448102 0.08 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr1_-_26324534 0.08 ENST00000374284.1
ENST00000441420.1
ENST00000374282.3
PAFAH2
platelet-activating factor acetylhydrolase 2, 40kDa
chr12_-_49581152 0.08 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chrX_+_114874727 0.07 ENST00000543070.1
PLS3
plastin 3
chr1_-_198906528 0.07 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr11_-_85430356 0.07 ENST00000526999.1
SYTL2
synaptotagmin-like 2
chr12_-_99288536 0.07 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr17_+_67498538 0.06 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr22_+_31488433 0.06 ENST00000455608.1
SMTN
smoothelin
chrX_+_41192595 0.06 ENST00000399959.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr21_+_35553045 0.06 ENST00000416145.1
ENST00000430922.1
ENST00000419881.2
LINC00310
long intergenic non-protein coding RNA 310
chr2_-_37899323 0.06 ENST00000295324.3
ENST00000457889.1
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_+_77356248 0.06 ENST00000296043.6
SHROOM3
shroom family member 3
chr19_-_44439387 0.06 ENST00000269973.5
ZNF45
zinc finger protein 45
chr14_-_90420862 0.06 ENST00000556005.1
ENST00000555872.1
EFCAB11
EF-hand calcium binding domain 11
chr4_+_144303093 0.06 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr15_+_93426514 0.06 ENST00000556722.1
CHD2
chromodomain helicase DNA binding protein 2
chr12_-_10282742 0.06 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr10_-_62060232 0.06 ENST00000503925.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_-_204463829 0.05 ENST00000429009.1
ENST00000415899.1
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr7_-_44229022 0.05 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr21_+_30671690 0.05 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr6_+_22146851 0.05 ENST00000606197.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr16_+_87636474 0.05 ENST00000284262.2
JPH3
junctophilin 3
chr19_-_17375527 0.05 ENST00000431146.2
ENST00000594190.1
USHBP1
Usher syndrome 1C binding protein 1
chr1_+_40942887 0.05 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr6_-_161085291 0.04 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr12_+_50898881 0.04 ENST00000301180.5
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr8_-_141810634 0.04 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr21_+_30672433 0.04 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr5_-_134735568 0.04 ENST00000510038.1
ENST00000304332.4
H2AFY
H2A histone family, member Y
chr1_-_167883353 0.04 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr5_+_65222438 0.03 ENST00000380938.2
ERBB2IP
erbb2 interacting protein
chr5_+_38148582 0.03 ENST00000508853.1
CTD-2207A17.1
CTD-2207A17.1
chr22_-_30970560 0.03 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_-_119532127 0.03 ENST00000207157.3
TBX15
T-box 15
chr5_-_59481406 0.03 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_11422739 0.03 ENST00000279573.7
PRB3
proline-rich protein BstNI subfamily 3
chr1_-_21503337 0.03 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr10_+_35415978 0.02 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr15_+_69857515 0.02 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr2_+_232573222 0.02 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chrX_+_70503433 0.02 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr1_+_47489240 0.02 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr1_-_156828810 0.01 ENST00000368195.3
INSRR
insulin receptor-related receptor
chr20_-_45981138 0.01 ENST00000446994.2
ZMYND8
zinc finger, MYND-type containing 8
chr1_+_185703513 0.01 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr2_+_27719697 0.01 ENST00000264717.2
ENST00000424318.2
GCKR
glucokinase (hexokinase 4) regulator
chr2_+_232573208 0.01 ENST00000409115.3
PTMA
prothymosin, alpha
chr5_+_135468516 0.01 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD5
SMAD family member 5
chr3_+_19988566 0.01 ENST00000273047.4
RAB5A
RAB5A, member RAS oncogene family
chr12_+_11905413 0.01 ENST00000545027.1
ETV6
ets variant 6
chr12_-_11422630 0.01 ENST00000381842.3
ENST00000538488.1
PRB3
proline-rich protein BstNI subfamily 3
chr6_-_11779174 0.01 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr21_+_35552978 0.01 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr1_+_240255166 0.01 ENST00000319653.9
FMN2
formin 2
chr5_-_141338627 0.00 ENST00000231484.3
PCDH12
protocadherin 12
chr8_+_24151553 0.00 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr11_+_128563948 0.00 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr4_+_187148556 0.00 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
KLKB1
kallikrein B, plasma (Fletcher factor) 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.3 GO:0070101 nitric oxide transport(GO:0030185) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.1 0.2 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.1 0.2 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.1 0.2 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.9 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.2 GO:0030421 defecation(GO:0030421)
0.0 0.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0046292 spermatid nucleus elongation(GO:0007290) formaldehyde metabolic process(GO:0046292)
0.0 0.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0033265 choline binding(GO:0033265)
0.1 0.2 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.7 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway