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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX21

Z-value: 0.70

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.039.6e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_101361107 0.66 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)
chr19_+_42381337 0.47 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr10_-_18944123 0.36 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr3_-_37034702 0.31 ENST00000322716.5
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr9_-_70465758 0.29 ENST00000489273.1
CBWD5
COBW domain containing 5
chr4_-_39034542 0.28 ENST00000344606.6
TMEM156
transmembrane protein 156
chr14_+_64565442 0.26 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr12_-_10588539 0.24 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
KLRC2
NKG2-E
killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chr3_+_38537960 0.24 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr13_-_45048386 0.21 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chr3_-_45957088 0.21 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr8_-_94029882 0.21 ENST00000520686.1
TRIQK
triple QxxK/R motif containing
chrY_+_14813160 0.20 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr5_+_67588312 0.18 ENST00000519025.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_86849883 0.18 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr8_+_74271144 0.17 ENST00000519134.1
ENST00000518355.1
RP11-434I12.3
RP11-434I12.3
chr7_+_7196565 0.16 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr3_-_45957534 0.16 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr3_-_155524049 0.15 ENST00000534941.1
ENST00000340171.2
C3orf33
chromosome 3 open reading frame 33
chr18_+_29769978 0.15 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr14_+_20215587 0.15 ENST00000331723.1
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3
chr6_-_121655593 0.15 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chr4_-_103747011 0.14 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_-_17243579 0.14 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr5_-_95158644 0.14 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr10_-_71169031 0.14 ENST00000373307.1
TACR2
tachykinin receptor 2
chr1_+_158901329 0.13 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr14_+_85994943 0.13 ENST00000553678.1
RP11-497E19.2
Uncharacterized protein
chr1_-_169455169 0.13 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr15_+_58702742 0.12 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr4_-_103746924 0.12 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr3_+_38537763 0.12 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr1_-_54303934 0.12 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr12_+_123011776 0.12 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr2_-_106013207 0.11 ENST00000447958.1
FHL2
four and a half LIM domains 2
chr4_-_103746683 0.11 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_-_12084770 0.11 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr3_-_164875850 0.11 ENST00000472120.1
RP11-747D18.1
RP11-747D18.1
chr1_+_199996733 0.11 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr11_+_114549108 0.10 ENST00000389586.4
ENST00000375475.5
NXPE2
neurexophilin and PC-esterase domain family, member 2
chr10_+_5005445 0.10 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr6_+_42531798 0.10 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr17_+_66245341 0.09 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr6_+_131894284 0.08 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr3_-_155572164 0.08 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr7_+_6713376 0.08 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
AC073343.1
Uncharacterized protein
chr11_-_8285405 0.08 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr1_+_221051699 0.07 ENST00000366903.6
HLX
H2.0-like homeobox
chr5_-_95158375 0.07 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr16_-_15149828 0.07 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr1_-_151148492 0.07 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr10_-_61495760 0.07 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr7_-_37382683 0.06 ENST00000455879.1
ELMO1
engulfment and cell motility 1
chrX_-_153210107 0.06 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP
renin binding protein
chr1_+_152881014 0.06 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr14_-_92588013 0.06 ENST00000553514.1
ENST00000605997.1
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr9_+_109685630 0.06 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr5_+_140579162 0.06 ENST00000536699.1
ENST00000354757.3
PCDHB11
protocadherin beta 11
chr18_-_47018897 0.05 ENST00000418495.1
RPL17
ribosomal protein L17
chr16_-_15982440 0.05 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr12_+_101673872 0.05 ENST00000261637.4
UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr8_-_50466973 0.04 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr6_-_154567984 0.04 ENST00000517438.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr8_+_26150628 0.04 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr17_+_60457914 0.04 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr22_+_39353527 0.04 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr14_+_92588281 0.04 ENST00000298875.4
ENST00000553427.1
CPSF2
cleavage and polyadenylation specific factor 2, 100kDa
chr14_-_92588246 0.04 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr12_+_69742121 0.04 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr14_+_50291993 0.03 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr3_-_141747439 0.03 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chrY_+_16634483 0.03 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr5_+_134181755 0.03 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
C5orf24
chromosome 5 open reading frame 24
chr18_-_47018769 0.03 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr6_+_31371337 0.02 ENST00000449934.2
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr12_+_59194154 0.02 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr20_+_56964253 0.02 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr18_+_43319467 0.02 ENST00000591541.1
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr6_-_112575912 0.02 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr3_-_186288097 0.02 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr2_+_3705785 0.01 ENST00000252505.3
ALLC
allantoicase
chr18_-_47018869 0.01 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr1_+_203764742 0.01 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A
zinc finger CCCH-type containing 11A
chr19_+_18682531 0.01 ENST00000596304.1
ENST00000430157.2
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr1_+_67632083 0.01 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr5_-_179045199 0.01 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr9_-_104249400 0.00 ENST00000374848.3
TMEM246
transmembrane protein 246
chr8_+_67687413 0.00 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr7_-_107968921 0.00 ENST00000442580.1
NRCAM
neuronal cell adhesion molecule
chr21_+_30672433 0.00 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr8_-_66750978 0.00 ENST00000523253.1
PDE7A
phosphodiesterase 7A

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.1 GO:0030474 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 0.1 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.0 0.3 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.3 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.0 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.1 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)